Page 197 - 《精细化工》2023年第4期

す 4 ᱌ ᑍచచ喑ぶ: ✂叓 ȕ-㦎㖇㈃-䚗㯸⮪-⢶ㆠ䚴⏣㯸⮪㏠ㆠㆿၽ⮱ݣิࣷڣ䉌䒪 Į-⶘䓈䚥 g883g

㶕 2 Zein হ LA 䛼䉕䛼℁ᄦ LA-Zein-MC ㏠ㆠㆿၽ LA Zein ㏠ㆠㆿၽࢂ⠙ܳ᪐喑㶕䲏ٶ⏾喑ڣ㶕䲏ᰶܦ䲏
࠲ᄮ⢴হ䒪㢜䛼⮱ᒞ৺ ᒏ᜽ㆨѩλ“⩉⩉వ”⮱ᒏᔮȡใ㶕䲏⇎ᰶᬻ᭫⮱㷯
Table 2 Effects of mass ratio of Zein to LA on ㏦ᝃႁ䯆喑 㶕ᬻᄦ LA ᰶ䒰ສ⮱Ԋ៑҉⩕ ȡ
encapsulation efficiency and drug-loading
efficiency of LA in LA-Zein-MC nanoparticles BERTOLINI ぶ [13] 䛴⩕䭬៶ќ㘣҉ͧ䒪ҀΌܧ⣝͚
m(Zein)ńm(LA) 10ń1 25ń1 50ń1 ᓰܦ䮤⮱㐀᳉ȡₑใ喑RIBEIRO ぶ [14] ⮱ⵁ⾣Όॵ⣝
࠲ᄮ⢴/% 17.38 56.17 58.79 Ⱕह⮱㐀᳉ȡ
䒪㢜䛼/% 0.37 0.56 0.63 2.5 FTIR ܳᲽ
ఫ 7 ͧ LAȠZeinȠLA-Zein ㏠ㆠㆿၽȠLA-Zein-
⩞㶕 2 ज㻮喑ᒀ m(Zein)ńm(MC)=1ń2.4 ̺अ MC ㏠ㆠㆿၽ⮱ FTIR 䅞ఫȡϻఫ 7 जВⰸܧ喑LA
–1
ᬣ喑䮼Ɑ LA ⩕䛼⮱䔽⌽ۼᄼ喑LA ࠲ᄮ⢴হ䒪㢜䛼 ౕ 2927 cm ั⮱➦ᒮ॥ᩣምͨ㺮ͧ—OH ⮱ѥ㑖ᡜ
–1
౴䔽⌽෋๔ȡᒀ m(Zein)ńm(LA)=50ń1 ᬣ喑ܧ⣝ᰭ ߕ喠ౕ 1695 cm ั⮱॥ᩣምᑿᆋλ C==O 䩛⮱ѥ㑖
–1
๔⮱࠲ᄮ⢴হ䒪㢜䛼喑ܳݘͧ 58.79%হ 0.63%ȡ䔆 ᡜߕ喠ౕ 938 cm ั⮱॥ᩣምͧ O—H 䩛⮱ѥ㑖ᡜ
ज㘪᭜఍ͧ Zein হ MC ᒏ᜽ภᵥ㐀Ჱᬣ喑㏠ㆠㆿၽ ߕ [15] ȡZein ౕ 3356 cm ั⮱➦ᒮ॥ᩣምͧ—OH ⮱
–1
ڲ䘕ᒏ᜽⪼Ⅱᕔ⾧䬡喑ₑᬣ⪼Ⅱᕔ➖䉕 LA 㷘࠲೸ ѥ㑖ᡜߕ [16] 喑LA-Zein ͚⮱⅏䩛⮱॥ᩣምࣾ⩌㏏⼨喑
䔈ࣨ喑ѳ⩞λ㏠ㆠㆿၽڲ䘕⪼Ⅱ㐀वѺ㒛ᰶ䭽喑ज ܧ⣝ౕ 3315 cm 喑䄡ᬻ LA হ Zein ͸䬡ᒏ᜽⅏䩛 [17] ȡ
–1
㘪ᄩ㜡 LA क़䛼䊲䓴㐀वѺ◦ᬣ喑̺㘪̻⪼Ⅱࡧഌ Zein ౕ 1527 হ 1657 cm ั⮱॥ᩣምܳݘᄦᏁ㯸⮪
–1
㐀व喑ϻ㔹ᄩ㜡᝭䃎ツ⮱࠲ᄮ⢴হ䒪㢜䛼ۼᄾ [12] ȡ 䉕ܳၽ͚䚝㘧Ĕፓ C—H ᑜᰟᡜߕহ䚝㘧ēፓ C==O
ധλ̷䔝჋侹㐀᳉喑㔰㭾ݝ჋䭲㷲䒪䛼䬛䷅喑 ѥ㑖ᡜߕ [18] 喑ౕ LA-Zein ͚喑䔆͑ั॥ᩣምܳݘͧ
ౕ m(Zein)ńm(LA)=25ń1 ̸喑LA-Zein-MC ㏠ㆠㆿ 1530 হ 1656 cm 喑䔆ज㘪᭜఍ͧ䲆⩢॥ᑂ [19] ȡLA
–1
ၽㆿᒱȠPDI Ⱕᄦ䒰ᄼ喑Zeta ⩢Ѻͧ–32.1 mV喑࠲ ౕ 938 cm ั⮱ OÿH 䩛⮱ѥ㑖ᡜߕ॥ᩣም⊵๞喑
–1
ᄮ⢴ͧ 56.17%喑䒪㢜䛼ͧ 0.56%ȡ఍ₑ喑ः m(Zein)ń ࣌఍ज㘪 LA হ Zein ͸䬡ࣾ⩌γ⪼ⅡⰥο҉⩕喑LA
m(LA)=25ń1 Ჱᐧ LA-Zein-MC ㏠ㆠㆿၽ䓽䒪Ҁ㈨ 㷘࠲㸦ౕ㏠ㆠㆿၽᵥᓰ喑ᄩ㜡॥ᩣም⊵๞ [17] ȡ
䔈㵹ऻ㐚ⵁ⾣喑ऻ㐚჋侹౴䛴⩕ LA-Zein-MC ㏠ㆠㆿ LA-Zein-MC ㏠ㆠㆿၽౕ 1038 cm ัܧ⣝᫝⮱॥ᩣ
–1
ၽ M9 䔈㵹≸Ⴧȡ ም喑䔆᭜ MC ͚ CÿOÿC 䩛⮱ѥ㑖ᡜߕ➦ᒮም [20] ȡ
2.4 ㏠ㆠㆿၽᒏᔮܳᲽ HU ぶ [21] ౕࢂႮ䚥҉ͧ๖♣ϑ㖁ݯݣิ⾧ᓰ⢶ㆠ㯸
ఫ 6 ͧ㏠ㆠㆿၽۤۨ᎟✒ऻ⮱ SEM ఫȡ ⮪㏠ㆠㆿၽ⮱ⵁ⾣͚喑䕇䓴 FTIR ٶ䅞ࣾ⣝γА㶕

༉叱㉍⮱㟠仆⣜॥ᩣም⼨ߕ喑༉叱㉍হ Zein ܳၽ䬡
Όႅౕ⪼ⅡᕔⰥο҉⩕ȡ

aÿZein ㏠ㆠㆿၽ喠bÿLA-Zein ㏠ㆠㆿၽ喠c~dÿLA-Zein-MC

㏠ㆠㆿၽ喍M9喎 ఫ 7 LA喍a喎ȠZein喍b喎ȠLA-Zein ㏠ㆠㆿၽ喍c喎Ƞ
ఫ 6 ̺ह㏠ㆠㆿၽ⮱ SEM ఫ LA-Zein-MC ㏠ㆠㆿၽ喍d喎⮱ FTIR 䅞ఫ
Fig. 6 SEM images of different nanoparticles Fig. 7 FTIR spectra of LA (a), Zein (b), LA-Zein nanoparticles
(c), LA-Zein-MC nanoparticles (d)
ϻఫ 6 जВⰸܧ喑Zein ㏠ㆠㆿၽᅧᄥౕ܍࡮㏠
ㆠȡLA-Zein ㏠ㆠㆿၽ⮱ㆿᒱ㺮⼺๔λ Zein ㏠ㆠㆿ 2.6 XRD ܳᲽ
ၽȡ́⇎ᰶԛ亝䓴⮱ Zein ㏠ㆠㆿၽ౴ᰶ̺ह⼸Ꮣ⮱ ͧ䔈̭ₒ侹䃮 LA হ㯸⮪㏠ㆠㆿၽ͸䬡⮱Ⱕο
叼䔋喑䔆᭜఍ͧ喑Zein ㏠ㆠㆿၽౕۤۨ᎟✒䓴⼸͚ ҉⩕喑Ҭ⩕ XRD ᄦ LA হ LA-Zein-MC ㏠ㆠㆿၽ䔈
Ⅱܳࡴࡻ喑䕍᜽㏠ㆠㆿၽ叼䔋ȡ㔹 MC ԛ亝䓴ऻ⮱ 㵹ܳᲽ喑㐀᳉ຯఫ 8 ᝭⹧ȡ