Page 81 - 《精细化工》2021年第11期

第 38 卷第 11 期 精 细 化 工 Vol.38, No.11
2021 年 11 月 FINE CHEMICALS Nov. 2021

功能材料
毛细管阵列微反应器制备荧光聚合物纳米粒子

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白 瑞，刘定胜
（大连理工大学 化工学院，辽宁 大连 116024）

摘要：设计并制作了同轴毛细管阵列微反应器，以聚(9,9-二辛基芴-共-苯并噻二唑)（PFBT）为原料、四氢呋喃
为溶剂、去离子水为反溶剂、聚苯乙烯-马来酸酐共聚物为稳定剂，采用纳米沉淀法制备了聚合物荧光纳米粒子。
用动态光散射技术（DLS）对荧光聚合物纳米粒子的结构进行了表征。结果表明，同轴毛细管阵列微反应器中
间层溶剂的存在改变了 PFBT 溶液与反溶剂的混合方式，克服了微流体注射纳米沉淀法中注射管口的产物沉淀
堵塞问题。在 PFBT 质量浓度高达 500 mg/L 时，反应器仍可长时间持续运行。同时，聚合物纳米粒子的粒径可
通过改变 PFBT 溶液质量浓度、溶剂和反溶剂的流量比等条件来精确调控。当 PFBT 溶液质量浓度为 50 mg/L、
去离子水与 PFBT 溶液流量比为 750 时，制备的聚合物纳米粒子尺寸可降至 13 nm。该微反应器实现了聚合物纳
米粒子的长时间连续可控制备。
关键词：同轴微反应器；毛细管阵列；纳米沉淀法；荧光聚合物；纳米粒子
中图分类号：TQ317；TB383 文献标识码：A 文章编号：1003-5214 (2021) 11-2227-06

Preparation of fluorescent polymer nanoparticles
based on capillary array microreactor

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BAI Rui, LIU Dingsheng
（School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China）

Abstract: A coaxial capillary array microreactor was designed and constructed to prepare fluorescent
polymer nanoparticles by nanoprecipitation method using poly(9,9-dioctylfluorene-co-benzothiadiazole)
(PFBT) was used as polymer, tetrahydrofuran as solvent, deionized water as anti-solvent and
polystyrene-maleic anhydride copolymer as stabilizer. The prepared fluorescent polymer nanoparticles were
characterized by dynamic light scattering (DLS). The results showed that the accumulation and blockage of
products were avoided at the tip of the injection nozzle in the microreactor due to the middle solvent stream
which changed the mixing process between PFBT solution and anti-solvent. The microreactor kept on
running well for a long time even at the high concentration of PFBT solution of 500 mg/L. Meanwhile, the
size of the nanoparticles could be adjusted precisely by varying the mass concentration of PFBT solution
and the flow ratio between solvent and anti-solvent. The diameter of the prepared nanoparticles could be
reduced to 13 nm under the conditions of mass concentration of PFBT solution 50 mg/L and flow ratio of
deionized water to PFBT solution 750. The microreactor could realize the long-term continuous and
controllable preparation of polymer nanoparticles.
Key words: coaxial microreactor; capillary array; nanoprecipitation method; fluorescent polymer;
nanoparticles

荧光技术在生命科学和医学领域占据着重要地 中，荧光通常应用于分子成像、细胞追踪和生物传
位，随着新型荧光标记和成像设备的进步，荧光技 感等方面 [4-8] 。在种类繁多的荧光纳米材料中，荧光
术得到越来越多的重视 [1-3] 。在常规的生物学应用 聚合物纳米粒子（FPN）由于其相对较高的吸光系

收稿日期：2021-04-19; 定用日期：2021-06-04; DOI: 10.13550/j.jxhg.20210408
基金项目：中央高校基本科研业务费专项基金〔DUT16RC(3)001，DUT19LAB30〕
作者简介：白 瑞（1996—），男，硕士生。联系人：刘定胜（1979—），男，副教授，E-mail：dsliu@dlut.edu.cn。