The Ag/SiO2 catalyst was prepared using the equal volume impregnation method and its catalytic performance with varying Ag loads (percentage of Ag mass based on SiO2 mass) was investigated through XRD, SEM, TEM, O2-TPD characterization, and MOP catalytic oxidation reaction test. A comparison between the microscopic morphology and catalytic properties of 15% Cu/SiO2 and 15% Ag/SiO2 revealed that the latter had higher activity. At a reaction temperature of 300 ℃, liquid space velocity of 1.8 mL/(g·h), and volume air flow rate of 80 mL/min, the conversion rate for MOP reached 95.05%, while selectivity for methoxyacetone was at 85.07%. Stable operation for up to 72 hours was achieved; however, after an extended run time of up to 80 hours, carbon deposition rates reached as high as13.5%. Compared to Cu species particle size in the former (15.2 nm), Ag species particle size in the latter (3.1 nm) is smaller with better dispersion due to oxygen adsorption type interaction between Ag and SiO2 carrier which are important factors for oxidation reactions on this catalyst system along with good carbon resistance providing favorable conditions for stability.