In order to improve the defects of the ultrafiltration membrane prepared by blending UiO66 particles with polyether sulfone (PES), such as poor anti-fouling ability and weak interaction between particles and membrane, a novel ultrafiltration membrane was obtained by phase inversion of PES polymer dopes containing modified UiO66 particles. The modified UiO66 particles (UiO66-NH2 and PVP-UiO66-NH2) was obtained by solvothermal method through introducing amino groups and polypyrrolidone (PVP) onto UiO66 by replacing ligands. The effects of types and contents of particles on pure water flux, retention rate, anti-fouling ability, long-term stability, hydrophilicity and mechanical properties of PES blending ultrafiltration membranes were investigated. The results show that the water flux of the blending membrane with 2.5 wt% PVP-UiO66-NH2 reaches to 506.9 L/(m2·h), which is doubled compared to the original membrane. The tensile strength is about 3.06 MPa, and the flux recovery rate is 95.97% after simple water washing after BSA contamination. The water flux can be maintained at about 300 L/(m2·h) for long-term filtration. The novel ultrafiltration membrane not only has enhanced pure water flux, but also has excellent anti-fouling ability and stability, suggesting a high application prospect.