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·498·                             精细化工   FINE CHEMICALS                                  第 36 卷

            3    结论                                            [6]   Wei  Q  Y,  Jiang  H,  Zhang  J  X,  et al.  Synthesis  of
                                                                   N-hydroxycinnamoylamino acid ester analogues and their free radical
                 合成了Ⅲa、Ⅲb、Ⅲc、Ⅲd 4 种咖啡酰氨基酸乙                         scavenging  and  antioxidative  activities[J].  Medicinal  Chemistry
            酯。实验结果显示,4 种咖啡酸酰胺类衍生物功效性                               Research, 2012, 21(8): 1905-1911.
                                                               [7]   Rajan  P,  Vedernikova  I,  Cos  P,  et al.  Synthesis  and  evaluation  of
            均有提高,均呈现较好的抑制 DPPH 自由基、羟基
                                                                   caffeic  acid  amides  as  antioxidants[J].  Bioorganic  &  Medicinal
            自由基活性的效果,且Ⅲa 清除 DPPH 自由基能力
                                                                   Chemistry Letters, 2001, 11(2): 215-217.
            最强,其 IC 50 为(11.23±0.24)µmol/L;Ⅲc 清除羟              [8]   Yoo Y J, Nam D H, Jung S Y, et al. Synthesis of cinnamoylketoamides
            基自由基能力最强,其 IC 50 为(0.24±0.002) mmol/L。                 as hybrid structures of antioxidants and calpain inhibitors[J]. Bioorganic
            4 种合成产物抗氧化性存在差异,这主要是由于氨                                & Medicinal Chemistry Letters, 2011, 21(10): 2850-2854.
                                                               [9]   Karau A, Grayson I. Amino acids in human and animal nutrition[J].
            基酸的结构不同而导致的差异性。4 种咖啡酰氨基
                                                                   Advances in Biochemical Engineering, 2014, 143: 189-228.
            酸乙酯类衍生物中的 3 种相对于咖啡酸单体,对红
                                                               [10]  Furneri P M, Piperno A, Sajia A, et al. Antimycoplasmal activity of
            细胞膜具有更弱的刺激性,表明与氨基酸乙酯结合                                 hydroxytyrosol[J].  Antimicrobial  Agents  &  Chemotherapy,  2004,
            后的咖啡酸具有更高的安全性。                                         48(12): 4892-4894.
                 在后续研究中,可以用咖啡酸与更多不同种类                          [11]  Noh  J  M,  Kwak  S  Y,  Seo  H  S,  et al.  Kojic  acid-amino  acid
            的氨基酸结合进行生物活性比较,揭示相关的分子                                 conjugates  as  tyrosinase  inhibitors[J].  Bioorganic  &  Medicinal
                                                                   Chemistry Letters, 2009, 19(19): 5586-5589.
            机理,阐明生物活性与结构之间的联系,在原料安
                                                               [12]  Anselmi C, Centini M, Andreassi M, et al. Conformational analysis:
            全性方面可以增加鸡胚绒毛尿囊膜实验进行多方面                                 a tool for the elucidation of the antioxidant properties of ferulic acid
            论证来证明原料的安全性。                                           derivatives  in  membrane  models[J].  Journal  of  Pharmaceutical  &
                                                                   Biomedical Analysis, 2004, 35(5): 1241-1249.
            参考文献:                                              [13]  Boath  A  S,  Stewart  D,  Mcdougall  G  J.  Berry  components  inhibit
            [1]   Silva T, Oliveira C, Borges F. Caffeic acid derivatives, analogs and   α-glucosidase in vitro: synergies between acarbose and polyphenols
                 applications: a patent review (2009 -2013)[J]. Journal of Agricultural   from black currant and rowanberry[J]. Food Chemistry, 2012, 135(3):
                 & Food Chemistry, 2014, 52(9): 1257-1270.         929-936.
            [2]   Chochkova M, Stoykova B, Ivanova G, et al. N-hydroxycinnamoyl   [14]  Fan Q, Jiang H, Yuan E D, et al. Tyrosinase inhibitory effects and
                 amides  of  fluorinated  amino  acids:  synthesis,  anti-tyrosinase  and   antioxidative activities of novel cinnamoyl amides with amino acid
                 dpph scavenging activities[J]. Journal of Fluorine Chemistry, 2013,   ester moiety[J]. Food Chemistry, 2012, 134(2): 1081-1087.
                 156(12): 203-208.                             [15]  Treml  J,  Šmejkal  K.  Flavonoids  as  potent  scavengers  of  hydroxyl
            [3]   Mattila P, Hellstr M J, Trrnen R. Phenolic acids in berries, fruits, and   radicals[J]. Comprehensive Reviews in Food Science & Food Safety,
                 beverages[J]. Journal  of  Agricultural  &  Food  Chemistry,  2006,   2016, 15(4): 720-738.
                 54(19): 7193-7199.                            [16]  Zhang Wengai (张文改), Yang Xingfen (杨杏芬), Yang Ying (杨颖),
            [4]   Sun  Y,  Yu  Y  Y,  Cao  S  W.  Antioxidant  capacity  of  caffeicacid,   et al.  Preliminary  study  on  red  blood  cell  haemolysis  assay  as  an
                 phloretin  and  glutathione  mixtures  and  formula  optimization[J].   alternative method for eye irritation test[J]. Chin Prev Med (中国预
                 Asian Journal of Chemistry, 2013, 25(7): 3971-3978.     防医学杂志), 2010, 11(6): 544-547.
            [5]   Jiang  R  W, Lau K M,  Hon  P  M,  et al.  Chemistry  and  biological   [17]  Wang  Yufeng  (王羽峰),  Cheng  Jun  (成军).  Effect  of  leucine  on
                 activities  of  caffeic  acid  derivatives  from  salvia  miltiorrhiza[J].   membrane  potential  of  sputum  oocytes  and  its  mechanism[J].
                 Current Medicinal Chemistry, 2005, 12(2): 237-246.     Heilongjiang Medical Science (黑龙江医药科学), 1989, 12(1): 1-4.
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