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第 35 卷第 12 期                            精   细   化   工                                 Vol.35, No.12
             2018 年 12 月                             FINE CHEMICALS                                Dec.   2018


              功能材料
                          超临界乳液萃取法制备载槲皮素微胶囊



                                                                                            *
                            刘志军,范文华,董   超,李志义,魏   炜,刘凤霞
                                (大连理工大学  流体与粉体工程研究设计所,辽宁  大连  116023)


                 摘要:采用超临界乳液萃取法(SFEE)制得载槲皮素微胶囊,系统考察了制备过程中萃取温度、压力、CO 2 流
                 速、配制乳液参数对溶剂残留与微胶囊粒径的影响。采用顶空气相色谱法、场发射扫描电镜、Zeta 电位、FTIR
                 对溶剂残留与微胶囊进行表征。结果表明:在 313 K、9 MPa、CO 2 流速为 0.4 L/min 的条件下,处理 40 min,
                 溶剂残留可低至 59 mg/L。壁材质量浓度从 10 g/L 增加至 100 g/L 时,微胶囊粒径由 0.9 μm 升至 3.7 μm。与溶
                 剂蒸发法相比,SFEE 法可在短时间内有效去除有机溶剂,所制备的微胶囊球形度高,界面清晰,在水中稳定性好。
                 关键词:超临界乳液萃取法(SFEE);微胶囊;溶剂残留;粒径;稳定性;功能材料
                 中图分类号:TQ464      文献标识码:A     文章编号:1003-5214 (2018) 12-1981-06


                           Production of Microcapsules Loaded with Quercetin by

                                  Supercritical Fluid Extraction of Emulsions

                                                                                               *
                          LIU Zhi-jun, FAN Wen-hua, DONG Chao, LI Zhi-yi, WEI Wei, LIU Feng-xia
                 (Research and Design Institute of Fluid and Powder Engineering, Dalian University of Technology, Dalian 116023,
                 Liaoning, China)


                 Abstract: Microcapsules loaded with quercetin were prepared by supercritical fluid extraction of emulsions
                 (SFEE). The influence of process parameters, such as operating temperature and pressure, CO 2 flow rate and
                 emulsion parameters on solvent residue and particle size of microcapsules was studied. The solvent residue
                 and microcapsules were characterized by headspace gas chromatography, field emission scanning electron
                 microscopy, Zeta potential and Fourier transform infrared spectroscopy. The results showed that the solvent
                 residue can be as low as 59 mg/L after 40 min treatment at 313 K, 9 MPa and CO 2 flow rate of 0.4 L/min.
                 When the mass concentration  of wall material increased  from 10 g/L to  100  g/L, the particle size of
                 microcapsules increased from 0.9 μm to 3.7 μm. Compared with the solvent evaporation method, the SFEE
                 method can effectively remove the organic solvent in a short time and the prepared microcapsule has high
                 sphericity, clear interface and good stability in water.
                 Key words: supercritical fluid extraction of emulsions (SFEE); microcapsule; solvent residue; particle size;
                 stability; functional materials
                 Foundation item: National Natural Science Foundation of China (21606037)


                                                  [1]
                 槲皮素是生物类黄酮,具有抗氧化性 、抗肿                          需要繁琐的后处理过程,此外,所得微胶囊粒径不
              [2]
                      [3]
            瘤 、抗炎 、止咳、降血脂、增加免疫力等多种生                            均匀,通常需要进行筛分处理。这在一定程度上限
            物活性,应用前景广阔。在实际应用中,由于槲皮                             制了槲皮素的安全、高效使用。
            素水溶性低、在自然条件下易被氧化,其口服生物                                 超临界乳液萃取法(Supercritical Fluid Extraction
                                   [4]
                                                       [5]
            利用率在小鼠中低于 17% ,在人体中低于 1% ,                         of Emulsion,SFEE)作为利用超临界流体制备微胶
            需要被加工成微胶囊使用。传统制备微胶囊方法如                             囊的一种新兴方法可以看作是 SAS 法(Supercritical
            溶剂蒸发法、喷雾干燥法等易造成有机溶剂的残留,                            anti-solvent technology,超临界流体抗溶剂法,SAS)


                 收稿日期:2018-05-08;  定用日期:2018-07-30; DOI: 10.13550/j.jxhg.20180334
                 基金项目:国家自然科学基金(21606037)
                 作者简介:刘志军(1969—),男,教授,博士。联系人:刘凤霞(1976—),女,副教授,博士,E-mail:liufx@dlut.edu.cn。
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