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第 4 期 代明允，等: 2-羟基-3-烯丙氧基丙基羟乙基纤维素的制备及温度敏感性能 ·601·

通过扫描电镜更加直观地观察了 HAPEC 生物 子强度的增大，LCST 呈下降趋势。
降解前后形貌的变化，图 7 是 HAPEC 未降解时和 （2）两亲性的 HAPEC 在水溶液中可自组装形
降解 30、70 和 90 d 后的 SEM 图片。 成胶束。利用荧光光谱、动态光散射研究了 HAPEC
未降解时，HAPEC 样品表面光滑，呈完整片状； 的自组装行为。结果表明，在 HAPEC 水溶液浓度
降解 90 d 后，HAPEC 形貌发生了明显的改变，即 高于 CMC 后，HAPEC 可自组装形成胶束，并且
表面粗糙、多孔甚至塌陷，这表明 HAPEC 具有良 HAPEC 的 CMC 随疏水基团取代度的增加而降低。
好的生物降解性。 当 HAPEC 的取代度从 1.11 提高到 2.71 时，CMC
从 0.145 g/L 下降到 0.021 g/L。
（3）HAPEC 具有良好的生物降解性。HAPEC
降解 90 d 后，HAPEC 的形貌变化明显，生物降解
程度可达到 36.5%。

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（1）将疏水化试剂烯丙基缩水甘油醚通过醚化 [12] Wang Q, Gu Z, Jamal S, et al. Hybrid hydroxyapatite nanoparticle
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HAPEC 的取代度从 1.30 增大到 2.71 时，LCST 从 2016, 27(17): 1698-1711.

64.3 ℃降低到 28.5 ℃。随着 HAPEC 浓度或溶液离 （下转第 608 页）