Abstract:Using 4-cyano-3-methoxybenzaldehyde and tert-butyl acetoacetate as raw materials, finerenone racemes were obtained through condensation, cyclization, oxyalkylation, hydrolysis and ammonolysis, which broke through the difficulty of hydrolysis of conventional esters. A series of optimization of reaction conditions were carried out, and the finerenone racemes were obtained with a total yield of 33.5%. The results showed that the reaction conditions were mild and the yield was high, which provided a reasonable route for the synthesis of finerenone raw materials. The structure of the product was determined by 1 HNMR, 13CNMR and HRMS.