Page 29 - 《精细化工》2023年第3期

第 3 期 李雨晴，等: 硅酸钙类骨水泥改性研究进展 ·485·

FB 为成纤维细胞；MP 为巨噬细胞；GC 为异物巨细胞
图 6 PMMA 糊剂（a、b、c）、C 3 S 糊剂（d、e、f）、F-C 3 S 糊剂（g、h、i）植入大鼠肌肉的组织学图片 [96]
Fig. 6 Histological micrographs of muscle tissues (rat) around PMMA paste (a, b, c), pure C 3 S paste (d, e, f) and F-C 3 S
paste (g, h, i) [96]

injectable bioactive borate glass cement to heal bone defects in a
3 结束语与展望 rabbit femoral condyle model[J]. Materials Science and Engineering,
2017, 73(C): 585-595.
CSC 作为一种胶凝性钙基骨移植材料，可以被 [4] AGHYARIAN S, HU X B, LIEBERMAN I H, et al. Two novel high
performing composite PMMA-CaP cements for vertebroplasty: An ex
注射到骨腔或骨缺损部位，硬化后，可在原位形成 vivo animal study[J]. Journal of the Mechanical Behavior of
固体材料，其力学性能、封闭性能和骨再生能力得 Biomedical Materials, 2015, 50: 290-298.
[5] QI X, PEI P, ZHU M, et al. Three dimensional printing of calcium
到了研究者们的认可。但仍有些问题未解决，例如： sulfate and mesoporous bioactive glass scaffolds for improving bone
如何提高 CSC 的固化性能；在提高固化性能的基础 regeneration in vitro and in vivo[J]. Scientific Reports, 2017, 7: 42556.
[6] SHI H S, ZHANG W Q, LIU X, et al. Synergistic effects of citric
上，如何避免其局部 pH 过高导致的感染；体外降
acid-sodium alginate on physicochemical properties of α-tricalcium
解和体内降解是否具有一致性等。这些问题主要是 phosphate bone cement[J]. Ceramics International, 2019, 45(2):
由于 CSC 本身的化学性质和固化产物的相组成所决 2146-2152.
[7] SUN H L, LIU C, LI X W, et al. A novel calcium phosphate-based
定的。先前的研究主要集中在对 CSC 体系自身组成 nanocomposite for the augmentation of cement-injectable cannulated
的调整上，常局限于某方面性能的改进；目前，有 pedicle screws fixation: A cadaver and biomechanical study[J].
Journal of Orthopaedic Translation, 2020, 20: 56-66.
少数研究将 CSC 与 CPC、CS 和 MPC 等几种骨水泥 [8] WU T T, SHI H S, LIANG Y Y, et al. Improving osteogenesis of
体系进行交叉复合，这是具有良好应用前景的研究 calcium phosphate bone cement by incorporating with manganese
doped β-tricalcium phosphate[J]. Materials Science and Engineering,
思路，但是研究内容尚不系统。
2020, 109(C): 110481.
基于复合材料的多元组成，其性能不是单一组 [9] MYRIAM L F, CHARLOTTE M, FRANCOIS XAVIER L, et al. In
分起作用，而是多种成分的协同作用。因此，如果 vivo resorption of injectable apatitic calcium phosphate cements:
Critical role of the intergranular microstructure[J]. Journal of
能在研究不同单一体系骨水泥的各种性能（理化性 Biomedical Materials Research, Part B: Applied Biomaterials, 2020,
能、降解性能、生物相容性、生物活性）基础上， 108(2): 367-376.
[10] TAN Y S, DONG J M, YU H F, et al. Study on the injectability of a
进一步研究几种骨水泥体系之间性能上的互补关
novel glucose modified magnesium potassium phosphate chemically
系，将有助于骨水泥的优化设计，并最终获得综合 bonded ceramic[J]. Materials Science and Engineering, 2017, 79(C):
性能优良的无机复合骨水泥。 894-900.
[11] YU S C, LIU L L, XU C, et al. Magnesium phosphate based cement
with improved setting, strength and cytocompatibility properties by
参考文献：
adding Ca(H 2PO 4) 2•H 2O and citric acid[J]. Journal of the Mechanical
[1] TURNBULL G, CLARKE J, PICARD F, et al. 3D bioactive composite Behavior of Biomedical Materials, 2019, 91: 229-236.
scaffolds for bone tissue engineering[J]. Bioactive Materials, 2018, [12] GELLI R, MATI L, RIDI F, et al. Tuning the properties of
3(3): 278-314. magnesium phosphate-based bone cements: Effect of powder to
[2] ZHANG Q, CHEN L, CHEN B, et al. Lithium-calcium-silicate liquid ratio and aqueous solution concentration[J]. Materials Science
bioceramics stimulating cementogenic/osteogenic differentiation of and Engineering, 2019, 95(C): 248-255.
periodontal ligament cells and periodontal regeneration[J]. Applied [13] WAN Q Q, SUN J L, MA Y X, et al. Immunomodulatory effects of
Materials Today, 2019, 16: 375-387. tricalcium silicate-based cements on osteogenesis[J]. Applied Materials
[3] CUI X, HUANG W H, ZHANG Y D, et al. Evaluation of an Today, 2021, 24: 101145.