Encapsulation of astaxanthin in liposomes using supercritical carbon dioxide
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R D Institute of Fluid and Powder Engineering,Dalian University of Technology

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TQ469

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    Abstract:

    Astaxanthin liposomes were prepared using supercritical carbon dioxide with soya lecithin as the lipid carrier. The effectiveness of the supercritical method for the preparation of astaxanthin liposomes was confirmed through the use of TEM, XRD and FTIR characterisation. The effects of preparation pressure and temperature on the particle size distribution and zeta potential of astaxanthin liposomes were investigated based on nanoparticle size analyser measurements. The encapsulation rate of astaxanthin was determined using a UV spectrophotometer, and the slow-release effect and bioavailability of astaxanthin liposomes were tested by in vitro simulated release and simulated digestion experiments. The results demonstrated that, under optimal conditions, the average particle size of astaxanthin liposomes prepared with a supercritical carbon dioxide pressure of 20 MPa and a temperature of 50 ℃ was 236 nm, with an astaxanthin encapsulation rate of 97.18%. Following a 30-day storage period, the astaxanthin retention rate of astaxanthin liposomes at 4 and 25 ℃ was 94.13% and 89.04%, respectively. In vitro release experiments demonstrated that astaxanthin liposomes exhibited The astaxanthin slow-release effect was observed to be more pronounced, with total release rates of 69.3% and 91% at 4 and 12 h, respectively. Furthermore, in vitro digestion simulations demonstrated that astaxanthin liposomes exhibited enhanced digestion and absorption in the intestine.

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History
  • Received:March 12,2024
  • Revised:April 24,2024
  • Adopted:April 07,2024
  • Online: April 14,2025
  • Published:
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