Page 194 - 《精细化工》2023年第4期
P. 194
g880g ㏳ࡃጒ FINE CHEMICALS す 40 ࢤ
LA-Zein ㏠ㆠㆿၽ⮱ݣิ喟ᠶҀ⼜℁ 1ń5 ⮱℁ ःᄾ䛼ㆶ᱘叼䭱λᄩ⩢㘣̷喑䛾ऻౕ SEM ̸㻯
Ҹ⩕㵂ߕ∢ᄳ 10 mL ⏣⋟ B3 㑀ᚏܳ᪐㜠 50 mL ࣨ ᄌ喑倅ⱌ⾧ᐼ喑3.0 kV ߍ䕌⩢ࢸȡFTIR ≸䄂喟LAȠ
⻨ၽⅡ͚喑ₑᬣ LA-Zein 䕇䓴ࣺ⏣ݯ↶⋭ᒏ㏠ㆠ ZeinȠLA-Zein ㏠ㆠㆿၽȠLA-Zein-MC ㏠ㆠㆿၽ̻
ㆿၽܳ᪐⋟喑ܳ᪐⮱हᬣВ 800 r/min ⮱䕌⢴ⷮ߈ᤲ KBr ᠶ 1ń100 ⮱䉕䛼℁⌤व喑⩕ⵁ䧢ⵁ⸕࠭喑⩕
៹喑ߍ᫆㐀ऻ喑㐔㐚ᤲ៹ 30 min喑Ꭰ㶎ऻݣᓄ ࢸ❴ᱧࢸ❴⟣喑䛴⩕ֲ䛹णअᢏ㏏ใٶ䅞З≸䄂喑
–1
LA-Zein ㏠ㆠܳ᪐⋟喑ౕ 35 Ď̸⩕䒙㧥ࣾЗ䮑ࣨ ∏㠰డ 4000~500 cm 喑ម⁎ 64 ⁎喑ܳ䓕⢴
–1
Ά䚴ȡ3000 r/min ⻨ᓰ 10 min ऻः̷⌲⋟ᩫ㒛ݝᎠ 4 cm ȡDSC ≸䄂喟ݖ⩕ጛម䛼☚З≸Ⴧ㏠ㆠ
Წ͚喑–50 Ďۤۨ✒ 24 h ऻᓄݝధҀ LA-Zein ㏠ ㆿၽ⮱☚߈႓➦ᕔ喑⼝ः 5 mg ᵤ৮ᩫڒݝᴴ۳
ㆠㆿၽ喑䃝ͧ M11ȡ 䨊⯿喑䛴⩕⾧䨊Ⰵᵎ۳ധ㏬喑ᎣᵎₐЗக࣯喑≸
Zein-MC ㏠ㆠㆿၽ⮱ݣิ喟ᠶҀ⼜℁ 1ń5 ⮱℁ 䄂ᬣ䕇ڒ N 2 Ԋ៑喑≮䕌ͧ 20 mL/min喑ម⍖Ꮣ㠰
Ҹ⩕㵂ߕ∢ᄳ 10 mL ⏣⋟ B5 ܳݘ㑀ᚏܳ᪐㜠 50 mL డϻბ⍖~200 Ď喑ߍ☚䕌⢴ͧ 10 Ď/minȡXRD ≸
⏣⋟ A1ȠA2ȠA3ȠA4ȠA5ȠA6 ͚喑ₑᬣ LA-Zein 䄂喟䛴⩕ X ᄱ㏬㵺ᄱЗᄦ LAȠ㏠ㆠㆿၽ䔈㵹≸Ⴧ喑
হ MC 䕇䓴ڞ↶ᒏ㏠ㆠㆿၽܳ᪐⋟喑ܳ᪐⮱हᬣ ≸䄂⩢ࢸͧ 45 kV喑⩢≮ͧ 200 mA喑ម㻿Ꮣ喍2ș喎
В 800 r/min ⮱䕌⢴ⷮ߈ᤲ៹喑ߍ᫆㐀ऻ喑㐔㐚ᤲ 㠰డͧ 5°~50°喑ម䕌⢴䃫㒛ͧ 4 (°)/minȡ
៹ 30 min喑Ꭰ㶎ऻݣᓄ LA-Zein-MC ㏠ㆠܳ᪐⋟喑 1.3.2 ᕔ㘪≸䄂
ౕ 35 Ď̸⩕䒙㧥ࣾЗ䮑ࣨΆ䚴ȡ3000 r/min ⻨ᓰ 1.3.2.1 LA ࠲ᄮ⢴⮱≸Ⴧ
10 min ऻः̷⌲⋟ᩫ㒛ݝᎠᲬ͚喑–50 Ďۤۨ✒ 䛴⩕倅᩵⋟Ⱕ㞟䅞Зᄦ LA क़䛼䔈㵹ᷭ≸喑䔈
24 h ऻᓄݝధҀ Zein-MC ㏠ㆠㆿၽ喑ܳݘ䃝ͧ M1Ƞ ᵤ䛼ͧ 20 ȝL喑ᴞ⍖ͧ 30 Ď喑≮䕌ͧ 1 mL/min喑
M2ȠM3ȠM4ȠM5ȠM6ȡ C18 㞟䅞ᴞ喟250 mm × 4.6 mm喑᫆ㆿᒱ 4 ȝm喑
ᠶҀ⼜℁ 1ń5 ⮱℁Ҹ⩕㵂ߕ∢ᄳ 10 mL ⏣⋟ ᷭ≸∏䪬 210 nm喑≮ߕⰥͧΆ㙵হⅡҀ⼜℁ͧ 4ń6
B1ȠB2ȠB3ȠB4 ܳݘ㑀ᚏܳ᪐㜠 50 mL ⏣⋟ A4 ⮱⌤व⋟喑≮ߕⰥ⩕⸤䚥䄰㜠 pH ͧ 3.5ȡ䛴⩕ใᴴ
͚喑ₑᬣ LA-Zein হ MC 䕇䓴ڞ↶ᒏ㏠ㆠㆿၽܳ ∂≸Ⴧ喑В LA 䉕䛼⊀Ꮣͧὗ౽ᴴ喍x喑g/L喎喑ም䲏
᪐⋟喑ܳ᪐⮱हᬣВ 800 r/min ⮱䕌⢴ⷮ߈ᤲ៹喑ߍ ⼜ͧ㏢౽ᴴ喍y喎喑㐅ݣ⮱ᴴ۳ᰟ㏬⼸ຯᐼ喍1喎喟
2
᫆㐀ऻ 喑㐔㐚ᤲ ៹ 30 min 喑Ꭰ㶎ऻ ݣᓄ y=8.7906x–0.1828喑R =0.9996 喍1喎
LA-Zein-MC ㏠ㆠㆿၽܳ᪐⋟喑ܳݘ䃝ͧ M7ȠM8Ƞ 仃ٵ喑⼝ः 100 mg LA-Zein-MC ㏠ㆠㆿၽλ⻨
M9ȠM10 ㏠ㆠㆿၽܳ᪐⋟喑ౕ 35 Ď̸⩕䒙㧥ࣾ ᓰノ͚喑♣ऻᄳڣ̻ 8 mL ᬍⅡΆ䚴⌤व喑⋎ 60 s喑
З䮑ࣨΆ䚴ȡ3000 r/min ⻨ᓰ 10 min ऻः̷⌲⋟ᩫ㒛 3000 r/min ̸⻨ᓰ 10 min ऻ喑ः̷⌲⋟䔯ᒀ⼭䛷ऻ喑
ݝᎠᲬ͚喑 –50 Ď ۤۨ ✒ 24 h ऻᓄݝధҀ ⩕倅᩵⋟Ⱕ㞟䅞Зౕ 210 nm ั≸ڣም䲏⼜喑⩞ᐼ
LA-Zein-MC ㏠ㆠㆿၽ喑ܳݘ䃝ͧ M7ȠM8ȠM9ȠM10ȡ 喍1喎䃎ツ⍥⻨ LA ⮱䉕䛼⊀Ꮣ喠䛺ฺ 3 ⁎ȡᄳ 100 mg
M9 হ 8 mL ᬍⅡΆ䚴ᩫڒλ⻨ᓰノ͚⌤व喑♣ऻ
㶕 1 ̺ह䉕䛼⊀ᏓУ̸ LA-Zein-MC ㏠ㆠㆿၽ⮱ݣิ
Table 1 LA-Zein-MC nanoparticles prepared under different ⋎ 60 s喑ბ⍖̸ 500 W 䊲ฝ 15 min喑ₑᬣ⻨ᓰノ̸
mass concentrations 䘕ܳ᭜⮪㞟↶⋭ȡ9000 r/min ̸⻨ᓰ 10 min ऻ喑ः
㏠ㆠㆿၽ LA/mg Zein/g MC/g ⏣⋟㏱व m(Zein)ńm(MC) ̷⌲⋟㏼䔯ᒀ⼭䛷ऻ喑⩕倅᩵⋟Ⱕ㞟䅞Зౕ 210 nm
M1 0 0.3 0.18 A1+B5 1ń0.6 ั≸ڣም䲏⼜喑⩞ᐼ喍1喎䃎ツ LA ᕨ⮱䉕䛼⊀Ꮣ喑
M2 0 0.3 0.36 A2+B5 1ń1.2 䛺ฺ 3 ⁎ȡᵦᢛᐼ喍2喎হ喍3喎ܳݘ䃎ツ LA ⮱࠲
M3 0 0.3 0.54 A3+B5 1ń1.8 ᄮ⢴喍%喎হ䒪㢜䛼喟
M4 0 0.3 0.72 A4+B5 1ń2.4 U – U
वሱ⦷ / % 2 1 u 100 喍2喎
M5 0 0.3 0.90 A5+B5 1ń3.0 U
2
M6 0 0.3 1.08 A6+B5 1ń3.6
ᐼ͚喟ȡ 1 ͧ⍥⻨ LA ⮱䉕䛼⊀Ꮣ喑g/L喠ȡ 2 ͧ LA ⮱
M7 60 0.3 0.72 B1+A4 1ń2.4
ᕨ⮱䉕䛼⊀Ꮣ喑g/Lȡ
M8 30 0.3 0.72 B2+A4 1ń2.4 m – m
M9 12 0.3 0.72 B3+A4 1ń2.4 L / %= 2 1 u 100 喍3喎
m
M10 6 0.3 0.72 B4+A4 1ń2.4
ᐼ͚喟L ͧ䒪㢜䛼喑%喠m 1 ͧ⍥⻨ LA ⮱䉕䛼喑mg喠
M11 12 0.3 0 B3+ࣨ⻨ၽⅡ
m 2 ͧ LA ⮱ᕨ䉕䛼喑mg喠m ͧ㏠ㆠㆿၽ䉕䛼喑mgȡ
1.3 㐀Ჱ㶕ᒮহᕔ㘪≸䄂 1.3.2.2 pH ⽠Ⴧᕔ⮱≸䄂
1.3.1 㐀Ჱ㶕ᒮ ᄳᠶ⚔ 1.2.2 㞯䙺ݣ⮱ M9 ㏠ㆠㆿၽܳ᪐⋟⩕
SEM ≸䄂喟ᄳۤۨ✒⮱㏠ㆠㆿၽ⩕℈㏳॥ノ 10 mol/L ⮱ᴍῙ䚥-⸤䚥⯽㑀۟⋟䄰㞯 pH喑Ҭ㏠ㆠ
