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·946· 精细化工 FINE CHEMICALS 第 38 卷

[4] VEETIL J V, YE K. Tailored carbon nanotubes for tissue engineering
applications[J]. Biotechnology Progress, 2009, 25(3): 709-721.
[5] KANFIMALLA V B, TRIPATHI V S, JU H. A conductive ormosil
encapsulated with ferrocene conjugate and multiwall carbon nanotubes
for biosensing application[J]. Biomaterials, 2006, 27(7): 1167-1174.
[6] SHVEDOVA A A, KISIN E R, PORTER D, et al. Mechanisms of
pulmonary toxicity and medical applications of carbon nanotubes:
Two faces of Janus[J]. Pharmacology & Therapeutics, 2009, 121(2):
192-204.
[7] SMART S K, CASSADY A I, LU G Q, et al. The biocompatibility of
carbon nanotubes[J]. Carbon, 2006, 44(6): 1034-1047.
[8] ALI BOUCETTA H, KOSTARELOS K. Pharmacology of carbon
nanotubes: Toxicokinetics, excretion and tissue accumulation[J].
Advanced Drug Delivery Reviews, 2013, 65: 2111-2119.
[9] CHOPRA N G, LUYKEN R J, CHERREY K, et al. Boron nitride
nanotubes[J]. Science, 1995, 269: 966-967.
[10] LI X, ZHI C Y, HANAGATA N, et al. Boron nitride nanotubes
functionalized with mesoporous silica for intracellular delivery of
chemotherapy drugs[J]. Chemical Communications, 2013, 49(66):
7337-7339.
[11] LAHIRI D, ROUZAUD F, RICHARD T, et al. Boron nitride nanotube
reinforced polylactide-polycaprolactone copolymer composite:
Mechanical properties and cytocompatibility with osteoblasts and
macrophages in vitro[J]. Acta Biomaterialia, 2010, 6: 3524-3533.
[12] MENICHETTI L, DE MARCHI D, CALUCCI L, et al. Boron nitride
nanotubes for boron neutron capture therapy as contrast agents in
图 8 不同质量浓度 BNNTs-OH 孵育不同时间对 L02 细
magnetic resonance imaging at 3T[J]. Applied Radiation and
胞存活率的影响 Isotopes, 2011, 69: 1725-1727.
Fig. 8 Effects of different BNNTs-OH mass concentrations [13] HORVÁTH L, MAGREZ A, GOLBERG D, et al. In vitro investigation
on the viability of L02 cells after incubation for of the cellular toxicity of boron nitride nanotubes[J]. ACS Nano,
different time 2011, 5: 3800-3810.

[14] CHEN X, WU P, ROUSSEAS M, et al. Boron nitride nanotubes are
3 结论 noncytotoxic and can be functionalized for interaction with proteins
and cells[J]. Journal of the American Chemical Society, 2009, 131:
890-891.
采用盐酸和浓硝酸先后处理，除去了原始 BNNTs
[15] KOI N, OKU T, INOUE M, et al. Structures and purification of
所含的催化剂杂质，并进行羟基化修饰，获得了尺 boron nitride nanotubes synthesized from boron-based powders with
寸较短的 BNNTs-OH。浓硝酸的利用大大缩短了羟 iron particles[J]. Journal of Materials Science, 2008, 43: 2955-2961.
[16] LI L H, CHEN Y. Superhydrophobic properties of nonaligned boron
基化时间。羟基化的 BNNTs 在水溶液中具有很好的
nitride nanotube films[J]. Langmuir, 2010, 26(7): 5135-5140.
分散性，平均水合粒径约为 1246.7 nm。荧光光谱表 [17] MUTZ M, EASTWOOD E, DADMUN M D. Quantifying the
明，BNNTs-OH 具有特殊的荧光特性，在一定的激 solubility of boron nitride nanotubes and sheets with static light
发波长下可以实现细胞内的定位。细胞毒性测试表 scattering and refractometry[J]. Journal of Physical Chemistry C,
2013, 117(25): 13230-13238.
明，经过酸化处理，截短和氧化后的 BNNTs-OH 对 [18] ZHI C Y, BANDO Y, TERAO T, et al. Chemically activated boron
人胚胎肝细 胞系 L02 细胞未呈现 细胞毒性。 nitride nanotubes[J]. Chemical Asian Journal, 2009, 4: 1536-1540.
[19] CIOFANI G, GENCHI G G, LIAKOS I, et al. A simple approach to
BNNTs-OH 是一种具有生物相容性的纳米材料，为
covalent functionalization of boron nitride nanotubes[J]. Journal of
其在生物领域的应用奠定了前期工作基础。 Colloid and Interface Science, 2012, 374(1): 308-314.
[20] PAN A, CHEN Y J. Large-scale fabrication of boron nitride nanotubes
参考文献： with high purity via solid-state reaction method[J]. Nanoscale Research
[1] HUANG H, YUAN Q, SHAH J S, et al. A new family of Letters, 2014, 9: 555.
folate-decorated and carbon nanotube-mediated drug delivery [21] ZHANG H X (张会鲜), HE Q Y (何琪杨). Optimization study on the
system: Synthesis and drug delivery response[J]. Advanced Drug detection of tumor cell proliferation with CCK-8 method [J]. Journal
Delivery Reviews, 2011, 63: 1332-1339. of Pharmaceutical Research (药学研究), 2016, 35(2): 63-66.
[2] WELSHER K, LIU Z, DARANCIANG D, et al. Selective probing [22] HOU L X, CHEN Z G, LIU X H, et al. X-ray photoelectron
and imaging of cells with single walled carbon nanotubes as spectroscopy study of cubic boron nitride single crystals grown under
near-infrared fluorescent molecules[J]. Nano Letters, 2008, 8(2): high pressure and high temperature[J]. Applied Surface Science,
586-590. 2012, 258(8): 3800-3804.
[3] MENG L J, ZHANG X K, LU Q H, et al. Single walled carbon [23] YANG L J (杨丽娇), WANG J L (王金良), YANG C T (杨成涛),
nanotubes as drug delivery vehicles: Targeting doxorubicin to et al. Photoluminescence principle and research progress of silicon
tumors[J]. Biomaterials, 2012, 33(6): 1689-1698. nanowire[J]. Materials Reports (材料导报), 2012, 26(21): 135-141.