Page 200 - 《精细化工》2023年第4期

g886g ㇫㏳ࡃጒ FINE CHEMICALS
ఫ 13 ὎᠌㗰㗍⊵ࡃᬣ䬡ᄦ LA ㉜⼜䛷ᩫ⢴⮱ᒞ৺
Fig. 13 Effect of simulated gastrointestinal digestion time
on cumulative release of LA
⩞ఫ 13 जВⰸܧ喑ౕݺ 120 min ڲ LA-Zein-MC
㏠ㆠㆿၽ͚⮱ LA হ⍥⻨ LA ౕ὎᠌㗰⋟͚㉜⼜䛷ᩫ
⢴ܳݘͧ 57.1%হ 86.8%ȡऻ 120 min ڣౕ὎᠌㗍⋟
͚㉜⼜䛷ᩫ⢴ܳݘͧ 76.1%হ 88.6%ȡ䔆᭜఍ͧ喑
ౕ὎᠌㗰⋟͚㗰㯸⮪䚣⮱ႅౕҬ LA-Zein-MC ㏠ㆠ
ㆿၽใภ̷⮱䚗㯸⮪䚥䧍㷘ᄼ䘕ܳܳ㼐喑఍ₑ䕍᜽
LA ใ≮喑㔹ౕ⩞὎᠌㗰⋟䒙ݝ὎᠌㗍⋟ᬣ喑LA ࣵ
㷘๔䛼䛷ᩫܧᲒ喑䔆᭜⩞λᒀ LA-Zein-MC ㏠ㆠㆿ
ၽ⩞ᑧ䚥ᕔ⮱㗰⋟⣜ධ͚䒙⼨ݝ䓾͚ᕔ⮱ᄼ㗍⣜ධ
͚ᬣ喑pH ⮱⾮अ䕍᜽ LA-Zein-MC ㏠ㆠㆿၽใภ㏼
䓴̭㈨݄अࡃ㔹䕍᜽㼐Ҁ喑ϻ㔹ᄩ㜡 LA 䛷ᩫ喑ᅪ
ノ㏠ㆠㆿၽใภ⮱㐀Ჱ㷘ⵡ౼喑ិ㘝㯸⮪䚣Ⅱ㼐⩌
᜽๔ᄼ⮱็㗪䨫喑ѳ䔆ψ㗪ΌजВ̻ LA ࣾ⩌䲋ڞ
Ф㐀व喑ᰶݖλ LA ⮱Ԋ៑হ॥ᩣ [31] ȡ㔹ౕ὎᠌㗰
⋟ݺ 30 min喑⍥⻨ LA ႅౕ⾮䛷⣝䆎喑LA ㉜⼜䛷ᩫ
⢴䓫ݝ 80%͸ऻॵ⣝㑀ᚏ䛷ᩫ⮱䊸߬ȡLA-Zein-MC
㏠ㆠㆿၽजВ䭺ѻ LA ⮱䛷ᩫ䕌⢴喑Ꭳ䓫ݝजᣔ䛷
ᩫ᩵᳉喑䄡ᬻ᱗ᲒजВ҉ͧ᳽ψ⪼Ⅱ≨ᕔࡃव➖⮱
ऐ᰺䒪Ҁ [32] ȡᣔݣ䛷ᩫ᩵Ꮑज㘪᭜⩞λ LA ̻ Zein
㏠ㆠڲ䘕⪼Ⅱࡧഌ͸䬡ڤᰶ䒰ᑧ⮱⪼ⅡⰥο҉⩕হ
⅏䩛喑́ใภΌ២ᡎγ䚣⮱ܳ㼐҉⩕ȡ䔆̻ LIU ぶ
ᄳ༉叱㉍࠲㸦ౕ⢶ㆠ叱㯸⮪-⊤㬨䚥䧍㏠ㆠㆿၽ͚
ᣔݣ䛷ᩫ⮱㐀᳉̭㜡ȡ
3 㐀䃧
᱙᪴ݖ⩕ࣺ⏣ݯ∂ݣิγ࠲೸ LA ⮱ Zein ㏠ㆠ
ㆿၽ喑हᬣᄳ MC ࠲㸦ౕ㏠ㆠㆿၽ㶕䲏ڞ↶⋭ȡВ
ㆿᒱȠ Zeta ⩢ѺȠ PDI ͧ㶎䛼ᠴᴴ喑⶛Ⴧγ
LA-Zein-MC ㏠ㆠㆿၽᰭҠݣิ䙺℁ͧ m(Zein)ń
m(MC)=1ń2.4Ƞm(Zein)ńm(LA)=25ń1ȡSEM 㐀᳉
㶕ᬻ喑㷘 MC ԛ亝⽠Ⴧऻ⮱㏠ㆠㆿၽᰡߍٶ⏾́ܳ
᪐ȡFTIR 㐀᳉㶕ᬻ喑LA হ Zein ᒏ᜽γ⪼ⅡᕔⰥο
҉⩕Ƞᒏ᜽⅏䩛喑LA 㷘࠲೸ౕ Zein ڲ䘕ȡXRD 㐀
᳉㶕ᬻ喑LA ⩞ᮣҀ䒙ࡃͧᬍჇᒏȡDSC 㐀᳉᭫⹧喑
LA ⮱⛁◦⊵๞喑ज㘪᭜఍ͧڣ㷘࠲೸ౕڲ䘕ȡLA
す 40 ࢤ
࠲ᄮ⢴ͧ 56.17%喑䒪㢜䛼ͧ 0.56%ȡ☚⽠Ⴧᕔ჋侹
㐀᳉㶕ᬻ喑㷘 MC 㺳Ⰳ⮱ Zein ㏠ㆠㆿၽ㶕⣝ܧ㞜ສ
⮱⽠Ⴧᕔȡ఍ₑ喑ݖ⩕ MC ԛ亝⮱ Zein ҉ͧ LA ⮱
䒪ҀजВ᣽倅 LA ⮱⽠Ⴧᕔহᣔݣ䛷ᩫ喑ͧ⪼Ⅱᕔ
➖䉕⮱䓽䓀᣽ӈγ᫝ᕊ䌜ȡ
࣯㔰᪴⡛喟
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喍̸䒙す 901 䶢喎