Page 169 - 《精细化工》2022年第7期
P. 169

第 7 期                 杨佳慧,等:  包载槲皮素 P/O/W 多重 Pickering 乳液的制备及表征                         ·1455·


            此外体系组成中含有的内醇相(甘油以及一缩二丙                             液制备的影响,得到 P/O/W 多重 Pickering 乳液最佳
            二醇)以及不饱和脂肪酸(月见草油)等也可以增强                            制备条件为:内醇相〔m(甘油)∶m(一缩二丙二醇)=
            角质层脂质流动性,进而促进槲皮素的经皮输送                      [32] 。  6∶4〕质量分数为 20%、疏水 SiO 2 质量分数为 3%、
            总之,与槲皮素水分散液相比,P/O/W 多重乳液对                          m(水相)∶m(P/O 初乳)=5∶5、亲水 SiO 2 质量分数为
            槲皮素包载后可显著提高槲皮素的溶解度和透皮性                             2%。
            能,具有一定的皮肤靶向作用。                                        (2)采用 P/O/W 多重 Pickering 乳液对油水两
                                                               难溶性活性物槲皮素进行包载,有效提高了槲皮素

                                                               的溶解度及透皮性能。
                                                                  (3)在之后的研究中可将该体系用于其他油水
                                                               两难溶性活性物的包载,考察该体系的普适性。

                                                               参考文献:
                                                               [1]   BOOTS A W, HAENEN G R, BAST A. Health effects of quercetin:
                                                                   From antioxidant to nutraceutical[J]. European Journal of Pharmacology,
                                                                   2008, 585(2/3): 325-337.
                                                               [2]   COSKUN  O, KANTER M, KORKMAZ  A,  et al. Quercetin, a
                                                                   flavonoid antioxidant, prevents and protects streptozotocin-induced
                                                                   oxidative stress and β-cell damage in rat pancreas[J]. Pharmacological
                                                                   Research, 2005, 51(2): 117-123.
                                                               [3]   ROGERIO A P, KANASHIRO A, FONTANARI C,  et al. Anti-
                                                                   inflammatory activity of quercetin and isoquercitrin in experimental
                                                                   murine allergic asthma[J]. Inflammation Research, 2007, 56(10):
                                                                   402-408.
                                                               [4]   COMALADA M, CAMUESCO D,  SIERRA S,  et al.  In vivo
                                                                   quercitrin anti-inflammatory effect involves release of  quercetin,
                                                                   which inhibits inflammation through down-regulation of the NF-κB
                                                                   pathway[J]. European Journal of Immunology, 2005, 35(2): 584-592.
                                                               [5]   TAKEKOSHI S, MATSUZAKI K, KITATANI K. Quercetin stimulates
                                                                   melanogenesis  in  hair follicle melanocyte of the mouse[J]. Tokai
                                                                   Journal of Experimental & Clinical Medicine, 2013, 38(4): 129-134.
                                                               [6]   KITAGAWA S, TANAKA Y, TANAKA M,  et al. Enhanced  skin
                                                                   delivery of quercetin by  microemulsion[J]. Journal of Pharmacy &
                                                                   Pharmacology, 2010, 61(7): 855-860.
                                                               [7]   KHALID N,  KOBAYASHI I, NEVES M  A,  et al. Microchannel
                                                                   emulsification study on formulation and stability characterization of
                                                                   monodisperse oil-in-water emulsions encapsulating quercetin[J].
                                                                   Food Chemistry, 2016, 212: 27-34.
            图 9   槲皮素水分散液和槲皮素多重乳液透皮 12 h 后在                    [8]   LIU L, TANG Y H, GAO C, et al. Characterization and biodistribution
                  角质层、活力表皮+真皮层中的槲皮素含量(A);                          in vivo of quercetin-loaded cationic nanostructured lipid carriers[J].
                                                                   Colloids and Surfaces B: Biointerfaces, 2014, 115: 125-131.
                  透皮处理后的猪皮截面显微镜图(B:a—槲皮素水
                                                               [9]   CHEN X, MCCLEMENTS D J, WANG J, et al. Coencapsulation of
                  分散液处理猪皮荧光通道;b—槲皮素水分散液处                           (–)-epigallocatechin-3-gallate and quercetin in particle-stabilized
                  理猪皮自然光通道;c—槲皮素多重乳液处理猪皮                           W/O/W emulsion gels: Controlled release  and bioaccessibility[J].
                                                                   Journal of Agricultural and Food Chemistry, 2018, 66(14): 3691-3699.
                  荧光通道;d—槲皮素多重乳液处理猪皮自然光通道)
            Fig. 9    Quercetin content in stratum corneum, active   [10]  CARLA C, OCTAVIO D, RAMON P, et al. Cross-linked chitosan/
                                                                   liposome hybrid system for the intestinal delivery of quercetin[J].
                    epidermi+dermis after treatment with quercetin   Journal of Colloid and Interface Science, 2016, 461: 69-78.
                    aqueous dispersion and  quercetin-loaded double   [11]  ADITYA N P, ADITYA S, YANG H, et al. Co-delivery of hydrophobic
                    emulsion (A); Microscope images of cross-section   curcumin and hydrophilic catechin by a water-in-oil-in-water double
                    of pig  skin after transdermal treatment (B: a—   emulsion[J]. Food Chemistry, 2015, 173: 7-13.
                    fluorescence channel of  pig skin treated  with   [12]  GALLARATE M,  CARLOTTI M  E, TROTTA M,  et al. On the
                    quercetin aqueous  dispersion; b—natural light   stability of ascorbic acid in emulsified systems for topical and cosmetic
                    channel of pig skin treated with quercetin aqueous   use[J]. International Journal of Pharmaceutics, 1999, 188(2): 233-241.
                    dispersion; c—fluorescence channel of pig skin   [13]  BINKS B P. Particles as surfactants—Similarities and differences[J].
                    treated with quercetin-loaded double emulsion;   Current Opinion in Colloid & Interface Science, 2002, 7(1/2): 21-41.
                    d—natural light channel of  skin treated with   [14]  LAMBA H, SATHISH K, SABIKHI L. Double emulsions: Emerging
                    quercetin-loaded double emulsion)              delivery system for plant bioactives[J]. Food and Bioprocess

                                                                   Technology, 2015, 8(4): 709-728.
            3   结论                                             [15]  WANG J, SUN Y J, YU M Y, et al. Emulsions stabilized by highly
                                                                   hydrophilic TiO 2 nanoparticles  via  Van der  Waals attraction[J].
                                                                   Journal of Colloid and Interface Science, 2021, 589: 378-387.
                (1)考察了各因素对 P/O/W 多重 Pickering 乳                [16]  SCHUSTER S, BERNEWITZ R, GUTHAUSEN G, et al. Analysis of
   164   165   166   167   168   169   170   171   172   173   174