Page 108 - 《精细化工》2021年第12期
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·2470· 精细化工 FINE CHEMICALS 第 38 卷
质结构）促进了细胞的黏附和快速增殖。负载的 Ss 到 58%，在 7 d 内能够实现药物长效释放，药物累
也促进了细胞的增殖，Ss 含量为 20%的载药纳米纤 积释放量可达 77%；纳米纤维膜能够有效地抑制大
维膜增殖效果最好，7 d 细胞活性达到 171%，较未 肠杆菌和金黄色葡萄球菌；纳米纤维膜具有较好的
负载 Ss 的载药纳米纤维膜（146%）高 25%，较 PAE 生物相容性，Ss 含量为 20%的纳米纤维膜增殖效果
与 Ss 均未负载的纳米纤维膜（133%）高 38%。这 最好，细胞增殖率达到 171%，较未添加 Ss 的纳米
是因为，Ss 中含有生物活性基序 4RepCT [26] ，具有 纤维膜的细胞活性高 25%，较 PAE 与 Ss 均未负载
良好的生物相容性。并且随着 Ss 含量的增加，纳米 的纳米纤维膜细胞活性高 38%，在细胞增殖过程中
纤维膜的亲水性得到改善，共同促进细胞黏附，同 Ss 和 PAE 起到了协同作用。
时 PAE 能够促进成纤维细胞分泌生长因子，促进细
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胞增殖。纳米纤维膜的核壳结构使得 Ss 和 PAE 在
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制药物突释，Ss 含量为 20%时，48 h 内药物释放达 （下转第 2545 页）
