Page 111 - 《精细化工》2020年第7期

第 37 卷第 7 期 精 细 化 工 Vol.37, No.7
202 0 年 7 月 FINE CHEMICALS July 2020

功能材料
基于聚六亚甲基胍盐酸盐的聚丙烯酰胺/

琼脂双网络抗菌水凝胶

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汪煜强，张孜文，杨建军 ，吴庆云，吴明元，张建安
（安徽大学 化学化工学院，安徽省绿色高分子材料重点实验室，安徽 合肥 230601）

摘要：以琼脂（Agar）、丙烯酰胺（Am）、单宁酸（TA）、氧化石墨烯（GO）为主要原料，N,N'-亚甲基双丙烯
酰胺（MBA）为交联剂制备双网络水凝胶 PAM-Agar-TA-GO（简称 PATG），其中，TA 将 GO 还原成还原氧化
石墨烯（rGO）。然后，以 TA/rGO 为微反应器与聚六亚甲基胍盐酸盐（PHMG）反应，将 PHMG 固定于水凝胶
骨架中，制备双网络抗菌水凝胶（PATGH）。对制备的水凝胶的力学性能、热力学性能、抗菌性能、抑菌性能及
生物相容性进行了测试。结果表明，琼脂的加入使水凝胶的断裂伸长率提高了 60%，抗压强度提高，力学性能
得到提高，水凝胶内部孔隙进一步缩小；经质量分数为 2.0% PHMG 水溶液浸泡后得到的抗菌水凝胶对大肠杆
菌和金黄色葡萄球菌的抑菌率均达到 99.80%以上；抗菌水凝胶在抑菌圈测试中无明显抑菌圈形成，表明 PHMG 被
固定于水凝胶中；红细胞（RBC）溶血实验表明，水凝胶溶血率均低于 5%，抗菌水凝胶有着良好的生物相容性。
关键词：聚六亚甲基胍；双网络结构；抗菌性；水凝胶；功能材料
中图分类号：TQ427.26 文献标识码：A 文章编号：1003-5214 (2020) 07-1393-07

Dual network antibacterial hydrogels based on poly(hexamethylene
biguanide)hydrochloride/polyacrylamide/agar

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WANG Yuqiang, ZHANG Ziwen, YANG Jianjun , WU Qingyun,
WU Mingyuan, ZHANG Jian′an
（College of Chemistry and Chemical Engineering, Anhui University， Key Laboratory of Green Polymer, Hefei 230601,
Anhui, China）

Abstract: Dual-network hydrogels PAM-Agar-TA-GO (referred to as PATG) were prepared by using agar
(Agar), acrylamide (Am), tannic acid (TA) and graphene oxide (GO) as raw materials, in which, TA can
reduce GO into reduced graphene oxide (rGO). Then, TA/rGO was used as a microreactor to react with
poly(hexamethylenebiguanide)hydrochloride (PHMG) and immobilized on the hydrogel skeleton to prepare
dual network antibacterial hydrogels (PATGH). The mechanical properties, thermodynamic properties,
antibacterial properties, antibacterial properties and biocompatibility of the prepared hydrogels were tested.
The results showed that the addition of agar increased the elongation at break of the hydrogel by 60%,
increased the compressive strength, further reduced the internal porosity of the hydrogel, and improved the
mechanical properties. The antibacterial rate of the antibacterial hydrogel obtained after soaking in 2.0%
PHMG aqueous solution to Escherichia coli and Staphylococcus aureus reached over 99.80%. There was
no obvious inhibition zone in the antibacterial circle test, indicating that PHMG was immobilized in
hydrogel. Hemolysis test of erythrocyte (RBC) showed that the hemolytic rate of hydrogel was below 5%,
and the antibacterial hydrogel had good biocompatibility.
Key words: poly(hexamethylenebiguanide); dual network structure; antimicrobial property; hydrogel;
functional materials

[1]
细菌感染威胁人类健康，影响人类生活方式 。 传统抗生素为了达到理想的抗菌效果需要频繁口服

收稿日期：2019-10-22; 定用日期：2020-02-26; DOI: 10.13550/j.jxhg.20191001
基金项目：安徽省 2017 年度科技计划重点项目（1704a0902018）；安徽省高校自然科学研究重点项目（KJ2016A792）
作者简介：汪煜强（1995—），男，硕士生。联系人：杨建军（1960—），男，教授，博士生导师，E-mail：andayjj@163.com。