Copper nanoparticle@fullerenol complex was synthesized through the hydroxylation of fullerene using C60 and CuCl2·2H2O as precursors by photochemical reduction method. The composition, morphology and particle size distribution of fullerenol and complex were characterized by FTIR, TGA, TEM, XPS and dynamic light scattering (DLS). 2,2-biphenyl-1-picrohydrazyl (DPPH) free radical scavenging and zebrafish damage repair model experiment were used to investigate the antioxidant and biological repair properties of the complex. The results show that the chemical formula of fullerenol is C60(OH)24·11H2O, while copper nanoparticles with an average particle size of 8.6 nm were successfully coated on the surface of fullerenol, forming a complex with an average particle size of about 534 nm. the composite with a mass concentration of 0.1 mg/mL could scavenge nearly 100% DPPH radicals, and half maximal inhibitory concentration (IC50) was 0.0145 mg/mL. and the composite with 6.25×10-3% concentration had the best anti-inflammatory repair effect of 55%.