Page 169 - 《精细化工》2022年第7期

第 7 期 杨佳慧，等: 包载槲皮素 P/O/W 多重 Pickering 乳液的制备及表征 ·1455·

此外体系组成中含有的内醇相（甘油以及一缩二丙 液制备的影响，得到 P/O/W 多重 Pickering 乳液最佳
二醇）以及不饱和脂肪酸（月见草油）等也可以增强 制备条件为：内醇相〔m(甘油)∶m(一缩二丙二醇)=
角质层脂质流动性，进而促进槲皮素的经皮输送 [32] 。 6∶4〕质量分数为 20%、疏水 SiO 2 质量分数为 3%、
总之，与槲皮素水分散液相比，P/O/W 多重乳液对 m(水相)∶m(P/O 初乳)=5∶5、亲水 SiO 2 质量分数为
槲皮素包载后可显著提高槲皮素的溶解度和透皮性 2%。
能，具有一定的皮肤靶向作用。 （2）采用 P/O/W 多重 Pickering 乳液对油水两
难溶性活性物槲皮素进行包载，有效提高了槲皮素

的溶解度及透皮性能。
（3）在之后的研究中可将该体系用于其他油水
两难溶性活性物的包载，考察该体系的普适性。

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