A series of multiple dynamic bond synergies base self-healing polyurethanes (SPPU) were synthesized via reaction of terephthalaldoxime, which was prepared from hydroxylamine hydrochloride and terephthalaldehyde, with polytetrahydrofuranediol, isophorone diisocyanate and bis(4-hydroxyphenyl) disulfide. Characterization of the synthesized benzaldehyde dioxime and SPPU was conducted using 1H NMR and FTIR, confirming the synthesis of self-healing polyurethane containing oxime and aromatic disulfide bonds. Evaluation of SPPU self-healing capability was performed through scratch and healing tests. Quantum chemistry calculations were employed to determine the bond energies of the two types of hydrogen bonds in the polyurethane, and a discussion on the principles of self-healing ensued. The findings revealed that in a series of polyurethane elastomers, SPPU-3 exhibited the optimal comprehensive performance, with oxime and disulfide bonds each comprising half of the chain extender. After 2 hours of healing at room temperature, scratches nearly vanished, and after 48 hours of healing at the same temperature, the polyurethane achieved a self-healing rate of 93.78%.