Page 35 - 《精细化工》2021年第5期
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第 38 卷第 5 期                             精   细   化   工                                  Vol.38, No.5
             202 1 年 5 月                             FINE CHEMICALS                                 May  2021


              综论
                          光化学 AOPs 去除水中抗生素抗性菌和


                                            抗性基因研究进展



                                                                                            *
                            王佳豪,田   湉,李家成,许   锴,林子增,王   郑
                                      (南京林业大学  土木工程学院,江苏  南京  210037)

                 摘要:抗生素的滥用所导致的细菌耐药性增强以及抗性基因污染问题,对人类健康和生态安全造成了极大的威
                 胁,如何高效地去除水中抗生素抗性菌(简称 ARB)和和抗生素抗性基因(简称 ARGs)成为当前研究重点。
                 光化学高级氧化技术(简称 AOPs)可以利用光辐照产生具有强氧化性的活性氧物种来氧化分解水中难降解有机
                 污染物,对于水中抗性菌和抗性基因的去除具有广阔的应用前景。该文首先介绍了抗生素抗性基因传播扩散机
                 制及污染现状,其次对光化学 AOPs 应用于去除水中抗生素 ARB 和 ARGs 的研究进展进行归纳,并分析了影响
                 去除效果的因素及其应用的局限性,最后指出未来应加强对于光化学 AOPs 灭活的氧化损伤机制以及与规模化
                 实际工程应用相结合的研究。
                 关键词:抗性菌;抗性基因;光化学;高级氧化技术;自由基;失活
                 中图分类号:X52;X703.1      文献标识码:A      文章编号:1003-5214 (2021) 05-0889-09


                      Research progress on removal of antibiotic resistant bacteria and
                                     genes in water by photochemical AOPs


                                                                                              *
                          WANG Jiahao, TIAN Tian, LI Jiacheng, XU Kai, LIN Zizeng, WANG Zheng
                          (College of Civil Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China)


                 Abstract: The abuse of antibiotics causes the increase of bacteria resistance and the pollution of resistance
                 genes, which poses  a great threat  to  human health  and ecological security. How to efficiently  remove
                 antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in water has become the current
                 research focus. Photochemical advanced oxidation processes (AOPs) can use light irradiation to generate
                 active  oxygen  species with strong oxidizing properties to oxidize  and decompose difficult-to-degrade
                 organic pollutants in water, which has broad application prospects for the removal of resistant bacteria and
                 resistant genes in water. Firstly, the spreading mechanism of antibiotic resistance genes and the status of
                 pollution are introduced. Secondly, the research progress of photochemical AOPs in the removal of ARB
                 and ARGs in water is isummarized. Then, the factors affecting the removal effect of photochemical AOPs
                 and its application limitations are analyzed. Finally, it is pointed out that the research on the oxidative
                 damage mechanism of  AOPs inactivation  and its combination  with large-scale  practical  engineering
                 application should be strengthened in the future.
                 Key words: antibiotic resistant bacteria; resistance genes; photochemistry; advanced oxidation processes;
                 free radical; deactivation


                 近年来,抗生素被广泛应用于畜牧、水产养殖                          生素的滥用,本就不易降解的抗生素以痕量形式残
            及人类和动物疾病治疗等领域。然而,随着大量抗                             留于环境中并形成持续的选择压力,诱导细菌产生


                 收稿日期:2020-12-22;  定用日期:2021-02-02; DOI: 10.13550/j.jxhg.20201207
                 基金项目:国家自然科学基金资助项目(51608272);江苏高校优势学科建设工程资助项目(PAPD)
                 作者简介:王佳豪(1996—),男,硕士生,E-mail:1252225932@qq.com。联系人:王   郑(1978—),男,教授,E-mail:wangzheng@
                 njfu.edu.cn。
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