Page 44 - 《精细化工)》2023年第10期
P. 44
·2122· 精细化工 FINE CHEMICALS 第 40 卷
结构和尺寸的多样性以及化学、材料学、生物医学、 [6] YOO Y, MARTINEZ C, YOUNGBLOOD J P. Sustained dye release
农学等多学科交叉的重要性。 using poly(urea-urethane)/cellulose nanocrystal composite microcapsules
[J]. Langmuir : The ACS Journal of Surfaces and Colloids, 2017,
尽管木质素在药物负载和控释方面具有明显优 33(6): 1521-1532.
势,但目前也面临诸多挑战。有关木质素材料与芯 [7] OU M H (欧敏华), ZHANG Y D (张永德), LUO X G (罗学刚),
et al. Fabrication of electrostatic self-assembly chitosan hollow
材药物的结合机理、微胶囊抗光解、控制释放耐久 microcapsules and study of its loading and releasing properties[J].
性评价等研究目前尚处于起步阶段。因此,在载药 Chemical Industry and Engineering Progress (化工进展), 2017,
36(5): 1848-1854.
微胶囊的制备和药物控释应用中,仍存在一些问题
[8] ABULATEEFEH S R, ALKAWAREEK M Y, ALKILANY A M.
亟需解决:(1)尽管木质素在生物医学、农学应用 Tunable sustained release drug delivery system based on mononuclear
方面表现出良好的潜力,但其宽泛的相对分子质量 aqueous core-polymer shell microcapsules[J]. International Journal
of Pharmaceutics, 2019, 558: 291-298.
分布和极其复杂的分子结构为其深入研究、标准化 [9] LIANG B (梁博), SHAO J P (邵俊鹏), YANG S (杨帅), et al.
和规模化生产带来了巨大障碍。通过对木质素进行 Preparation and slow release properties of camellia oil microcapsules[J].
Fine Chemicals (精细化工), 2020, 37(12): 2541-2553.
精确分级和详细的结构表征,优选均匀的木质素分
[10] BAH M G, BILAL H M, WANG J. Fabrication and application of
子制备木质素基功能材料,可有效解决这一障碍,因 complex microcapsules: A review[J]. Soft Matter, 2020, 16(3): 570-
此,木质素的化学和加工技术仍需不断发展;(2)目 590.
[11] MENG Q Y, ZHONG S L, WANG J, et al. Advances in
前,木质素基载药微胶囊的研究主要集中在实验室 chitosan-based microcapsules and their applications[J]. Carbohydrate
阶段,尚未规模化生产,同时存在制备工艺复杂、 Polymers, 2023, 300: 120265.
[12] LI Z J (李振杰), XIONG Y M (熊亚妹), LIU Y S (刘远上), et al.
微胶囊产率低等问题,距离实际应用还有很大差距。 Study on the preparation of sweet orange oil nanocapsules by
仍需探索易制备、易扩大生产和多功能化的成熟技 complex coacervation[J]. Journal of Light Industry (轻工学报),
术,降低微胶囊生产成本,提高载药微胶囊的竞争 2022, 37(2): 44-50.
[13] LI J (李君), CHENG M M (程妹妹), MENG Y J (孟玉洁), et al.
力;(3)木质素基载药微胶囊的包封率与载药率相 Research status of the preparation of microcapsule via Pickering
较市场商品微胶囊有待提高,由于其释放条件与实 emulsion template stabilized by cellulose nanocrystals[J]. Chemical
Research (化学研究), 2021, 32(2): 183-188.
际生产适用是否相吻合还需要进一步探究,需进一 [14] PANG Y X, SUN Y N, LUO Y L, et al. Preparation of novel
步提高木质素基载药微胶囊包封与控释的稳定性 all-lignin microcapsules via interfacial cross-linking of Pickering
能;(4)木质素基载药微胶囊的应用场景有限,主 emulsion[J]. Industrial Crops and Products, 2021, 167: 113468.
[15] JIANG T D (蒋挺大). Lignin[M]. Beijing: Chemical Industry Press
要用于农业生产的杀虫、除草、植物生长激素和极 (化学工业出版社), 2009.
少数用于生物体内的药物控释等,应进一步扩大木 [16] HUANG Y M, HU Q, CUI G Q, et al. Release-controlled
microcapsules of thiamethoxam encapsulated in beeswax and their
质素基载药微胶囊的应用,如设计智能的木质素基 application in field[J]. Journal of Environmental Science and Health,
响应型药物控释剂,实现精准靶向给药,用于精准 Part B, 2020, 55(4): 342-254.
[17] SHI R F (石如芳), LUO Q P (罗秋平), HUANG J M (黄锦密), et al.
响应病虫害、癌症治疗等前沿领域;(5)木质素基
Research progress on preparation and application of microcapsules[J].
载药微胶囊相关标准化研究仍需完善,规范木质素 Guangzhou Chemical Industry (广州化工), 2022, 50(14): 17-20.
基载药微胶囊结构、形貌、尺寸、功能特性及释放 [18] GRAY A, EGAN S, BAKALIS S, et al. Determination of microcapsule
physicochemical, structural, and mechanical properties[J]. Particuology,
耐久性等性能的评价方法,引领木质素基载药微胶 2016, 24: 32-43.
囊在生物基材料领域有序健康发展。 [19] PICCININO D, CAPECCHI E, BOTTA L, et al. Layer-by-layer
preparation of microcapsules and nanocapsules of mixed polyphenols
参考文献: with high antioxidant and UV-shielding properties[J]. Biomacromolecules,
2018, 19(9): 3883-3893.
[1] BOLLHORST T, REZWAN K, MAAS M. Colloidal capsules: Nano- [20] LIU Z Q, QIE R T, LI W, et al. Preparation of avermectin
and microcapsules with colloidal particle shells[J]. Chemical Society microcapsules with anti-photodegradation and slow-release by the
Reviews, 2017, 46(8): 2091-2126. assembly of lignin derivatives[J]. New Journal of Chemistry, 2017,
[2] PENG W W, YAN X X. Preparation of tung oil microcapsule and its 41(8): 3190- 3195.
effect on wood surface coating[J]. Polymers (Basel), 2022, 14(8): 1536. [21] RAO J, CHANDRANI A N, POWAR A, et al. Release behavior of
[3] WONG C Y, AL-SALAMI H, DASS C R. Microparticles, oxyfluorfen polyurea capsules prepared using PVA and kraft lignin as
microcapsules and microspheres: A review of recent developments emulsifying agents and phytotoxicity study on paddy[J]. Green
and prospects for oral delivery of insulin[J]. International Journal of Chemistry Letters and Reviews, 2021, 14(2): 204-220.
Pharmaceutics, 2018, 537(1): 223-244. [22] ZHANG A C, WU X W, OUYANG X P, et al. Preparation of light-
[4] CHENG J L (程敬丽), ZHANG J D (张家栋), LIANG M M (梁敏 colored lignosulfonate sunscreen microcapsules with strengthened
敏), et al. Preparation and characterization of pyriproxyfen-ethyl UV-blocking and adhesion performance[J]. ACS Sustainable
cellulose microcapsule[J]. Agrochemicals ( 农药 ), 2021, (12): Chemistry & Engineering, 2022, 10(29): 9381-9388.
882-886. [23] WU C C (吴纯纯), XU J F (徐佳锋), HAN W S (韩伟胜), et al.
[5] DU G H, HU J F, ZHOU J H, et al. The study on the mechanical Application of lignin in preparation of slow/controlled-release
properties of PU/MF double shell self-healing microcapsules[J]. fertilizer[J]. Modern Agricultural Science and Technology (现代农业
Chinese Journal of Chemical Engineering, 2020, 28(5): 1459-1473. 科技), 2021, (6): 176-182.