Page 94 - 《精细化工》2023年第4期

g780g ㇫㏳ࡃጒ FINE CHEMICALS す 40 ࢤ

व➖喍CAT@Fe-BTC喎喑ᐭࣾγ⩕λᷭ≸䓴⅔ࡃ⅏হ 䓀ܧ喑჋⣝ᄦऱ⻺Ⱋᴴ➖⮱ᷭ≸ȡ
㠜䚇⮱℁㞟эᙌகȡ䚣/MOFs ฺवᱽ᫆ጟ㷘Ꭼ∈⩕ 䚣/MOFs ⩌➖ฺवᱽౕ᫆㇫㏳ࡃ႓Ƞ⩌➖эᙌ
λ㵭㈃⯾≸Ƞ丌৮ܳᲽȠ⫫⫲䃷᫚ぶэᙌᎠझ [63] 喑 হ⩌➖יࡃぶ̺ह䶳ഌ⮱Ꮑ⩕͚ڤᰶጕ๔⒉߈喑㶕
䯳᜽℁㞟∂Ƞ⩢ࡃ႓Ƞ㢔ٶȠࡃ႓ࣾٶぶ็⻺Ԏत 1 ᕨ㐀γ䘕ܳ䚣/MOFs ฺवᱽ᫆⮱㏱᜽ࣷᏁ⩕ȡ

㶕 1 䚣/MOFs ฺवᱽ᫆⮱㏱᜽ࣷᏁ⩕
Table 1 Composition and application of enzyme/MOFs composites
MOFs 䚣 Ꮑ⩕ ࣯㔰᪴⡛
SOM-ZIF-8 HRP Ӱ䔈ᴀ᫆⩌➖䭺㼐 [64]
HPPCN-222(Fe) GOx 㦎㤱㈃㏔㖁ࣺᏁ [65]
Mn-Zn-MOM NahK GlcNAc/GalNAc ⸤䚥ࡃ [66]
MOF-5 ChOx 㗳ధ䚴⅔ࡃܳ㼐 [67]
PCN-222(Fe) GOx 㦎㤱㈃হ ABTS ⅔ࡃ㏔㖁ࣺᏁ [68]
NH 2-MIL-53(Al) G4-hemin יࡃ 3,3',5,5'-ఈ⩟ധ㖁㠜㘧ܳ㼐 [69]
HP-PCN-224(Fe) GOxȠUricase ๖♣䚣ࡼहיࡃ㏔㖁ࣺᏁ [48]
ZIF-67(Co)/MWCNT HRP 䚣⩢ࡃ႓эᙌக [70]
L-proline ็Ⱕיࡃ㓌䛈ࣺᏁ [71]
UiO-66-S 30
MIL GOxȠHRP ោ㣹Ꮑ⩕ [72]
MHNiO HRPȠCyt C 2,4-ι⅜㠜䚇হݖ⺼ᭁᬻ⮱ᔘ䕌䭺㼐 [21]
GOx 㦎㤱㈃㏔㖁יࡃ [73]
Fe-MIL-88B-NH 2
+
+
Trimetallic-MOF DNAzyme Ag হ Hg ⮱䃳ݘ [74]
GLOX ࡃ႓䚣㏔㖁ࣺᏁக [75]
MIL-88B(Fe)-NH 2
ZIF-8 Hb H 2O 2 ⩢䔅࣌יࡃ [76]
Fe-BTC CAT ℁㞟эᙌக [62]
ZIF-8@P1 HRP 䔋㐚䭺㼐 BPA [77]
PlasEnMOF CATȠGOxȠHRP 倅᩵䚣Ӱ⭹⫴⇨⫄ [78]
∕喟SOM-ZIF-8 ͧࢂᮣᰶᎼ๔ႁ ZIF-8喠HPPCN-222(Fe)ͧܳ㏔็ႁ䨳ࢌ੶ധ MOF喠Gox ͧ㦎㤱㈃⅔ࡃ䚣喠Mn-Zn-MOM ͧ䩝ᣧ
ᱯ䨹ധ䛾ᆋᰶᱧᱽ᫆喠NahK ͧ N-Ά䚝ጞ㈃㘧⓭䚣喠GlcNAc/GalNAc ͧ N-Ά䚝⅕ധ㦎㤱㈃/N-Ά䚝ࡷΠ㈃㘧喠MOF-5 ͧ䨹ധ䛾ᆋᰶᱧ
ᵳ᳣喠PCN-222(Fe)ͧ䧮ധ䛾ᆋᰶᱧᵳ᳣喠NH 2-MIL-53(Al)ͧ⅕ധߌ㘪ࡃ䨊ധ䛾ᆋᰶᱧᵳ᳣喠HP-PCN-224(Fe)ͧܳ㏔็ႁ MOF喠Uricase
ͧᅬ䚥䚣喠MWCNT ͧ็෮ⷠ㏠ㆠノ喠UiO-66-S 30 ͧ⸧ࡃ䨳ധ MOF喠L-proline ͧ L-㙜⅕䚥喠MIL Ѫ䫱ส䠁኎ᴹᵪṶᷦ˗MHNiO ͧ
ܳᅯ㐀Ჱ䩺ധ MOF喠Fe-MIL-88B-NH 2 ͧ⅕ധߌ㘪ࡃ䧮ധ MOF喠Trimetallic-MOF ̶ͧ䛾ᆋ MOF喠MIL-88B(Fe)-NH 2 ͧ⅕ധߌ㘪ࡃ䧮
ധ MOF喠GLOX ͧ䅤⅕䚥⅔ࡃ䚣喠ZIF-8 ͧ䨹ധ䛾ᆋᰶᱧᵳ᳣喠Hb ͧ㵭㏏㯸⮪喠ZIF-8@P1 ͧ䔯䙺ߌ㘪ࡃ䚣-MOF ฺवᱽ᫆喠PlasEnMOF
ͧぶ⻨ၽҀ̶䚣䯳᜽䛾ᆋᰶᱧᵳ᳣ȡ

ѳౕధჇࡃ䚣䶳ഌϺᰶ 3 ᫦䲏䬛䷅όᒲ㼐۠喟喍1喎
4 㐀᲌䄚̻ᆂ᱈
㑧ͼᄦ䚣হ MOFs ͸䬡Ⱕο҉⩕⮱⌞ڒγ㼐喑Ⱕο
⩞λ͝ჹ⮱ज䃫䃎ᕔ喑MOFs जВ҉̭ͧ⻺ధ ҉⩕ᄳⰡᣒᒞ৺ݝ䚣㐀Ჱ⮱अࡃ喑䔈̭ₒ⮱ᣏ⾣ᰶ
Ⴧ䚣⮱⤳ᘠ䒪Ҁ喑ⵁ⾣ϧঅ䕇䓴㶕䲏ధჇȠႁᄮ㷲 ߖλͧధჇࡃ䚣≨ᕔ⮱᣽倅᣽ӈज㵹ӊᢛ喠喍2喎䚣
হ࣌Ѻ࠲೸ 3 ⻺᫦∂ݣิγ䚣/MOFs ฺवᱽ᫆ȡᄦ 䔈ڒႁ䯆͚⮱ព᪐ᱧݣᅇ̺ᬻ⶛喑䰭⌞ڒγ㼐䚣ౕ
λ 3 ⻺ధჇࡃゃ⪒喑䚣ܳݘధჇౕ MOFs ⮱㶕䲏Ƞႁ ព᪐হᄮ㷲䓴⼸͚Ჱ䆎⮱अࡃࣷ䔆ψअࡃౕᱧᷝ
䯆হڲ䘕喑ౕ̭Ⴧ⼸Ꮣ̷䖬ٺγ䚣Ჱ䆎⮱ᩦअ喑᣽ হߕ߈႓̷ᄦ䚣⮱ᒞ৺喠喍3喎㮪♣䚣/MOFs ฺवᱽ
倅γڣ⽠Ⴧᕔȡ⽠Ⴧᕔᰶݖλ䚣יࡃ≨ᕔ⮱᣽倅喑䚣/ ᫆ጟ㷘Ꭼ∈្䖀Ꮑ⩕λ⩌➖эᙌȠᷭ≸Ƞיࡃぶ䶳
ഌ喑ѳౕጒ͇᲎У̸⮱ⰥڠᏁ⩕្䖀䒰ᄾȡ
MOFs ฺवᱽ᫆⮱יࡃᕔ㘪ౕ჋䭲Ꮑ⩕͚ᅑͧ䛺
ᅪノ䔅ႅౕ䃥็⮱̺䋠喑MOFs ౕధჇࡃ䚣䶳
㺮ȡ᱙᪴㐩䔝γ 4 ⻺䄰ᣔיࡃᕔ㘪⮱ゃ⪒喟ϸႁ MOF
ഌϺ㶕⣝ܧጕ๔⮱ࣾᆂ⾧䬡ȡ䚣/MOFs ⩌➖יࡃᱽ
᣽倅γᏂ➖ࣷϔ➖⮱э䉕㘪߈喠ι㐡 MOF ㏠ㆠ❴⮱
᫆⮱Ꮑ⩕ጟ᠀ᆂݝ⩌➖эᙌகȠ⩌➖וႅȠ㢜➖䓽
ʌ-ʌ ڞ䒚Ꭰ䲏㐀Ჱᰶݖλ⩢ၽ⮱эᄩ喑́ᰶ๔䛼ᯡ䱟
䓀হࡨ⫄䃷᫚ぶ䶳ഌȡ䮼Ɑⵁ⾣⮱䔽ₒ⌞ڒ喑ऱ⻺
ౕใ⮱ࣺᏁ≨ᕔ͚ᓰ喠็䚣㏔㖁ࣺᏁ͚็䚣⮱ࡼ䄰י
ᕔ㘪᭫㦄⮱䚣/MOFs ฺवᱽ᫆ᄳ䔈̭ₒࣾᆂȡ
ࡃᬍ䰭ܳ⻨͚䬡Ҁ喑ࣺᏁ≨ᕔ᜽Ժ᣽ࡴ喠䕇䓴ౕ䚣ক
డ݈䕍̺हλ᪡Ҁ⣜ධ⮱ᓛ⣜ධᲒ෋ᑧ䚣⮱יࡃߌ㘪ȡ ࣯㔰᪴⡛喟
䚣/MOFs ฺवᱽ᫆ጟ᭫⹧ܧ䃥็хᐯ⮱ᕔ㘪喑 [1] YUSHKOVA E D, NAZAROVA E A, MATYUHINA A V, et al.