Page 92 - 《精细化工》2023年第4期

g778g ㇫㏳ࡃጒ FINE CHEMICALS す 40 ࢤ

੶喍TCPP喎䊲ฝั⤳ऻ喑ౕ 80 Ď̸ࣺᏁ 4 h ᓄݝι ฺवᱽ᫆喑Cu-TCPP ҉ͧڤᰶ๔䛼Ⴥ㘪ఏহ๔℁㶕
㐡䨉-ࢌ੶喍2D Cu-TCPP喎㏠ㆠ㛉ȡCU-TCPP ㏠ㆠ㛉 䲏⼜⮱㏠ㆠᎠझ喑Ჱᐧγ̭⻺⩕λᷭ≸ᄼܳၽ⮱⩌➖
䭱Ɑౕ⣨ⷠ⩢Ხ喍GCE喎㶕䲏喑䮼ऻౕ㶕䲏↶⼜䛾㏠ эᙌகȡ䄒эᙌகᄦ㗳ⷞ⮱㏬ᕔ㠰డͧ 0.3~300
ㆠㆿၽ喍Au NPs喎喑䕇䓴 Au—S 䩛ౕ⩢Ხ㶕䲏ԛ亝ጜ ȝmol/L喑ᷭ≸䭽ͧ 82.6 nmol/Lȡ
ധԛ亝ࢂ䨫 DNA喍SH-ssDNA喎喑Ҭ⩕ 6-ጜധ-1-ጞ䚴 䮑γ Cu ധι㐡 MOFs喑ⵁ⾣ϧঅᐭࣾγڣЃ䛾
喍MCH喎ࣨ䮑䲋➦ᐯᕔ DNA ॥䭱喑䮼ऻᄳ G4-㵭㏏ ᆋധ MOFsȡZHONG ぶ [39] 䔶⩕ Zr ധࢌ੶ MOF-545
㉍㙞⅔ᵥ䚣喍G4-hemin DNAzyme喎ԛ亝ౕ⩢Ხ㶕䲏喑 ధჇ㦎㤱㈃⅔ࡃ䚣喑Ꭳᄳ Fe ᑂڒࢌ੶͚ᓰ喑㣤ᓄ䚣/
ᓄݝധλ 2D Cu-TCPP হ G4-hemin DNAzyme ⮱⩢ MOFs ฺव➖ȲGox@MOF-545(Fe)ȳȡధჇࡃ䚣ౕბ
ࡃ႓эᙌகȡ䄒⩢ࡃ႓эᙌகज᭫㦄᣽倅 G4-㵭㏏ ⍖̸וႅ 7 d ऻ喑Ԋ⪆γ 92%⮱≨ᕔ喑㔹⍥⻨䚣ϲ
㉍㙞⅔ᵥ䚣⮱⽠Ⴧᕔ喑Cu-TCPP হ G4-㵭㏏㉍㙞⅔ Ԋ⪆γ 40%⮱≨ᕔȡNING ぶ [40] В⅜ࡃ䨌হ 5-⅕ധ
ᵥ䚣⮱ࡼ䄰҉⩕ᰶ᩵ౝᩫ๔γ⩢ࡃ႓৺ᏁԎत喑▢ 䬡㠜ι⩟䚥ݣิࣾٶ MOFs喑䕇䓴䊲ฝޒ⻨㣤ᓄࣇ
᩼Ꮣ䒰Вݺ⮱្䖀᣽倅 10 Ժ喑ຯఫ 3 ᝭⹧ȡ Ꮣϲͧ 4 nm ⮱ MOF ㏠ㆠ❴喑Ҭ⩕ H 2 O 2 ⅔ࡃ䗨㠜
ι䚇喑ݖ⩕⅔ࡃϔ➖䗨㠜䚹⮱⡊▚᩵Ꮑ喑ᐧ⿸γ䚣
䒲ߖᷭ≸ H 2 O 2 ⮱㈨㐌ȡ䄒 H 2 O 2 эᙌ㈨㐌䕇䓴䔈̭
ₒᐭࣾज⩕λ㦎㤱㈃⮱Ⴧ䛼ᷭ≸হ㦎㤱㈃⅔ࡃ䚣⮱
≨ᕔ≸Ⴧȡ
2.3 ็䚣㏔㖁ࣺᏁ
⩌➖Ҁ⮱㏳㘋ᓛ⣜ධڲႅౕ̭㈨݄⮱็䚣יࡃ
㈨㐌喑ऄ㜗♣⩹⩌➖יࡃ⮱ड़ࣾ喑ⵁ⾣ϧঅ㜡߈λ
็䚣㏔㖁ࣺᏁ⮱ᐭࣾ [41-42] ȡ็䚣㏔㖁ࣺᏁౕ̺ܳ⻨
͚䬡Ҁ⮱ᗲ̸ۢ喑䄞ᄩ͑͗ᝃ็͗䔋㐚ࣺᏁ⮱䔈㵹ȡ
ႁᒱज䄰হ㐀Ჱ⽠Ⴧ᭜䃫䃎ధჇ䚣হיࡃ㏔㖁ࣺᏁ
⮱͑͗ٵ۠᲎У [43] 喑㏔㖁ࣺᏁ⮱Ꭼ∈Ꮑ⩕᣽倅γי
ࡃ᩵⢴ [44] 喑䚣/MOFs 㐀Ჱͧ㏔㖁ࣺᏁ᣽ӈγ̭͗ᑧ
๔⮱Ꭰझȡ
MAN ぶ [45] ᄳ㯸⮪䚣喍Pro喎ȠΆ䚴㙞⅏䚣喍ADH喎
হ䒲఍ၽ喍NAD 喎ӊ⁎࠲ᄮౕ็ภ MOFs ⮱̺हภ
+

ఫ 3 2D Cu-TCPP ㏠ㆠ㛉⮱ݣิ喍a喎Ƞധλ 2D Cu-TCPP হ ڲ喑䮼ऻ ZIF-8 ౕ㶕䲏ใᐣ⩌䪬喑ࣨ䮑 ZIF-67 ऻᓄݝ
G4-hemin DNAzyme ⩢ࡃ႓эᙌகጒ҉䓴⼸⹧ᘼఫ 㖇व➖喍Pro@ZIF-8@ADH/NAD@ysZIF-8)ȡ䕇䓴䔽
喍b喎 [37] ᅯ⩌䪬∂ܳ㏔ధჇ㦎㤱㈃⅔ࡃ䚣হ䓐ᵦ䓴⅔ࡃ➖
Fig. 3 Schematic diagram of synthesis of 2D Cu-TCPP
nanofilm (a) and work process of electrochemical 䚣喑יࡃ᩵⢴䒰⍥⻨䚣Ⱕ℁᣽倅 5.8~13.5 Ժȡ䔽ᅯ
sensor based on Cu-TCPP and G4-hemin DNAzyme ⩌䪬͚̺Ⱕღ⮱䚣⠙⿸ᄮ㷲ౕ็ႁ MOFs ⮱̺हࡧ
(b) [37] ഌ喑ͧ㏠ㆠㆿၽ͚䚣⮱็ₒ͟㖁ࣺᏁ᣽ӈγ䯁⻨⾧

WANG ぶ [38] Ҭ⩕㶕䲏≨ᕔݯ䕇䓴࣌Ѻ࠲೸⮱᫦ 䬡হ䚣≨ᕔѺ◦͸䬡⮱э䉕䌜ᒱ喑Ӱ䔈⩌➖יࡃࣺ
∂ݣิγڤᰶࡃ႓ࣾٶߌ㘪⮱ 2D ࢌ੶ MOFs ㏠ㆠ Ꮑ⮱ᰶ᩵䔈㵹喑ݣิ䓴⼸ຯఫ 4 ᝭⹧ȡ

+
ఫ 4 ⩞࠲೸ౕ็ภ͚⾧ ZIF-8 ͚⮱̺Ⱕღ⮱䚣হ䒲఍ၽ喍Pro হ ADH/NAD 喎侞ߕ⮱͟㖁⩌➖יࡃࣺᏁ [45]
+
Fig. 4 Tandem biocatalytic reaction driven by incompatible enzymes and cofactor (Pro and ADH/NAD ) encapsulated in
multi-shelled hollow ZIF-8 [45]