Based on the dry and wet integrated dissociation technique, the low-grade iron-containing attpulgite (APT) from Baiyin, Gansu was treated to produce modified and refined attapulgite (SAPT). Subsequently, an in-situ reduced attapulgite (HAPT) catalytic material was prepared using hydrogen as the reductant through a high-temperature in-situ reduction method. The degradation performance of sulfadiazine (SDZ), one kind of antibiotics, under the persulfate (PDS) system using HAPT was investigated. In this work, we carefully investigated the effects of various parameters, including HAPT dosage, PDS concentration, initial SDZ concentration, initial pH, and temperature, on the degradation of SDZ. The results demonstrated that at a HAPT dosage was 2 g/L, a PDS concentration was 3.6 mmol/L, an initial SDZ concentration of 10 mg/L, an initial pH was 3, and a temperature of 30 ℃, the degradation rate of SDZ in the HAPT/PDS system reached 99.97% within 4 hours. Further analysis using electron paramagnetic resonance (EPR) and free radical quenching experiments reveal that the main active species in the HAPT/PDS system were sulfate radicals (SO4?-) and hydroxyl radicals (?OH), with SO4?- playing a dominant role. Furthermore, the addition of hydroxylamine effectively accelerated the remove of sulfadiazine. This work presents a novel method for treating antibiotic wastewater using low-grade attapulgite as a raw material, thus achieving the high-value utilization of attapulgite resources.