Page 128 - 201902
P. 128

·294·                             精细化工   FINE CHEMICALS                                  第 36 卷

            3    结论                                            [9]   Tu Zhiying (涂志英), Wu Bin (武斌), Zhu Jiawen (朱家文). Study
                                                                   on  the  preparation  of  rifamycin  O  by  oxidation  of  rifamycin  B[J].
                                                                   Chemical World (化学世界), 2007, 48(6): 366-369.
                 (1)以乙酸丁酯/水两相体系代替传统工艺中                         [10]  Löw S A, Nestl B M, Weissenborn M J, et al.Process investigations
            的水基体系,可提高原料的浓度及纯度,减少氧化                                 on  the  one-pot  synthesis  of  rifamycin  S  avoiding  chlorinated
            过程中副反应,提高产物的收率及选择性。                                    solvents[J]. Organic Process Research & Development, 2015, 19(11):
                                                                   1544-1547.
                 (2)考察的 5 种氧化剂中,H 2 O 2 、CH 3 COOOH            [11]  Lu Jiuhua (陆久华). A study on the reactivity of rifamycin S and its
            以自由基氧化为主,易发生链式反应,降解目标产                                 structure-activity relationship[J]. Chinese Journal of Antibiotics (中
                                                                   国抗生素杂志), 1985,10(4): 230-233.
            物;NaNO 2 氧化效果一般,反应时间太长,不适于                         [12]  Cabral J M S, Aeres-Barros M R, Pinheiro H. Biotransformation in
            工业化应用。相比 Ca(ClO) 2 ,NaClO 氧化效果更好,                      organic media by enzymes and whole cells[J]. Biotechnology, 1999,
                                                                   59(3): 133-143.
            选择性更高,得到产品的收率高,是该工艺过程中
                                                               [13]  Wang  Lili  (王李礼),  Chen  Yijun  (陈依军). Enzymatic catalysis in
            一种合适的氧化剂。                                              non-aqueous solvents[J]. Chinese Journal of Biotechnology (生物工
                 (3)以 NaClO 为氧化剂非均相氧化 SV 制备 S                      程学报), 2009, 25(12): 1789-1794.
                                                               [14]  Zhao Deming (赵德明), Li Zhifa (李治发), Zhang Yan (张岩), et al.
            的较优条件为:c(NaClO)=0.3206 mol/L,NaClO 与                   Preparation of rifamycin S: CN105237548A[P]. 2016-01-13.
            SV 物质的量比为 1.4∶1.0,=30  ℃,pH=12.3,反                [15]  Xue  Jun  (薛军).  New  process  for  water  extraction  of  rifamycin:
                                                                   CN881055263[P]. 1988-05-25.
            应 12 min。此时,利福霉素 S 粗品收率、选择性、
                                                               [16]  Wuzhou Pharmaceutical Factory (五洲药厂). A preparation method
            空时收率分别为 89.02%、92.42%、139.60 g/(Lh),                  of rifamycin S sodium: CN1045993A[P]. 1990-10-10.
            与传统工艺相比,收率、选择性分别提高了 3.61%、                         [17]  Pasqualucci C R, Bonfanti G, Turolla C. Method for extracting and
                                                                   isolating  rifamycin  O  from  fermentation  broths  of  rifamycins:US
            6.74%,空时收率增加 122.85 g/(Lh)。                           3847903[P]. 1974-11-12.
                                                               [18]  Pasqualucci  C  R,  Bonfanti  G,  Scarpitta  G.  A  process  for  preparing
            参考文献:                                                  rifamycin  S  by  hydrolysis  of  rifamycin  O:US1431034[P].  1976-
                                                                   01-20.
            [1]   Aristoff P A, Garcia G A, Kirchhoff P D, et al. Rifamycins-obstacles
                 and opportunities[J]. Tuberculosis, 2010, 90(2): 94-118.   [19]  Chen J, Sun P, Zhang Y, et al. Multiple roles of Cu(Ⅱ) in catalyzing
            [2]   Yu Wenhe (俞文和),  Yang  Jigen  (杨纪根).  Antibiotic  technology   hydrolysis  and  oxidation  of  β-lactam  antibiotics[J].  Environment
                 [M]. Shenyang: Liaoning Science and Technology Press (辽宁科学  Science and Technology, 2016, 50 (22): 12156-12165.
                 技术出版社), 1989: 461-462.                        [20]  Beijing  Normal  University  (北京师范大学),  Huazhong  Normal
            [3]   Heinz G F, Tin-Wein Yu. Rifamycin-mode of action, resistance, and   University (华中师范大学), Department of Inorganic Chemistry Nanjing
                 biosynthesis[J]. Chemical Reviews, 2005, 105(2): 621-632.   Normal  University  (南京师范大学无机化学教研室).  Inorganic
            [4]   Burman  D  W  J,  Gallicano  K,  Peloquin  C.  Comparative  pharmaco   chemistry:  fourth  edition[M].  Beijing:  Beijing  Higher  Education
                 kinetics  and  pharmaco  dynamics  of  the  rifamycin  antibacterials  [J].   Press (北京高等教育出版社), 1993, 475-476.
                 Clinical Pharmaco Kinetics, 2001, 40(5): 327-341.   [21]  Zheng  Hu  (郑虎).  Physical  chemistry:  fourth  edition[M].  Beijing:
            [5]   Xue Shouli (薛守礼), Du Li (杜莉), Du Mingshan (杜明山), et al.   People's Medical Publishing House (人民卫生出版社). 2000: 292.
                 Method  for  synthesizing  rifampicin  in  one  pot:  CN1690095A[P].   [22]  Wang Wanlin (王万林). Research progress on the stability of aqueous
                 2005-11-02.                                       sodium hypochlorite solution[J]. Inorganic Chemicals Industry (无机
            [6]   Meng Shuxun (孟树勋). Method for producing rifamycin S directly   盐工业), 2007, 39(9): 12-14.
                 from fermentation filtrate: CN102140102A[P]. 2011-08-03.   [23]  Liu Shaoyou (刘少友), Huang Xueli (黄雪丽), Zhen Weijun (甄卫
            [7]   Jiang  Degang  (蒋德刚),  Mao  Zhigao  (毛志高), Shi Xueyan  (史雪  军), et al. Macrokinetic studies on decomposition reaction of sodium
                 岩). A new process for producing rifamycin S: CN102942574B[P].   hypochlorite liquor by atomic matrix[J]. Chlor-Alkali Industry (氯碱
                 2015-06-03.                                       工业), 2013,49(5): 30-32.
            [8]   Yin Tiantian (尹恬恬), Zhang Xiaoyan (张晓艳), Li Lele (李乐乐).   [24]  Zhou Xiangwu (周相武), Wang Xiaojun (汪晓军), Liu Jiao (刘娇),
                 Talking about the mechanism of chloride ion corrosion of stainless   et al.  Studies  on  the  oxidizing  property  of  sodium  hypochlorite
                 steel[J]. Undertaking & Investment (投资与创业), 2016, (5): 174-175.   solution[J]. Chlor-Alkali Industry (氯碱工业), 2006,42(8):28-30.
   123   124   125   126   127   128   129   130   131   132   133