Page 34 - 《精细化工）》2023年第10期

第 40 卷第 10 期 精 细 化 工 Vol.40, No.10
2 023 年 10 月 FINE CHEMICALS Oct. 2023

综论
木质素基载药微胶囊的研究进展

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李 雨 ，魏海英 ，喻照川 ，项舟洋 ，肖惠宁 ，刘 超 1,2*
（1. 南京林业大学，江苏省林业资源高效加工利用协同创新中心，林产化学与材料国际创新高地，江苏 南
京 210037；2. 华南理工大学制浆造纸工程国家重点实验室，广东 广州 510640；3. Department of
Chemical Engineering, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada）

摘要：近年来，基于天然生物基材料的球形颗粒由于其独特的性质，包括形状、结构和与其他材料结合的能力，
受到了越来越多的关注。木质素作为自然界中最丰富的芳香族聚合物，具有抗菌、抗病毒以及生物相容性好等
特性，在医药、化妆品和食品领域的应用潜力巨大。以球形木质素颗粒作为载体在包覆药物活性成分治疗癌症
等疾病或者包覆杀虫剂、抗菌剂等药物应用于农药的控释制剂等方面都取得了初步的研究成果。首先，简要介
绍了木质素基载药微胶囊的基本理化性质及释放影响因素；接着，概括了木质素基载药微胶囊的制备方法与对
应的特点及优势，为微胶囊的制备提供更多理论依据；然后，综述了具有生物医药应用型与化学农药应用型木
质素基载药微胶囊的应用进展及亟需解决的关键问题；最后，展望了木质素基载药微胶囊的发展前景及进一步
的工作重点。
关键词：木质素；微胶囊；纳米材料；载体；生物质
中图分类号：TQ460.4 文献标识码：A 文章编号：1003-5214 (2023) 10-2112-13

Research progress on lignin-based microcapsules
for drug protection and release

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LI Yu , WEI Haiying , YU Zhaochuan , XIANG Zhouyang , XIAO Huining , LIU Chao 1,2*
（1. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry
University, Nanjing 210037, Jiangsu China; 2. State Key Laboratory of Pulp and Paper Engineering, South China
University of Technology, Guangzhou 510640, Jiangsu China; 3. Department of Chemical Engineering, University of
New Brunswick, Fredericton, NB, E3B 5A3, Canada）
Abstract: In recent years, spherical particles based on natural bio-based materials have attracted increasing
attention due to their unique properties, including shape, structure, and ability to bond with other materials.
As the most abundant aromatic polymer in nature, lignin exhibits good antibacterial and antiviral properties
as well as biocompatibility, indicating great application potential in the pharmaceutical, cosmetic and food
fields. Preliminary research results showed that spherical lignin particles have been successfully used as
drug carriers, such as encapsulating active ingredients for the disease treatment like cancer, and insecticides
or antimicrobial agents for the controlled release of pesticides. Herein, the fundamental physicochemical
properties and release influencing factors of lignin-based drug-loaded microcapsules were briefly
introduced, followed by detailed discussions on the preparation methods, corresponding characteristics and
advantages of lignin-based drug-loaded microcapsules. The progress on the application of lignin-based
drug-loaded microcapsules in biopharmaceutical and chemical pesticide applications as well as the key
problems that need to be addressed were further reviewed. Finally, the future development directions of
lignin-based drug-loaded microcapsules were prospected.
Key words: lignin; microencapsulation; nanomaterials; carriers; biomass

收稿日期：2022-11-21; 定用日期：2023-02-02; DOI: 10.13550/j.jxhg.20221056
基金项目：国家自然科学基金（22208161）；制浆造纸工程国家重点实验室开放基金项目（202213）；南京林业大学水杉学者科研启动
基金项目（163105096）
作者简介：李 雨（1998—），男，硕士生，E-mail：liyu123@njfu.edu.cn。联系人：刘 超（1993—），男，讲师，E-mail：chaoliulc@njfu.edu.cn。