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·2232· 精细化工 FINE CHEMICALS 第 38 卷

hypochlorite in the mitochondria of living cells[J]. Biosensors &
Bioelectronics, 2018, 107: 218-223.
[6] GAO P, PAN W, LI N, et al. Fluorescent probes for organelle-targeted
bioactive species imaging[J]. Chemical Science, 2019, 10(24):
6035-6071.
[7] ATCHUDAN R, EDISON T N J I, ASEER J R, et al. Highly
fluorescent nitrogen-doped carbon dots derived from Phyllanthus
acidus utilized as a fluorescent probe for label-free selective
3+
detection of Fe ions, live cell imaging and fluorescent ink[J].
Biosensors & Bioelectronics, 2018, 99: 303-311.
[8] GAO M, YU F B, LYU C J, et al. Fluorescent chemical probes for
accurate tumor diagnosis and targeting therapy[J]. Chemical Society

Reviews, 2017, 46(8): 2237-2271.
图 12 Q p 对粒子尺寸和环状流直径的影响 [9] PU K Y, CHATTOPADHYAY N, RAO J H. Recent advances of
Fig. 12 Effect of Q p on particle size and annular flow semiconducting polymer nanoparticles in vivo molecular imaging[J].
diameter Journal of Controlled Release, 2016, 240: 312-322.

[10] TUNCEL D, DEMIR H V. Conjugated polymer nanoparticles[J].
3 结论 Nanoscale, 2010, 2(4): 484-494.
[11] CHAN Y H, WU P J. Semiconducting polymer nanoparticles as
fluorescent probes for biological imaging and sensing[J]. Particle &
通过微流体技术制备了荧光 PFBT 聚合物纳米 Particle Systems Characterization, 2015, 32(1): 11-28.
粒子。通过改变操作条件可对纳米粒子的尺寸进行 [12] KHAN I U, SERRA C A, ANTON N, et al. Microfluidics: A focus on
improved cancer targeted drug delivery systems[J]. Journal of
调控。适当降低 PFBT 溶液浓度有利于减小纳米粒
Controlled Release, 2013, 172(3): 1065-1074.
子的平均粒径。反应器内 PFBT 溶液与水混合得越 [13] BABY T, LIU Y, MIDDELBERG A P J, et al. Fundamental studies
快，纳米粒子平均粒径越小。当 PFBT 溶液质量浓 on throughput capacities of hydrodynamic flow-focusing microfluidics
for producing monodisperse polymer nanoparticles[J]. Chemical
度为 50 mg/L、Q p 为 2 μL/min、Q m 为 3 μL/min、Q w Engineering Science, 2017, 169: 128-139.
为 1500 μL/min 时，制得平均粒径低至 13 nm 的纳 [14] ABALDE-CELA S, TALADRIZ-BLANCO P, DE OLICEIRA M,
米粒子。利用七孔毛细管制备的同轴毛细管阵列微 et al. Droplet microfluidics for the highly controlled synthesis of
branched gold nanoparticles[J]. Scientific Reports, 2018, 8: 1-6.
反应器在 PFBT 溶液和反溶剂之间加入了中间层溶 [15] MAEKI M, KIMURA N, SATO Y, et al. Advances in microfluidics
剂，改变了两者的混合方式，解决了传统微流体注射 for lipid nanoparticles and extracellular vesicles and applications in
drug delivery systems[J]. Advanced Drug Delivery Reviews, 2018,
纳米沉淀法在制备纳米粒子时混合入口处纳米粒子的 128: 84-100.
聚集沉淀问题，为微反应器连续制备可控纳米粒子提 [16] MA X D, OZLISELI E, ZHANG Y Z, et al. Fabrication of redox-responsive
供了新方法。 doxorubicin and paclitaxel prodrug nanoparticles with microfluidics
for selective cancer therapy[J]. Biomaterials Science, 2019, 7(2): 634-644.
参考文献： [17] WANG Z, GUO B, MIDDHA E, et al. Microfluidics-prepared uniform
conjugated polymer nanoparticles for photo-triggered immune
[1] WU X M, LI Y A, YANG S X, et al. A multiple-detection-point microenvironment modulation and cancer therapy[J]. ACS Applied
fluorescent probe for the rapid detection of mercury(Ⅱ), hydrazine Materials & Interfaces, 2019, 11(12): 11167-11176.
and hydrogen sulphide[J]. Dyes and Pigments, 2019, 174: 108056. [18] KONG L L, CHEN R, WANG X Z, et al. Controlled co-precipitation
[2] WU C F, CHIU D T. Highly fluorescent semiconducting polymer of biocompatible colorant-loaded nanoparticles by microfluidics for
dots for biology and medicine[J]. Angewandte Chemie International natural color drinks[J]. Lab on a Chip, 2019, 19(12): 2089-2095.
Edition, 2012, 52(11): 3086-3109. [19] CAPRETTO L, CARUGO D, MAZZITELLI S, et al. Microfluidic
[3] PENG H S, CHIU D T. Soft fluorescent nanomaterials for biological and lab-on-a-chip preparation routes for organic nanoparticles and
and biomedical imaging[J]. Chemical Society Reviews, 2015, 44(14): vesicular systems for nanomedicine applications[J]. Advanced Drug
4699-4722. Delivery Reviews, 2013, 65(11/12): 1496-1532.
[4] DUAN C, WON M, VERWILST P, et al. In vivo imaging of [20] YANG Z (杨洲). Preparation of fluorescent polymer nanoparticles in
endogenously produced HClO in zebrafish and mice using a bright, microreactor[D]. Dalian: Dalian University of Technology (大连理
photostable ratiometric fluorescent probe[J]. Analytical Chemistry, 工大学), 2020.
2019, 91(6): 4172-4178. [21] YANG Z, LIU D S. Microfluidics-based preparation of fluorescent
[5] ZHU B C, WU L, ZHANG M, et al. A highly specific and polymer dots[J]. Fine Chemicals ( 精细化 工 ), 2020, 37(10):
ultrasensitive near-infrared fluorescent probe for imaging basal 2021-2026.