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第 35 卷第 10 期 精 细 化 工 Vol.35, No.10
2018 年 10 月 FINE CHEMICALS Oct. 2018

医药与日化原料
细菌纤维素/聚乳酸复合膜制备及性能

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张 雯 ，王学川 ，余婷婷 ，刘艺秀 ，彭晓雪
（1. 陕西科技大学 食品与生物工程学院，陕西 西安 710021；2. 陕西科技大学 轻工科学与工程学院，
陕西 西安 710021）
摘要：以聚乳酸（PLA）为原料，利用细菌纤维素（BC）生产菌株发酵制得 BC/ PLA 复合膜。通过对 BC/PLA
复合膜制备过程中发酵时间、纺膜速率、PLA 溶液用量等因素的考察，以 BC/PLA 复合膜载药率为指标，进行
了 BC/PLA 复合膜制备工艺的优化；利用 FTIR、TG、拉力实验、XRD 及 SEM 对 BC、PLA 及 BC/PLA 复合膜
化学基团、热性能、力学性能、结晶度及表面形貌进行了分析；对 BC/PLA 复合膜载药及释药过程进行了研究。
结果表明，PLA 溶液用量对 BC/PLA 复合膜载药率影响较小，BC/PLA 复合膜最优制备工艺为：纺膜速率 0.15 mm/s，
发酵时间 36 h，所制备 BC/PLA 复合膜在 15 mg/L 双氯芬酸钾药液中最大载药率为 2.51 mg/g。FTIR、TG、拉
力实验、XRD 及 SEM 结果表明，BC 与 PLA 可以成功复合，从而改善 PLA 的热性能及力学性能，所制备 BC/PLA
复合膜具有三维网状多孔结构。载药 BC/PLA 复合膜药物释放过程符合一级释放动力学模型。
关键词：细菌纤维素；聚乳酸；复合膜；载释药；医药与日化原料
中图分类号：TB332 文献标识码：A 文章编号：1003-5214 (2018) 10-1695-07

Preparation and Properties of Bacterial Cellulose/Poly
Lactic Acid Composite Films

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ZHANG Wen , WANG Xue-chuan , YU Ting-ting , LIU Yi-xiu , PENG Xiao-xue
（1. School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi' an 710021, Shaanxi,
China; 2. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology,
Xi'an 710021, Shaanxi, China）
Abstract: Bacterial cellulose (BC)/polylactic acid (PLA) composite films were prepared. The effects of
fermentation time, electrospinning speed and volume of PLA solution on the drug-loading rate of BC/PLA
composite film were studied. The chemical groups, thermal properties, mechanical properties, crystallinity
and surface morphology of the BC/PLA composite film were analyzed by FTIR, TG, tensile test, XRD and
SEM. The drug loading and releasing process of BC/PLA composite film was investigated. The results
indicated that volume of PLA solution showed a small effect on the drug-loading rate of BC/PLA composite
film. The optimal preparation process of BC/PLA composite film was determined as follows: electrospinning
speed 0.15 mm/s, fermentation time 36 h. Under these conditions, the maximum drug-loading rate of
BC/PLA composite film could reach to 2.51 mg /g in 15 mg/L potassium diclofenate solution. The results
showed that BC and PLA could be combined successfully, which improved the thermal properties and
mechanical properties of PLA. And the composite film had a three-dimensional porous net-work structure.
The drug-releasing process of film followed the first-order release dynamics model.
Key words: bacterial cellulose; polylactic acid; composite film; drug loading and releasing; drug and
cosmetic materials
Foundation items: Agricultural Project of Department of Science and Technology of Shaanxi Province
(2016NY-156); Science and Technology Plan of Weiyang District, Xi'an City of China (201606)

收稿日期：2018-05-25; 定用日期：2018-09-17; DOI: 10.13550/j.jxhg.20180373
基金项目：陕西省科技厅农业攻关项目（2016NY-156）；陕西省西安市未央区科技计划项目（201606）
作者简介：张 雯（1982—），女，博士，副教授，E-mail：zwen102@163.com。联系人：王学川（1963—），男，教授，博士生导师，
15802958501@163.com。