Abstract:Hyperbranched polymer (amine-ester) with terminal alcohol group (HPAE) was synthesized by polycondensation of N,N-diethyol-3-amine-methylpropionate(prepared by Miachael addition reaction of methyl acrylate with diethanolamine) as an A2B-type monomer with trimethylol propane as the core moiety, proceeding in one-step procedure in the melt with p-toluenesulfonic acid as catalyst. Then, it was modified by ferrocenecarboxylic acid to obtain ferrocene-containing hyperbranched poly (amine-ester). The reaction conditions were obtained: reaction time 4h at temperature 140℃,catalyst dosage 2.5% based on the mass of reaction materials, molar feed ratio n(OH):n(ferrocenecarboxylic acid)=1:0.8. The obtained polymer was characterized by means of IR, 1HNMR, it shows that the ferrocene was successfully grafted to the HPAE, and the grafting rate reached 70%.

Abstract:A new synthetic protocol for access to the antivascular and antitumor natural product combretastatin B-1(CB1) has been developed. Starting from isovanillin(1), 2-bromo-3-hydroxy-4-methoxybenzaldehyde (2) could be readily obtained via bromination with DBDMH. Perkin condensation between 2 and 3, 4, 5-trimethoxyphenylacetic acid (3) gave Z/E-2-(3, 4, 5-trimethoxyphenyl)-3-(2-bromo-3-acetoxy-4-methoxyl) acrylic acid (Z-4, E-4), which underwent hydroxylation and the tandem decarboxylation-isomerization reactions to afford E-combretastatin A-1 (E-CA1). Finally, CB1 could be obtained by catalytic hydrogenation.

Abstract:2-[4-(4-Fluorobenzyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine was synthesized from pyrazolo[1,5-a]pyridine-2-carbaldehyde and 1-piperazinearboxaldehyde through reductive amination, amide hydrosis and N-alkylation. The structures of the intermediates and the target compound were confirmed by 1H NMR, 19F NMR and ESI- MS. Through in vitro receptor binding assay, the affinity constants of the target compound were determined to be 1.2, 3900 and 1890 nM for D4, D2, D3 receptor, respectively. It indicated that 2-[4-(4-fluorobenzyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine is a potential dopamine D4 receptor ligand.

Abstract:Unsymmetrical pyridinyl-imine complexes of cobalt (CoLn2, n = 1, 2... 6) containing functionalities attached to the alkyl or aromatic group bonded to the imino nitrogen were synthesized and evaluated as potential catalysts for epoxidation of styrene, and their related compounds were characterized by elemental analysis, 1H NMR, FT-IR, TG, et al. The influences of reaction conditions were further researched, including complexes, solvent, reaction tempreture, reaction time. The results showed that the complexes of cobalt(II) containing trimethylsiloxy attached to aromatic group bonded to the imino nitrogen (CoL42) was the most effective catalyst for epoxidation of styrene. These further explained that electron donating groups bonded to the imino nitrogen and the good steric effect of complexes increased the activity of the catalysts. Under optimal reaction conditions, the highest conversion of styrene was 99.9% with 62.4% styrene oxide selectivity.

Abstract:Low infrared emissivity coatings were prepared by leafing Al powder, ZnS, adhesive, dispersant, and thickener. The coatings were applied to Al plate to investigate the emittance of coatings containing different adhesives. The coatings were applied to fabrics, and microstructure and influence of preparation conditions on the infrared emittance of coating were analyzed. Oily polyurethane presented lower emittance than other adhesives. The emittance of coating on fabric reduced gradually with the increase of Al powder and ZnS. When oily polyurethane was used as adhesive contenting 35%-40% Al, 2% ZnS, polyester coating gave the radiant emissivity of 0.69.

Abstract:A-norandrostane-3-oxo-16β-carboxylate was synthesized from 3-oxo-4-androstene-17β-carboxylate by Beayer-Villger oxidation and two independent chemical operation,which were sodium methoxide promoted ring contraction rearrangement and decarbonylation, the total yield was 39.2 %.By controlling the amount of oxidant metachloroperbenzoic acid (m-CPBA) and using ZnCl2 as Lewis acid,the yield of the product of Beayer-Villger oxidation 3-oxo-4-androstene-17β-carboxylate was 92.3 %. 3-oxo-4-androstene-17β-carboxylate was converted to A ring constracted β-oxo aldehyde in the effect of sodium methoxide in dry tetrahydrofunan,,then it was decarbonylated by NaOH aqueous solution ,the product A-norandrostane-3-oxo-16β-carboxylate was prepared，its yield was 42.5 %.The method offers a new and unique synthetic route for preparation of A-norsteroidal compound.

Abstract:Solid acid Ga2(SO4)3/attapulgite catalyst was prepared by loading Ga2(SO4)3 on attapulgite. The structure of catalyst was characterized by means of IR and XRD. The preparation conditions on catalyst, catalytic activity and stability of catalyst were investigated by synthesis of hexyl butyrate. The kinetics characters of catalytic reaction were discussed as well. The optimum preparation conditions on catalyst were as follow: sulfuric acid as impregnation liquid was 1.1 mol/L, the loading of Ga2(SO4)3 was 25% in catalyst, calcinated at 350 ℃ for 2.5 h. Under the optimum esterificaton conditions, the average yield was 98.1 %. the yield was no less than 85 % after used for 5 times. The results of reaction kinetics showed that it was the second order reaction, and the apparent activation energy was 76.17 kJ/mol.

Abstract:The copper(II) complex of α-pyridine formic acid was synthesized by room temperature solid-state reaction using α-pyridine formic acid and cupric acetate as reactants. The composition and structure of the complex was characterized by EDTA titration, elemental analysis, infrared spectrum, X-ray powder diffraction, thermogravimetric and differential thermal analysis. The chemical formula of the complex was Cu(C5H4NCOO)2?2H2O. The results of indexes to the X-ray powder diffraction data indicate that the crystal structure of the complex belongs to monoclinic system. The lattice parameters are: a = 1.3821 nm, b = 1.2308 nm, c = 0.7272 nm, β = 93.68? The results of characterization showed that the copper(II) was six-coordinated by the heterocyclic nitrogen atoms and hydroxy oxygen atoms in carboxyl of the two ligands, oxygen atoms from two water molecules, respectively.

Abstract:A new type of heterocyclic compound was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The new ligand was then coordinated to Gd3 , Mn2 and Fe3 , respectively. The paramagnetic metal complexes were gained. The structures of heterocyclic compound, new DTPA ligand and metal complexes were characterized by FTIR, elemental analysis and 1HNMR. The longitudinal relaxivity (r1) was also measured. The results showed that the r1 of the Gd3 complex (13.20 mmol?L-1?s-1) and Mn2 complex (12.11 mmol?L-1?s-1) were both higher than that of MRI contrast agent Gd-DTPA (3.62 mmol?L-1?s-1) used in clinic. In addition, the thermodynamical parameters of the interaction between the metal complexes and bovine serum albumin (BSA) were conducted by isothermal titration calorimetry (ITC). The Ka of Gd complexes, Mn complexes and Fe complexes were determined to be 1.17?06, 2.91?05 and 4.04?04, respectively.

Abstract:The glycosidic precursor of Trollius Chinensis Bunge was hydrolyzed by enzymatic hydrolysis, then the hydrolytic components were analyzed by GC/MS and 25 aromatic components were identified, such as Dehydro linalool, Linalool, and so on, most of them exsit in essential oil of tobacco generally. It is certified that enzymatic hydrolysis has a great value in keeping glycosidic aromatic components. The suitable glycosidic precursor of different concentration was added to cigarette and tasted, the results showed that it has potential application in cigarette because of it could enhance aroma quality, increase the quantity of aroma, reduce irritancy and offensive odor.

Abstract:α-Amino dodecanoic acid (ADA) was synthesized by the amination of α-chloro dodecanoic acid (CDA) derived from chlorination of natural dodecanoic acid, and the molecular structure of ADA was identified by FT-IR、ESI-MS and 1H-NMR. Effects of reaction temperatures, reaction times, dosages of catalyst and ratio of raw materials on the yield of ADA was investigated, unfortunately, the yield of ADA was lower in normal temperature technology which was accounted as the competition of the side hydrolysis reaction. A temperature programming of normal temperature followed by hydrothermal was applied to inhibit hydrolysis effectively, which evolved the amination a practical organic synthesis reaction. The yield of ADA was significantly improved from about 80% under the normal temperature technology to 91% under the optimal temperature programming technology when the amination was run with n(ammonia) :n(CDA) = 20 :1 at 70 ℃ for 12 h following 100 ℃ for 4 h.

Abstract:The preparation of cis- and trans-2-hexyl-4-acetoxytetrahydrofuran has been studied. 1-Decen-4-ol was obtained in 86% yield by the Grignard reaction starting from allyl chloride and heptanal, which was then epoxidized by m-chloroperoxybenzoic acid to give 1,2-epoxy-4-decanol in 89% yield. The cis- and trans-2-hexyl-4-hydroxytetrahydrofuran mixture was produced in 90% yield through an intramolecular nucleophilic substitution of 1,2-epoxy-4-decanol promoted by K2CO3. The ratio of trans- and cis-isomer was 53/47. 2-Hexyl-4-hydroxytetrahydrofuran reacted with p-nitrobenzoyl chloride and the products of esterification were separated by column chromatography to give trans- and cis-isomer individually in 52% and 40% yield respectively. The trans- or cis-ester was hydrolyzed in a basic solution to give trans- or cis-2-hexyl-4-hydroxytetrahydrofuran in 85% or 82% yield. trans- or cis-2-Hexyl-4-acetoxytetrahydrofuran was produced after acetylation with Ac2O in 83% or 85% yield. The odor and flavor dilution factor of trans- or cis-2-hexyl-4-acetoxytetrahydrofuran were evaluated by GC-O, which indicated that two isomers differed in odor feature and odor intensity.

Abstract:Four matrine derivatives were synthesized by Claisen-Schimidt condensation in which matrine reacted with anisaldehyde or veratrum aldehyde or 3,4,5-trimethoxy-benzaldehyd or 2,3,4-trimethoxy-benzaldehyd in sodium hydride solution. The most suitable condition for the synthesis was decided by the orthogonal experiment. Inhibitory effects of these compounds were determined by the MTT assay on the growth of HT-29 cells and PANC-1 cells. These compounds exhibited better inhibitory effects than matrine . Four matrine derivatives being synthesized have better anticancer activity than matrine.

Abstract:Two dicyanostilbene-derived two-photon fluorescence (TPF) dyes with a D-π-A architecture were synthesized as the model compounds to systematically study the effect of the dicyano and the terminal substituent on the two-photon absorption (TPA). These two compounds (DMO and DMA) exhibit very large two-photon absorption cross sections (δ). DMA with the terminal dimethylamino group has longer emission wavelength (λem(DMA) = 554 nm > λem(DMO) = 459 nm), larger δ (δ(DMA) = 3650 GM > δ(DMO) = 830 GM) and higher fluorescence quantum yield (η(DMA) = 0.456 > η(DMO) = 0.294) than with the terminal methoxy group. The ideal terminal substituent should not be the alkoxy group but the substitutedamino group. This class of dicyanostilbene dyes possess small molecule size, large δ (830–3650 GM), long-wavelength emission (459−554 nm) and large Stokes shift (131−150 nm), and are ideal chromophores for TPF labels and probes.

Abstract:Poly(amine-ester)-1,8-naphthalimide dendrimer (PAE-1,8-NL) is synthesized from ethylenediamine (EDA), trimethylolpropane triacrylate (TMPTA) and 1,8-naphthalic anhydride, the yield is 32.79%. The structure of PAE-1,8-NL is charactracterized by IR and 1HNMR. The physical performance of PAE-1,8-NL with the lanthanide ions (La3 、Nd3 、Dy3 、Gd3 、Eu3 ）and hydrogen ion is studied by UV spectra and fluorescent spectra. The results show that PAE-1,8-NL in chloroform-ethanol (V:V=1:1) diluent solution excited at 357 nm appears two fluorescence peaks（370nm and 386nm）, assigning to naphthyl monomer emission and intramolecular naphthyl-naphthyl dimmer/exmier emission. The presence of the lanthanide ions and hydrogen ions is found to have a very small effect on the naphthyl monomer emission peak but it has a disciplinarian effect on the intensity of the naphthyl-naphthyl dimmer/exmier emission peak. The enhancement in the fluorescence mainly owes to photoinduced electron transfer effect. Fluorescence of PAE-1,8-NL is first increased then decreased by the lanthanide ions; increased by hydrogen ion; first increased then decreased by the lanthanide ions and hydrogen ion in the solution.

Abstract:The compound 4-(4-chlorophenyl)-2,6-diphenylpyridine was synthesized by one-pot in potassium hydroxide and aqueous ammonia solution from 4-chlorobenzaldehyde and acetophenone. The title compound was characterized by 1H NMR, 13C NMR and FTIR(Fourier Transform Infrared Spectroscopy). The pH titration indicated that the title compound was strong sensitive to pH in absorption spectra and fluorescence spectra. The absorption intensities at 256 nm decreased upon pH variation from 4.70 to 4.22. At the mean time, both the absorption intensities at 312 nm and the emission intensities at 403 nm gradually increased. The thermal property of the title compound was also measured and high thermal stability was demonstrated.

Abstract:molecularly imprinted polymers(MIP) for Dibutyl phthalate(DBP) was synthesized on the surface of silica gel with DBP as template molecule, acrylic acid as functional monomer and vinyltrimethoxysilane as grafting agent. The intermolecular interaction between acrylic acid and DBP was confirmed by ultraviolet spectroscopy(UV) , the surface morphology of the MIP was characterized by scanning electron microscope (SEM) and the structure of polymers was analyzed by fourier transform infrared spectroscopy (FTIR). The binding properties of the MIP were evaluated by equilibrium adsorption experiment method. The scatchard plot suggested that the template-polymer system had two site of adsorption behavior with the dissociation constant(Kd) of 0.0284 mmol L-1, 0.675 mmol L-1 and the max adsorption capacity(Qmax) of 4.035 祄ol g-1, 30.507 祄ol g-1 for the higher affinity site and lower affinity site, respectively. In addition, the selectivity factor of DBP towards dimethyl phthalate(DMP) and bis(methoxyethyl) phthalate (DMOP) was 2.04 and 1.57, respectively. Indicating good recogntion characteristic to DBP.

Abstract:Au/Fe3O4 nanocomposites were prepared by anchoring gold nanoparticles onto Fe3O4 support surfaces. First, spherical gold nanoparticles was synthesised via a reducing method with hydroquinone as reductants. Then, Fe3O4 supports were synthesized by a solvothermal method and modified by mercaptopropionic acid (MPA). At last, gold nanoparticles were immobilized on the surface of Fe3O4 support using MPA as a linker,. The morphology, crystallinity, magnetism and catalytic activity of the Au/Fe3O4 nanocomposites were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, vibrating sample magnetometry (VSM) and UV–Vis spectrophotometer (UV-vis). The results indicate that the surface of the Au/Fe3O4 composite is coated with gold nanoparticles (NPs), the nanocomposites are monodisperse and supermagnetic, and show an excelently catalytic activity in the reduction of 4-nitrophenol to 4-aminophenol with sodium borohydride.

Abstract:To solve the problem of nanoparticles’ aggregation,the nano Ag/liquid crystals hybrid composite were prepared via in-situ synthesis method by thermo-decomposing Ag2C2O4 in thermotropic liquid crystals.The obtained composite of nano Ag/liquid crystals were characterized with X-ray diffraction (XRD),transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy(XPS).The results showed that the particle sizes of Ag were less than 20nm,which were mono-dispersed in liquid crystal, and no aggregation was observed.

Abstract:Abstract: New difunctional photoinitiator was synthesized with 1,1,3-trimethyl- 3 -phenyLindane through friedel-crafts and hydroxylation reactions, the performance of the product is more excellent than traditional small molecule photoinitiators. 1H NMR and IR were applied to characterize the product. Compared with small molecule photoinitiators, the UV absorbtion of the new compound shifted 14nm and migration rates in the cured film lowered 80~90%, and therefore kept a good thermal stability. At the same time, it retains polymerization rate as high as small molecule photoinitiators，so it is an excellent photoinitiator.

Abstract:N-benzoyl-O-benzoyl-L-tyrosine(Ⅰ) were synthesized，in the yields of 87 %，by L-tyrosine with benzoyl chloride under the alkaline condition. Ⅱ is formed with L-Phenylglycinol condensation under the IBCF-NMM, Ⅲ was synthesized by alkaline hydrolysis of Ⅱ. 2-Dimethylaminoethyl chloride hydrochloride by n(anhydrous K2CO3)︰n(compound 3)=7︰1 gave Ⅳ with a yield of 79 % at 110 ℃ for 4 h. 11 compounds of derivatives were synthesized by compound Ⅳ in DMF, reacted with an organic acid under conditions of EDC•HCl, and 4-dimethylamino pyridine. Its structure was confirmed by NMR, ESI-MS.

Abstract:A key intermediate 3-Fluoro-4-morpholin-4-yl-phenylamine (4) can be synthesized by substitution, reduction and diazotization - halogenating reaction with morpholine and 3,4-difluoronitrobenzene. Also, intermediate (R)–5- (N-methyl phthalimide-yl)-2-oxazolidinone(6)can be synthesized with (R)-epichlorohydrin, potassium cyanate, phthalimide potassium.Linezolid was prepared through condensation, hydrolysis with (4) and (6). The target product was characterized by means of 1HNMR．The influencing factors in the synthetic reaction of compound 2、4、6、7 and 1 were investigated． The optimized overall yield was 26%．

Abstract:Eight fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole were synthesized in the yields of 79 ~ 87% by SNAr reaction of 5-aryl-2-mercapto-1,3,4-thiadiazoles with 4-chloro-1-phenyl-6-trifluoromethyl-1H-pyrazolo[3,4-d]pyrimidine, which were efficiently prepared from 5-amino-4-cyano-1-phenyl-1H-pyrazole, trifluoroacetic acid and trichlorophosphate by one-pot procedure in 61% yield. The structures of the products were confirmed by IR, 1H NMR, MS and elemental analysis. The primary antibacterial activity of these compounds against two bacteria (Staphylococcus aureus and Escherichia coli) was screened. The results indicated that the title compounds exhibit antibacterial activity against Staphylococcus aureus, and compounds IVb and IVh have relatively good bacteriostatic effect.

Abstract:In this paper, we choose the compound foaming agent system with better stability using a synergistic effect of the mixed system of anion and cation surfactant, and characteristics of formation of vesicles that foam stability increased. It is found that when the carbon chain length is less than 16, The longer the carbon chain, the better stability of foam. We have obtained the systems by means of orthogonal experimental design, the optimal mixture ratio of the system is SDS(Sodium Lauryl SulfateSodium Dodecyl Sulfate):AOS(Sodium Alpha-olefin Sulfonate):AES(Sodium Alcohol Ether Sulphate):CTAB(Hexadecyl trimethyl ammonium Bromide)=1:2:2:2,whose the half-life is nearly 4 times than SDS’s, and the polyoxyethylene chain makes the foam stability increase. At the same time, it is also found that The maximum value of the foam viscosity is 112mPa•s in a certain concentration of Na+, and The maximum value of the half-time is 50min. But it is easy to precipitate in the condition of Ca2+, and the foam performance will be worse. Through experimental evaluation, the mixed system showed the better salt-resistance, liquid carrying capacity and compatibility with methanol.

Abstract:An efficient and rapid procedure for ring opening of various epoxides with aromatic amines under water phase in the presence of Ionic liquid [Bmim]Im to synthesis β-amino alcohol, and the yield reached more than 84%. The effects of catalyst and its dose, ingredient ratio, reaction temperature and the recycling of [Bmim]Im were investigated. The optimum conditions were n(aromatic amines) : n(epoxides) = 1:1.2 and at 60℃. What’s more, [Bmim]Im reused five times , the yield could also reach more than 79%.

Abstract:Sodium α-hydroxyl dodecanoate (SHD) was simply synthesized directly from α-chlorine dodecanoic acid (CDA) through hydrothermal alkaline hydrolysis, and structure of α-hydroxyl dodecanoic acid (HDA), the acidified product of SHD, was identified by FT-IR and 1H NMR. The influence of reaction temperatures, reaction times and alkaline concentrations on the yield of SHD was investigated. The experimental results indicated that the yield of SHD was 98.7 % when alkaline hydrolysis was run under hydrothermal conditions in w(NaOH)=10 % aqueous NaOH solution and n(NaOH) : n(CDA) = 2.1 : 1 at 160 ℃ for 6 h. Some surfactant properties of SHD such as Kraft point (KP), hard ion resistance, requirement of lime soap dispersant, foaming ability, surface tension and cmc were determined and compared with sodium dodecanoate (SD). It was showed that the KP of SHD was 35 ℃ and 8 ℃ lower than that of parent SD, which means SHD had better cold water solubility. The hard ion resistance of SHD was somewhat higher than that of SD and the requirement of lime soap dispersant of SHD decreased to one half of the SD which showed that SHD displayed better solubility in hard water than that of SD. Therefore, SHD showed the potential to act as the new soap-base material applied in cold water or hard water.