Page 151 - 《精细化工》2022年第6期

第 6 期 雷高乙，等: 酶促酯化拆分-化学消旋串联法制备(S)-布洛芬 ·1217·

时，e.e.值接近于 0，说明(R)-布洛芬已经完全消旋。 3 结论

在环己烷中，利用 CALB 的对映选择性酯化反
应拆分(±)-布洛芬，48 h 拆分效果达到最好，e.e.值
为 100%，(S)-布洛芬收率为 56%；然后，将(S)-布
洛芬分离，将生成的(R)-布洛芬异丁酯水解为(R)-布
洛芬；再以二甲基亚砜为反应介质，利用二异丙基
氨基锂催化(R)-布洛芬的外消旋反应，2 h 消旋完全，
e.e.值为 0；最后，对选择性酶促酯化拆分反应进行
了放大，放大 50 倍至克级，e.e.值仍能达到 100%。

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