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·1130· 精细化工 FINE CHEMICALS 第 35 卷

为进一步研究不同缓释材料的释药规律，采用 Colloids and Surfaces B: Biointerfaces, 2015, 134: 147-155.
[5] Jin X Q, Wang Q, Sun J, et al. Dual (pH- and temperature-) stimuli
零级动力学模型 [23] 、一级动力学模型 [23] 、Higuchi responsive nanocarrier with bimodal mesoporous silica nanoparticles
方程 [24] 以及 Korsmeyer-peppas 方程 [25] 对缓释数据进 core and copolymer shell for controlled ibuprofen-releasing:Fractal
feature and diffusion mechanism[J]. Microporous and Mesoporous
2
行拟合，结果如表 2 所示。由 R 可知，该缓释材料 Materials, 2017. DOI: 10.1016/j.micromeso.2017.05.003.
[6] Chen H Y, Lin Y S, Zhou H J, et al. Highly efficient alginate sodium
对阿维菌素的释放过程更加符合 Higuchi 方程，说 encapsulated chlorpyrifos/copper (II) Schiff base mesoporous silica
sustained release system with pH and ion response for pesticide
明阿维菌素的释放过程为扩散机制 [26] 控制。 delivery[J]. RSC Advances, 2016, 6(115): 114714-114721.
[7] Chen H Y, Lin Y S, Zhou H J, et al. Synthesis and characterization of
表 2 不同缓释材料的药物释放曲线拟合结果 chlorpyrifos/copper (II) schiff base mesoporous silica with pH
Table 2 Fitting results for release curves of AVM/Zn- sensitivity for pesticide sustained release[J]. Journal of Agricultural
and Food Chemistry, 2016, 64(43): 8095-8102.
HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS [8] He Q J, Gao Y, Zhang L X, et al. One-pot self-assembly of
2
R mesoporous silica nanoparticle-based pH-responsive anti-cancer
Dynamic pH nano drug delivery system[J]. Journal of Materials Chemistry, 2011,
mode value AVM/Zn- AVM/Cu- AVM/Mn- 21(39): 15190.
HOMS HOMS HOMS [9] Son Y, Park M, Choy Y B, et al.One-pot synthetic route to
4 0.88074 0.81552 0.95279 polymer–silica assembled capsule encased with nonionic drug
Zero-order molecule[J]. Chemical Communications, 2007, (27): 2799-2801.
equation 7 0.95558 0.86956 0.91081 [10] Chen J, Wang W, Xu Y Q, et al.Slow-release formulation of a new
10 0.96652 0.88028 0.95164 biological pesticide, pyoluteorin, with mesoporous silica[J]. Journal
4 0.91553 0.92170 0.98996 of Agricultural and Food Chemistry, 2011, 59(1): 307-311.
First-order 7 0.97745 0.92154 0.96576 [11] Gao C B, Izquierdo-Barba I, Nakase I, et al. Mesostructured silica
equation based delivery system for a drug with a peptide as a cell-penetrating
10 0.97435 0.94135 0.98754 vector[J]. Microporous and Mesoporous Materials, 2009, 122(1/2/3):
4 0.99650 0.97131 0.99134 201-207.
Higuchi [12] Zheng H Q, Huang Z H, Che S A. Mesostructured chitosan–silica
equation 7 0.97389 0.98783 0.99515 hybrid as a biodegradable carrier for a pH-responsive drug delivery
10 0.95281 0.98784 0.99003
system[J]. Dalton Transactions, 2012, 41(16): 5038.
Korsmeyer- 4 0.98699 0.88822 0.98752 [13] Li Y X, Zhou M S, Pang Y X, et al. Lignin-based microsphere:
Peppas 7 0.81153 0.93209 0.97157 preparation and performance on encapsulating the pesticide avermectin
equation 10 0.84577 0.92040 0.98528 [J]. ACS Sustainable Chemistry & Engineering, 2017, 5(4): 3321-3328.
[14] El-Safty S A, Hanaoka T. Microemulsion liquid crystal templates for
highly ordered three-dimensional mesoporous silica monoliths with
3 结论 controllable mesopore structures[J]. Chemistry of Materials, 2004,
16(3): 384-400.
[15] El-Safty S A, Hanaoka T. Monolithic nanostructured silicate family
采用一步法合成载药介孔硅，并引入锌、铜和 templated by lyotropic liquid-crystalline nonionic surfactant
mesophases[J]. Chemistry of Materials, 2003, 15(15): 2892-2902.
锰 3 种金属离子进行配位改性，制备出具有 pH 响 [16] Zhang F Q, Meng Y, Gu D, et al. A facile aqueous route to synthesize
应性的阿维菌素/金属离子介孔硅缓释材料。材料的 highly ordered mesoporous polymers and carbon frameworks with
Ia3hd bicontinuous cubic structure[J]. Journal of the American
表观构造呈现层状结构，其 N 2 吸附-脱附等温线为 Chemical Society, 2005, 127(39): 13508-13509.
[17] Dunphy D R, Sheth P H, Garcia F L, et al. Enlarged pore size in
具有 H2 型滞后环的 Langmuir Ⅳ型曲线。该缓释材 mesoporous silica films templated by pluronic F127: use of
料的释药曲线符合 Higuchi 动力学模型，遵循扩散 poloxamer mixtures and increased template/SiO 2 ratios in materials
synthesized by evaporation-induced self-assembly[J]. Chemistry of
控制机理。其中，铜离子和锌离子改性的缓释材料 Materials, 2015, 27(1): 75-84.
[18] Chang J H, Lee H, Jang S, et al. Facile preparation of size-controlled
表现出较好的 pH 响应性，当缓释达到 120 h，AVM/ mesoporous silica particles by metal-chelating surfactant micelle
Zn-HOMS 在 pH=4、7、10 时的累计释放率分别为 complexes[J]. Materials Letters, 2016, 173: 50-54.
[19] Kruk M, Asefa T, Jaroniec M, et al. Metamorphosis of ordered
55%，65%和 50%，而 AVM/Cu-HOMS 在相同条件 mesopores to micropores:periodic silica with unprecedented loading
of pendant reactive organic groups transforms to periodic
下的累计释放率则分别为 80%、72%和 75%。基于 microporous silica with tailorable pore size[J]. Journal of the
此，这种制备具有 pH 响应性的介孔硅-金属-农药缓 American Chemical Society, 2002, 124(22): 6383-6392.
[20] Zhou W Z, Zhao D Y, Wan Y. Ordered mesoporous molecular sieve
释材料的一步法合成法将为农药剂型的进一步开发 materials[M]. Beijing: Higher Education Press, 2013: 151.
[21] Che S A, Cao Y, Xing L, et al. Coordination bonding based
提供新的思路。 pH-responsive albumin nanoparticles for anticancer drug delivery[J].
Coordination Chemistry Reviews, 2013, 257(11/12): 1933-1944.
参考文献： [22] Wan M M, Qian W J, Lin W G, et al. Multiple functionalization of
SBA-15 mesoporous silica in one-pot: fabricating an aluminum-
[1] Lin Yueshun (林粤顺), Zhou Hongjun (周红军), Zhou Xinhua (周新 containing plugged composite for sustained heparin release[J].
华), et al. Preparation and properties of pH-responsive control release Journal of Materials Chemistry B, 2013, 1(32): 3897.
system of PAA/chlorpyrifos/amino functionalized mesoporous [23] Jain A, Jain S K. In vitro release kinetics model fitting of liposomes:
silica[J]. CIESC Journal (化工学报), 2016, 67(10): 4500-4507. an insight[J]. Chemistry and Physics of Lipids, 2016, 201: 28-40.
[2] Wibowo D, Zhao C X, Peters B C, et al. Sustained release of fipronil [24] Higuchi T. Mechanism of sustained- action medication[J]. Journal of
insecticide in vitro and in vivo from biocompatible silica Pharmaceutical Sciences, 1963, 52(12): 1145-1149.
nanocapsules[J]. Journal of Agricultural and Food Chemistry, 2014, [25] Korsmeyer R W, Gurny R, Doelker E, et al. Mechanisms of solute
62(52): 12504-12511. release from porous hydrophilic polymers[J]. International Journal of
[3] Alberti S, Soler-Illia G J, Azzaroni O. Gated supramolecular chemistry Pharmaceutics, 1983, 15(1): 25-35.
in hybrid mesoporous silica nanoarchitectures:controlled delivery and [26] Patil H, Tiwari R V, Upadhye S B, et al. Formulation and
molecular transport in response to chemical, physical and biological development of pH-independent/dependent sustained release matrix
stimuli[J]. Chem Commun (Camb), 2015, 51(28): 6050-6075. tablets of ondansetron HCl by a continuous twin-screw melt
[4] Tian Y, Kong Y, Li X J, et al. Light- and pH-activated intracellular granulation process[J]. International Journal of Pharmaceutics, 2015,
drug release from polymeric mesoporous silica nanoparticles[J]. 496(1): 33-41.