Abstract:Multi-carboxyl P(POSS-MAA) composite material was prepared by the free radical polymerization of methacrylic acid (MAA) and Octavinyloctasilsesquioxane (POSS-Vi) which was obtained by vinyl trimethoxysilane(A-171) of hydrolysis and condensation. The structure of the polymer was characterized by Nuclear Magnetic Resonance(NMR), Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Transmission Electron Microscope(TEM), the results showed that P(POSS-MAA) composite was successfully obtained, and the POSS-Vi in P(POSS-MAA) composite can be uniformly dispersed. It was indicated that the shrinkage temperature and thickening rate of the leather had improved, in addition, the chromium content in the waste solution was also decrease when the P(POSS-MAA) composite combined with mass fraction 2% chromium was applied to the tanning process of goat acid skin. Meanwhile, when the content of the POSS-Vi was 6% in the P(POSS-MAA) composite, the shrinkage temperature ( Ts ) can reach up to 96.5℃ and thickening rate can also increased to 36% after the leather pretanned with the P(POSS-MAA) composite combined with 2% chromium , and the chromium mass concentration in the waste solution can be decreased from 122mg/L to 41mg/L compared with chrome tanning.

Abstract:2,8-dibromo-11H-pyrido[2,1-b]quinazolin-11-one was synthesized from 5-bromoisatin, 2,5-dibromopyridine. Then three new quinazolinone derivatives with yields between 68% and 85% were synthesized via suzuki coupling, structures of the compounds were identified by nuclear magnetic resonance spectroscopy and mass spectroscopy．Their optical physical properties were investigated by UV-Vis and fluorescence spectroscopy．Their electrochemical properties were studied by cyclic voltammetry and theoretical calculation methods. The results showed that the introduction of donor groups on the planar structure of parent ring extend the π-conjugation system, reduced the π-π intermolecular stacking of parent ring compound, and the formation of push-pull structure by connecting donor groups to quinazolinone backbone decreased energy gap of entire molecule. These quinazolinone derivatives are a kind of potential third-order nonlinear optical materials．

Abstract:Abstract: The 1,6-hexanediamine and isophoronediamine reacted with ethylene carbonate to produce carbamate diols, which reacted with dimethyl malonate by transesterification to form malonate terminated carbamates. The Michael addition reaction of malonate terminated carbamates with 1,6-hexanediol diacrylate,1,3-neopentyl glycol diacrylate, and polyethylene glycol diacrylate forming multifunctional acrylates containing carbamate groups (NIPUs). The structure of the synthesized intermediates and NIPUs was characterized by 1HNMR and high resolution mass spectrometry. The photo curing kinetics of NIPUs was studied by FTIR. The UV cured film properties of synthesized multifunctional acrylates gel were preliminary evaluated. The results showed that the multifunctional acrylate solution with 3% (total mass fraction) of photoinitiator 1173 and 10 % (total mass fraction) of HDDA could be cured in 60 s forming film with smooth surface and good flexibility (0.5 ~2.0 mm). The gel rate of film was reached above 96%.The adhesion of cured film to the glass was 0~2 level. The pencil hardness of UV cured film based carbamate acrylates derived from HDDA and NPGDA is up to 6 H.

Abstract:A new method for preparation of -amino acids was designed and realized by using a hydrogenation reaction as the key strategy. Ten benzyl -azidocinnamates were prepared from the ethyl 2-azidoacetate and aromatic aldehydes through the following combined processes of condensation of aldehyde and ester, saponification of methyl -azidocinnamates and esterification of the -azidocinnamic acids with benzyl alcohol. Then the hydrogenation of the benzyl -azidocinnamates was investigated, and the optimized conditions employed Pd/C (10% Pd) at 30% weight of the substrate as the catalyst, methanol as the solvent, and the pressure of hydrogen gas at 3 Mpa. The three-site conversion is featured with the combination of the reduction of azido group, the hydrogenation of C=C bond and the hydrogenolysis of benzyl ester, efficiently affording the corresponding -amino acids in 76~89% yields. Further, the substituents of chlorine and bromine on the aromatic ring of substrates were also removed during the hydrogenation reaction. The NMR analysis of the reaction mixture indicated that the conversion proceeded through the complicated hydrogenation process, while the ultimate product was clearly delivered. The pure -amino acids were obtained through a very simple filtration to remove the Pd/C catalyst.

Abstract:Hydrophobic emulsion was synthesized by copolymerization of butyl acrylate and vinyl silicone resin. α-Fe2O3 nanoparticles were prepared by precipitation method, and then modified by the silane coupling agent. Superhydrophobic cotton fabric was prepared by dip-coating of cotton fabric with hydrophobic emulsion and α-Fe2O3 dispersion. The structure and morphology of α-Fe2O3 and superhydrophobic cotton fabric were characterized by XRD, FTIR and SEM. The influence of the dip-coating times of emulsion and α-Fe2O3 dispersing on the hydrophobicity of cotton fabric was investigated. And the influence of UV irradiation on the wettability of superhydrophobic cotton fabric was studied. Moreover, oil-water separation performance of the superhydrophobic cotton fabric was determined. The results showed that the cotton fabric obtained superhydrophobicity after 2 times dip-coating of hydrophobic emulsion and α-Fe2O3 dispersion respectively, and its contact angle was 158.6?. After UV irradiation, the front side of the fabric turned to be superhydrophilic, while the reverse side was still superhydrophobic, the resulting cotton fabric showed unidirectional moisture conductivity. The separation efficiency of superhydrophobic cotton fabric to oil and water in oil-water mixture was 96.1% and 99.0%, respectively.

Abstract:CuO/CeO2 catalysts were prepared by impregnation method after the morphology of CeO2 nanomaterials first synthesized by hydrothermal method was changed by simply changing the roasting atmosphere, and the application of CuO/CeO2 catalysts to methanol steam reforming reaction was studied. The catalytic materials were characterized by SEM, XRD, BET, H2-TPR, N2O titration and XPS, and the effect of CeO2 morphology on the structure, property and performance of the catalysts was investigated. The results indicated that CuO/CeO2 catalysts, which were obtained from the CuO loaded by the nano-rods CeO2, demonstrated the best catalytic performance, because of the strong reaction between the nano-rods CeO2 and CuO, plenty of lattice defect and oxygen vacancy on the surface, therefore, the resulted increase of the surface Cu content of the CuO/CeO2 catalyst, the decrease of the reduction temperature of the Cu special, and hence the better catalytic activity. Over it, the methanol conversion was 100% and the CO concentration was 0.16% under 260 °C and with a water/methanol molar ratio of 1.2 and methanol gas hourly space velocity of 800 h-1.

Abstract:Reaction conditions for the NiMo/Al2O3-catalyzed production of bio-paraffins through an integrated process combining hydrodeoxygenation (HDO) of fatty acid methyl esters (FAMEs) derived from waste cooking oils and the subsequent hydrodenitrogenation (HDN) have been optimized in the following work. Under the optimal HDO conditions containing a temperature of 380 ℃, a hydrogen pressure of 2 MPa, a H2/FAMEs volume ratio of 1000, and a space velocity of 1 h-1, the presulfided NiMo/Al2O3 catalysts converted FAMEs to bio-paraffins with an overall selectivity of normal alkanes above 97%. The employed catalysts showed enough structural stability and high resistance to coke in the HDO of FAMEs, with an identical structure to the fresh catalysts observed and an amount of deposited carbonaceous species at 3.18% measured after reaction for 1000 h. However, the deoxygenated products appeared to be colored, especially after an exposure to sunlight, due to the undecomposed residual fragments of chlorophyll. The following HDN reaction over NiMo/Al2O3 catalysts reduced significantly their fluorescence and removed more than 90% nitrogen-containing impurities in the bio-paraffins under conditions of a temperature of 310 ℃, a hydrogen pressure of 2 MPa, a H2/paraffin volume ratio of 2000, and a space velocity of 0.25 h-1.

Abstract:In this study, we successfully fabricated dense and thin 13X molecular sieve membranes without any cracks, pinholes or other defects on porous α-Al2O3 tube by combination of 3-aminopropyl triethoxy silane (APTES) surface modification, vacuum pre-coating sol technology and hydrothermal crystallization method. The effects of APTES concentration and hydrothermal crystallization number on 13X molecular sieve layers were studied emphatically. The results demonstrated that the best 13X molecular sieve membranes with a thickness of about 10～15 μm could be obtained with 46 mg/ml of APTES surface treatment and 2 times of hydrothermal crystallization. The purification results indicated that the above 13X molecular sieve membranes could deeply purify the trace amount of dimethyl ether, methanol and propanal impurities to below 1?10-6 mol/mol from gaseous olefins at the initial concentration of 20?10-6 mol/mol under room temperature, exhibiting much more excellent purification performance than that of granular 13X molecular sieve adsorbents. In particular, the breakthrough times of 13X molecular sieve membranes for dimethyl ether, methanol and propanal were 16 h, 44.7 h, 94 h in N2 system, and 25.2 h, 102 h, 178 h in C2H4 system.

Abstract:The dye molecule Rhodamine-B was used to hydrophobically modify the core-shell Fe3O4@SiO2 nanoparticles, and the modified nanoparticles were used as stabilizer to prepare Pickering emulsions. The modified Fe3O4@SiO2 nanoparticles and Pickering emulsions were characterized and investigated by Zeta potential, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle measurement, optical microscope and conductivity measurement. The results showed that the mono-disperse nanoparticles with particle diameter 150 nm were synthesized successfully. Rhodamine-B was successfully modified to the surface of Fe3O4@SiO2 nanoparticles and the contact angle increases from 30? to 120?. And the concentration of emulsifier particles has great effects on the stability of the emulsions. Moreover, the stability of emulsions can be modulated by applying a magnetic field.

Abstract:A series of conversion-absorption ZnO based desulfurizers were prepared by using industrial ZnO and ZnO obtained by basic zinc carbonate decomposition as active component respectively, γ-Al2O3 as structure additive and K2CO3 as basic additive. The effects of ZnO precursors and γ-Al2O3 precursors on the desulfuration properties of prepared ZnO based desulfurizers were investigated at 300℃and atmospheric pressure with a gas space velocity of 2000 h-1. The results showed that the pore structure and basicity of ZnO based desulfurizers could significantly affect their desulfurization properties. The desulfurizer using ZnO obtained by basic zinc carbonate decomposition as the active component had high removal efficiency and good breakthrough sulfur capacity, and the breakthrough sulfur capacity was increases about 10 times comparing with that of the desulfurizer using industrial ZnO as the active component. In addition, the γ-Al2O3 prepared by different precursors had influences on the desulfurization properties of the prepared ZnO based desulfurizers. The γ-Al2O3 decomposed from pseudo boehmite obviously improved desulfurization properties of the desulfurizers, the breakthrough sulfur capacity was 12.18%. Among these desulfurizers, the desulfurizer using ZnO decomposed from basic zinc carbonate as the active component, γ-Al2O3 decomposed from pseudo boehmite as the structure additive and K2CO3 as the alkaline additive, could convert and absorb COS with a COS conversion of 99.98% and a breakthrough sulfur capacity of 4.03%.

Abstract:The polybutylene succinate (PBS) was hydrophobically modified by various content of L-glutamic acid (Glu) and blended with phosphate starch (PPS) by emulsion-casting method to prepare PBS -co-Glu/PPS composite. The chemical structure of PBS-co-Glu copolyester was characterized by FTIR and 1H-NMR. The hydrophilicity, crystallinity and mechanical properties of PBS-co-Glu copolyester were analyzed by GPC, XRD, POM, SEM and tensile test, Lipase degradation experiment was performed to evaluate the degradability of composite materials. The results showed that the elongation at break of PBS-co-Glu/PPS composite increased with the increase of Glu content, and the value elongation at break reached the maximum when the Glu content was 4%, at the same time, transmittance and degradability were significantly increased.

Abstract:Surface modified SiO2 nanoparticles, SCL@SiO2 were prepared by adsorbing sodium conjugated linoleate (SCL) on the surface of SiO2 nanoparticles, in which SCL molecules were stabilized through self-crosslinking by thermal polymerization at 80 oC and the surface wettability of SiO2 nanoparticles was improved. Zeta potential results showed that SCL was adsorbed and solidified on the surface of SiO2 nanoparticles by this way. Liquid paraffin/water type Pickering emulsion was stabilized by the SCL@SiO2 nanoparticles alone and more stable than conventional emulsion. Moreover, the adsorbed and polymerized SCL layer on the SCL@SiO2 nanoparticles was more stable than the simply SCL-adsorbed SiO2 nanoparticles, which causes sizes of both the SCL@SiO2 nanoparticles and the resulted Pickering emulsion droplets were pH-responsive.

Abstract:The polyester polyol was prepared by depolymerizing polyethylene terephthalate(PET) using catalyst with single step depolymerization technology in ordinary pressure,rigid polyurethane foam was prepared by using the polyester polyol with physical foaming method,to achieve the purpose of recycling of used PET.The hydroxyl,acid and viscosity of the polyester polyol as the response value.Dosages of catalyst and alkali，pyrolysis time were chosen as principal factors,and the optimized conditions for alcoholysis of PET were obtained with using response surface methodology(RSM) were as follows:catalyst Sb2O3 0.3% of PET weight,alcoholysis agents diglycol(DEG) 100% of PET weight,reaction time 2.5 hours.The experimental verification indicated that the conditions by RSM analysis were reliable,the hydroxyl value,acid value and viscosity of the product were 503.9 mgKOH/g,2.4 mgKOH/g and 1310 mPa·s,respectively.Rigid polyurethane foam is made with the polyester polyol,its coefficient of thermal conductivity is 0.02～0.03 W/(m·K) and density is 40～50 kg/m3,it shows that the recycling of used PET can be achieved through this method,and its recycling value was improved.

Abstract:Picolinamides with one, two and three alkoxy chain(s), named V1, V2, and V3, were synthesized and their gelation properties, together with the ion response of their organogels were tested. The microstructure and gelation force of the gels from the three compounds were checked by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultra-violet-visible spectroscopy (UV) and 1H nuclear magnetic resonance (1H NMR). Though the number of alkoxy chain of the three picolinamides is different, the morphologies of the checked organogels from them are all fibrous and they have clear ribbonlike 3D networks. What is more, they all have lamellar structure. It is found that hydrogen bonding, π-π interaction, and van der Waals interaction are the driving force of gelation. The organogels from V1, V2, and V3 can respond to the stimuli of both F-and Cu2+. Their reversible gel-sol transitions can be induced by heating and cooling, adding and removing F-, reducing Cu2+ and oxidizing Cu+, coordinating Cu2+ and releasing Cu2+, respectively. The organogels are efficient multiple responding ones.

Abstract:The microcapsules loaded with quercetin were prepared by supercritical fluid extraction of emulsions (SFEE). The influence of process parameters like operating temperature and pressure, CO2 flow rate and emulsion parameters was studied with respect to microcapsules size, distribution and solvent residue. The solvent residue and microcapsules were characterized by headspace gas chromatography, field emission scanning electron microscopy, Zeta potential and Fourier transform infrared spectroscopy. The results showed that the solvent residue can be as low as 59 mg/L after 40 min treatment at 313 K, 9 MPa and CO2 flow rate of 0.4 L/min. When the wall material concentration increases from 25 g/L to 100 g/L, the microcapsules size increased from 0.9 m to 3.7 m. Compared with the solvent evaporation method, the SFEE method can effectively remove the organic solvent in a short time and the analyses confirmed that the prepared microcapsule has high sphericity, clear interface and good stability in water.

Abstract:A series of thermoplastic polyurethane with isophorone diisocyanate (IPDI), Poly-terephthalic acid-3-methyl-1,5-amyl glycol ester diol (TPA-1000), polyethylene glycol (PEG-2000) and diethylene glycol (DEG) were synthesized . The 20wt% lithium salt was added to prepare all-solid-polymer electrolyte (SPE). The results showed that with the decrease of TPA-1000 and the increase of PEG-2000 , the heat resistance of SPE increasing, the glass transition temperature decreasing, the tensile strength decreasing and the elongation at break increasing. The relationship between ionic conductivity and temperature was accorded with the Arrhenius equation. The electrochemical windows of SPE except for the pure PEG-2000 were all above 4.0V at 80 ℃. When TPA-1000 and PEG-2000 had a mass ratio of one to two (SPE4), the comprehensive properties of electrolyte was the best. The mechanical strength was 1.87 Mpa, the conductivity was 2.15?10-4 S cm-1 and the electrochemical window was 4.3V. The discharge of all-solid-state battery assembled with SPE4 can reach 150 mAh/g at 0.2 C under 80 ?C.

Abstract:Three kinds of organic mediators based on arylimidazole (M), triphenylamine (P) and carbazole (C) were synthesized and their electrochemical redox reversibility were characterized through CV. Their redox potentials and electrochemical reversibility were greatly effected by the organic framework of the mediator. The electro-oxidation activity of p-MT under P and C, respectively, were studied through CV and controlled potential electrolysis at room temperature. When 10% H2O was added，the yield of p-MBA was 83% on the electro-oxidation of p-MT under 1mmol/L P at 1.2V. And the excellent electro-catalytic activity and selectivity on the electro-oxidation of p-MBzOH to p-MBA were showed. Compared the activity of P and C on the selectively electro-oxidation synthesis of p-MBA，P with lower redox potential was suit for p-MT with lower oxidation potential, while C with higher redox potential was suit for p-MBzOH with higher oxidation potential.

Abstract:Using potato starch as the basic skeleton, small molecule acrylic acid (AA), structurally elastic straight pullulan (PULL) as raw material in the environment of potassium persulfate as initiator, N,N'-methylenebisacrylamide as cross-linking agent, the starch-acrylate-pullulan semi-interpenetrating network polymer (st-AA-PULL) was prepared by two-step aqueous solution microwave method.FTIR, SEM, and BET were used to analyze the molecular structure characteristics, and the hydration characteristics of the product were investigated. The results of hydration characteristics showed that the swelling rate of distilled water by st-AA-PULL was as high as 1333 g/g, and the swelling rate of tap water and physiological saline were 536 g/g and 126 g/g, respectively;the semi-interpenetrating network material has better water retention compared with traditional polymeric materials ,it retains nearly 30% of moisture after standing at 60℃ for 90 min. The water absorption rate can still reach nearly 60% after repeating the water absorption five times; and the NaCl salt tolerance is also greatly improved in the concentration range of 0.02 to 0.10 mol/L，the equilibrium swelling ratio was maintained at 130 g/g at salt concentration of 0.10 mol/L.

Abstract:A new method of using ethanol-K2HPO4 aqueous two-phase system for extracting spiramycin was established. The optimum equation suitable for bimodal data fitting of the system was selected. The influence of K2HPO4 mass fraction, ethanol mass fraction, spiramycin concentration, extraction temperature and pH on the partition coefficient and extraction efficiency was investigated. The experimental results showed that the extraction process of spiramycin was spontaneous, endothermic and entropy increasing. Under the condition of K2HPO4 mass fraction of 20%, ethanol mass fraction of 16%, extraction temperature of 25℃, and pH of 9.2~9.5, the partition coefficient and extraction efficiency of spiramycin were above 36.66 and 97.11%, respectively. When pH = 9.5, the partition coefficient reached 47.52 and the extraction efficiency reached 97.97%. The purification factor and extraction efficiency of spiramycin using ethanol-K2HPO4 aqueous two-phase extraction were high. The phase-forming materials ethanol and K2HPO4 can be recycled for reuse, avoiding secondary pollution. A new method was provided for the treatment of isovalerylspiramycin production wastewater containing spiramycin.

Abstract:Abstract: Zeolite (ZE) was synthesized in low-temperature and alkali-fusion-hydrothermal crystallization process with fly ash (FA) containing high SiO2 and Al2O3 content as raw materials, NaOH as modifier. ZE was characterized by scanning electron microscope coupled with energy dispersive spectrometry (SEM-EDS), X-ray diffraction (XRD), X-ray fluorescence (XRF), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and Brunauer–Emmett–Teller (BET). The adsorption properties and mechanism of synthetic zeolite for Cd2+ were investigated by static adsorption experiment. The results showed that the Si-O-Si and Si-O-Al bonds in FA fractured to form [SiO4]4- and [AlO6]5- monomers after NaOH modification. The surface area of ZE increased to 21.54 m2/g. The equilibrium adsorption capacity of the Cd2+ on ZE was 49.38 mg.g-1 under the conditions of the ZE dosage of 0.1 g, Cd2+ initial concentration of 100 mg/L and adsorption time of 30 min, which more than 57.29% FA reaction. ZE adsorption of the Cd2+ removal efficiency was more 90% at pH=4~9. At 35℃, the adsorption kinetics of ZE for Cd2+ followed the pseudo-two-order kinetic equation model with rate constant of 0.0586g/(mg.min). The Cd2+ adsorption isotherm is accorded with Langmiur model, 1/n was 0.4324. The thermodynamic experiments revealed that the Gibbs free energy change △G was between -20 and 0 kJ/mol, indicating that the adsorption was a spontaneous and endothermic process. From the D-R isotherm model, the adsorption energy was more than 16 KJ/mol, which demonstrated that the adsorption of Cd2+ was a combination of physical adsorption and chemical adsorption.

Abstract:An acrylate high oil-absorbing resin was prepared by suspension polymerization of using butyl acrylate (BA) and methyl methacrylate (MMA) as monomers, dibenzoyl peroxide (BPO) as a evocating agent, diallyl phthalate (DAP) as a crosslinking agent, and polyvinyl pyrrolidone (PVP) as a dispersing agent .AOA resin was characterized by FTIR, and the saturated Oil absorption rate, and centrifugal oil retention rate of the resin were studied in different kinds of oil. The results show that AOA resin which is composed of two monomers by suspension polymerization can absorb all kinds of oil strongly, but the oil absorption capacity of different kinds of oil is not the same. The order of saturated oil absorption rate is halogenated hydrocarbon > aromatic hydrocarbon > acetone > aliphatic group and cycloalkane. It is proved that the synthesized AOA resin can be used stably at high temperature and keep a high saturated oil absorption rate repeatedly by thermogravimetric analysis（TG）and repetitive experiment environment-friendly and efficiently.

Abstract:Abstract：Polyether-modified poly(aspartic acid) superplasticizer（PEMPASP）was synthesized using polysuccinimide (PSI) and polyetheramine M2005 (M2005) as materials. FTIR was used to characterize the PEMPASP. The effects of different superplasticizers and their dosage on the fluidity and flexural strength of cement pastes were discussed and the corresponding mechanism of PEMPASP superplasticizer was studied by TOC, Zeta potential, XRD and TG-DSC. The results showed that when the molar ratio of PSI and M2005 was 1: 0.14 and the dosage of 0.35% of cement, the fluidity of cement pastes mixed with PEMPASP was 189% higher than that of cement paste mixed with PASP, and at dosage of 0.25% the flexural strength of concrete increased by 15.6% compared with that of blank cement and 17% higher than that of cement mortar containing PASP. The introduction of long-chain polyether into PASP molecules changes the charge density and the side chain structure of PEMPASP, which leads to change of the electrostatic effect and steric effect of the superplasticizer on the cement particles. The adsorption, dispersion and the hydration of cement are improved, and then the comprehensive performance of superplasticizer is improved.

Abstract:Vidarabine is well known anti-herpes andanti-herpes zoster virus drugs. It’s also the main raw material for the synthesis of downstream products such as vidarabine monophosphate and fludarabine,which are used as antideoxyribonucleic acid virus drug and B-chronic lymphocytic leukemia(B-CLL) powerful drug. So developing the synthesis of vidarabine has wide foreground on market. Vidarabinewas sffectivelysynthesized through five steps including 8-bromo, hydroxyl-sulfonylation, hydroxyl-acetylationas well as configuration inversions and dehydrazination by “one pot, two steps” methods, stating with adenosine, which can be obtained cheaply and conveniently. This method using water as reaction solvent, has some advantage such as simple craftwork, operate safely, less discharge of the three wastesand aconomic, andwith potential development in industrial production.

Abstract:Enzymatic synthesis of L-4-nitrophenylserine from glycine and 4-nitrobenzaldehyde catalyzed by recombinant L-threonine aldolase in Escherichia coli BL21(DE3) with pGEX-KG plasmid was studied. Some factors influencing enzymatic reaction, such as temperature, pH, molar ratio of glycine to 4-nitrobenzaldehyde and substrate concentration were investigated. The optimal temperature and pH value were 45oC and 8.0. The optimal molar ratio of glycine to 4-nitrobenzaldehyde was 5:1, The optimal glycine concentration was 500 mmol/L. Under the optimal conditions, the bioconversion rate of 4-nitrobenzaldehyde reached 43% after 24 h. The concentration of L-4-nitrophenylserine reached 9.72 g/L, with yield of 35%.

Abstract:Using pregnenolone as starting material, 16 steroidal derivatives Using pregnenolone as starting material, 16 steroidal derivatives containing benzimidazole heterocycle were designed and synthesized by suitable modification at C17 side chain of pregnenolone, their structures were characterized by IR, 1H NMR、13C NMR and HRMS. The antiproliferative activity of the target compounds in vitro was evaluated against KB, HeLa, HepG, CNE-2, BT474 and SKOV3 cancer cells by MTT method. The results show that some compounds possess distinct antiproliferative activities against tested cells. Among the active compounds, compound 5c and 6c show better selective activities against SKOV3 cells with IC50 values of 15.4±3.8 and 9.2±0.5 μmol/L, respectively. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.

Abstract:The free amino acid in morels was detected by automatic analyzer and the Taste Activity Value (TAV) was calculated to analyze free amino acid taste composition difference and taste characteristics in artificial cultivation and wild at different growth. The results indicated that the highest concentration of amino acids in the morels was glutamate, and there was no significant difference in free amino acids of morels from different origins. Compared with wild morels, artificial cultivation morels taste amino acids lack of aspartic acid, increased bitter amino acid of lysine, and TAV of umami aminoacids was less than wild morels. Glutamic acid, alanine, and histidine have the highest TAV in umami, sweet and bitter amino acids, respectively. Total free amino acids increased with the growth stage, and growth of early, metaphase and late stages were 7.31, 12.16 and 18.88 mg/g, respectively. Each stage has 4, 5 and 6 kinds of amino acids which have taste contribution, respectively. The taste effect of bitter amino acids enhanced from growth metaphase, which valine and lysine showed taste contribution .Both amino acids TAV values were gradually increase with the growth stages.

Abstract:Tobacco polysaccharide was extracted by ultrasonic extraction. Based on the single factor experiment , the conditions of phosphorylated tobacco polysaccharide were optimized with response surface methodology. The effects of phosphorylated tobacco polysaccharide, tobacco polysaccharides, distilled water, and propylene glycol on the moisturizing capacity of cut tobacco were studied, respectively，Finally, the sensory quality of tobacco leaf polysaccharides and phosphorylated tobacco leaf polysaccharides were tested. The results showed that the phosphate mass fraction reached 11.68% under the pH=9.0, the reaction time of 6.1 hours, and the temperature of 95 ℃. The moisturizing capacity was phosphorylated tobacco polysaccharide > tobacco leaf polysaccharide> propylene glycol> distilled water. The sensory evaluation results showed that the addition of phosphorylated tobacco leaf polysaccharide had a significant effect on improving cigarette smoking quality.

Abstract:A series of title compounds(Ⅲa-Ⅲf) were synthesized via microwave-assisted by the yield of 79.6%-84.1%, with α-hydroxyphosphonate and bromo mono-saccharide intermediates as raw materials, alkaline ionic liquid [Bmim]OH as catalyst. Their structures were confirmed by IR, 1HNMR and 13CNMR, and their antiproliferative activities were evaluated in some tumor cell lines by MTT assay. Prelimi-nary results in bioactivity tests indicated that some title compounds exhibited better activity. Among them, compounds Ⅲa, Ⅲb containing the glucose group had better inhibition effect against SGC-7901 with IC50 values of 12.9 ± 0.9μmol/L, 14.3± 1.1μmol/L respectively, compounds Ⅲc, Ⅲd containing the galactose fragments showed remarkable activities against A-549 with IC50 values of 15.9 ± 0.9μmol/L and 14.2 ± 1.3 μmol/L respectively.