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す 40 ࢤす 4 ㏳ ࡃ ጒ Vol.40, No.4
20 23 Ꭱ 4 ᰵ FINE CHEMICALS Apr. 2023
㐩䃧
䚣/MOFs ฺवᱽ᫆יࡃᕔ㘪䄰ᣔࣷᏁ⩕
*
䗏ᖖₐ喑݅⻭ᬻ 喑㐔䉑
喍๖≒ጒ͇๔႓ ㏧㏴႓̻ጒ⼸႓䮏喑๖≒ 300387喎
ᦅ㺮喟䛾ᆋᰶᱧᵳ᳣喍MOFs喎ڤᰶ℁㶕䲏⼜๔Ƞ䃫䃎ᕔᑧহ⩌➖Ⱕღᕔສぶх㞜➦ᕔ喑जВ҉ͧధჇࡃ䚣
⮱⤳ᘠ䒪Ҁ喑ϻ㔹倅⍥⻨䚣⮱⽠Ⴧᕔহיࡃᕔ㘪喑䃥็䚣/MOFs ฺवᱽ᫆Ό᭫ܧ℁⍥⻨䚣ᰡສ⮱יࡃ
ᕔ㘪ȡₑ喑䚣/MOFs ฺवᱽ᫆ጟᏁ⩕λ⩌➖эᙌȠᷭ≸Ƞיࡃぶ䶳ഌ喑ጟͧэ㐌יࡃݯ⮱⣜ԊᰬА৮ȡ
㐩䔝γ䚣ౕ MOFs ̷⮱ 3 ధჇࡃ∂喍㶕䲏ధჇȠႁᄮ㷲হ࣌Ѻ࠲∂喎喑䛺◦ϸ㏺γ 4 ᒞ৺䚣/MOFs
ฺवᱽ᫆יࡃᕔ㘪⮱㉍ࣷ䄰ᣔ∂喑ᄦ䚣/MOFs ฺवᱽౕ᫆יࡃ䲏⮱Ꮑ⩕Ό䔈㵹γᕨ㐀喑Ꭳᄦ䚣ధჇ
ࡃ⮱᱗Გ䔈㵹γᆂ᱈ȡ
ڠ䩛䃺喟䛾ᆋᰶᱧᵳ᳣喠ధჇࡃ䚣喠ϸႁ MOFs喠㏔㖁ࣺᏁ喠ᓛ⣜ධ喠⩌➖יࡃ
͚ఫܳㆨत喟Q643.36喠TB332 ᪴⡛ᴴ䃳喟A ᪴」㑃त喟1003-5214 (2023) 04-0775-08
Performance regulation and catalytic applications of
enzyme/MOFs composites
*
XING Enzheng, LIU Xiuming , GONG Jixian
喍College of Textile Science and Engineering, Tiangong University, Tianjin 300387, China喎
Abstract: Metal organic frameworks (MOFs), with excellent characteristics of large specific surface
area, good designability and biocompatibility, are ideal carriers of immobilized enzyme to improve the
stability and catalytic performance of free enzyme. Enzyme/MOFs composites, exhibiting much better
catalytic performance in comparison to free enzymes, have been widely used in in the fields of
biosensor, detection, catalysis and become an environmentally friendly substitute for traditional
catalysts. Herein, three enzyme immobilization methods on MOFs (surface immobilization, pore
encapsulation and in-situ encapsulation) were firstly introduced. Four factors influencing the catalytic
performance of enzyme/MOFs composites and the corresponding regulation methods were then
emphatically discussed. Finally, the catalytic applications of enzyme/MOFs composites were
summarized and the future development directions of enzyme immobilization were prospected.
Key words: metal-organic frameworks; enzyme immobilization; mesoporous MOFs; cascade reaction;
microenvironment; biocatalysis
䚣҉ͧ⩌➖יࡃݯ喑ᄦᏂ➖ڤᰶ倅Ꮣ➦ᐯᕔহ ͧγᑧ䚣⮱⽠Ⴧᕔহज䛺ฺҬ⩕ᕔ喑ϧЙ
倅יࡃ᩵⢴喑ₑ喑Ꭼ∈Ꮑ⩕λ䒨ጒ͇⮱⩌ϔߍጒ喑 ܧγధჇࡃ䚣ゃ⪒ [6-7] Вᩦڣ➦ᕔ喑Ꭳ䔈̭ₒ倅
[2]
[4]
[3]
[8]
[1]
ຯጒ͇ Ƞۉ͇ Ƞࡨ㢜࢘⩌ ࣷ㘪⎽ᐭࣾ ぶȡ♣ ڣיࡃᕔ㘪ȡⵁ⾣ϧঅߌᄳ䚣ధჇౕⷠ㏠ㆠノ Ƞ
[9]
㔹喑๖♣䚣⮱Ჱ䆎ౕ̭ψ⣜ධ͚Ხᭀࣾ⩌ᩦअ喑ຯᑧ ≨ᕔ◚ Ƞ㘣 [10] হ倅㖇➖ [11] ౕڲ⮱็ധ䉕̷喑⩞
䚥ȠᑧⷞȠ倅⍖Ƞࡃ႓䄂ݯВࣷ㜗䏘㖇䯳ぶ䘪ч䭺 λэ㐌ᱽ᫆℁㶕䲏⼜䒰ᄼ喑ᬍ∂ధჇᰡ็⮱䚣喑́
[5]
ѻ䚣⮱≨ᕔ 喑Ხ๔ౝ䭽ݣγ䚣⮱䭲Ꮑ⩕ȡ ज䃫䃎ᕔ䒰ጛȡₑ喑ధჇऻ⮱䚣ฺवᱽ᫆ႅౕ䉌
ᩣ⽬ᬒ喟2022-08-11; Ⴧ⩕ᬒ喟2022-10-11; DOI: 10.13550/j.jxhg.20220746
ധ䛾䶦Ⱋ喟పუ䛺◦ⵁࣾ䃎ܿ喍2017YFB0309800喎喠ᆞ͉Ⱞ䛺๔ឭ݈ጒ⼸喍2019TSLH0108喎喠Ⱞ䘕ڞᐧ⩌➖็㈃㏑㐡ᒏ̻⩌ᔮ
㏧㏴పუ䛺◦侹ბ喍䱿ᇈ๔႓喎ᐭᩫ䄫䷅喍KF2020207喎
҉㔲キϸ喟䗏ᖖₐ喍1999ÿ喎喑⩤喑ⶂธ⩌喑E-mail喟enzheng147@163.comȡ㖁㈨ϧ喟݅⻭ᬻ喍1980ÿ喎喑ຠ喑ޜ᪆ᢵ喑E-mail喟
liuxiuming@tiangong.edu.cnȡ
