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第 35 卷第 7 期 精 细 化 工 Vol.35, No.7
201 8 年 7 月 FINE CHEMICALS July 2018

功能材料
pH 响应性阿维菌素/介孔硅的一步合成与释药性能

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沈之川，梁志铿，周红军 ，周新华，徐 华，陈铧耀
（仲恺农业工程学院 化学化工学院，广州市农业化学品高效利用重点实验室，广东 广州 510225）

摘要：以三嵌段共聚物 F127〔(EO) 106 (PO) 70 (EO) 106 〕为模板剂，正硅酸甲酯（TMOS）为硅源，阿维菌素(AVM)
为模型药物，通过一步法合成了载药介孔硅材料（AVM/HOMS），采用铜、锌、锰 3 种金属离子改性，制备了
具有 pH 响应性的缓释材料 AVM/Zn-HOMS、AVM/Cu-HOMS 和 AVM/Mn-HOMS，借助 FTIR、SEM、N 2 吸附-
脱附法和 TGA 表征了缓释材料，并研究了其在不同 pH 下的释放行为。结果表明：AVM/Zn-HOMS、
AVM/Cu-HOMS 和 AVM/Mn-HOMS 材料表面分别呈现层状、疏松多孔状以及气泡状结构，比表面积分别为
2
308.581、101.218 和 318.011 m /g，氮气吸附-脱附等温线类型为具有 H2 型滞后环的 Langmuir Ⅳ型。
AVM/Zn-HOMS 和 AVM/Cu-HOMS 呈现良好的 pH 响应性，AVM/Mn-HOMS 则未表现出明显的 pH 响应性，3
种材料的缓释行为均可用 Higuchi 动力学模型描述，释放过程受扩散机制控制。
关键词：一步法；阿维菌素；pH 响应性；缓释；功能材料
中图分类号：TQ450.6 文献标识码：A 文章编号：1003-5214 (2018) 07-1126-05

One-Step Synthesis and Drug Release of pH-responsive
Avermectin/Mesoporous Silica

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SHEN Zhi-chuan, LIANG Zhi-keng, ZHOU Hong-jun ,
ZHOU Xin-hua, XU Hua, CHEN Hua-yao
（Guangzhou Municipal Key Laboratory of Efficient Use of Agricultural Chemicals, College of Chemistry and Chemical
Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China）

Abstract: Avermectin/mesoporous silica (AVM/HOMS) was prepared via one-step method by using F127
[(EO) 106(PO) 70(EO) 106)] as template agent, methyl silicate (TMOS) as silicon source, avermectin as model
drug. Subsequently, copper, zinc and manganese ions were used to modify the resultant material. Finally,
three kinds of pH-responsive sustained release materials (AVM/Zn-HOMS, AVM/Cu-HOMS and
AVM/Mn-HOMS) were obtained. The prepared materials were characterized by FTIR, N 2
adsorption-desorption, SEM and TGA. And their release behavior under different pH values was studied.
The results showed that the surface of AVM/Zn-HOMS, AVM/Cu-HOMS and AVM/Mn-HOMS were
stratiform, multihole and bubbly, respectively. The specific surface areas of AVM/Zn-HOMS,
2

AVM/Cu-HOMS and AVM/Mn-HOMS were 308.581, 101.218 and 318.011 m /g. The N 2
adsorption-desorption isotherms of the three samples were the Langmuir Ⅳ type with hysteresis loops
type H2. AVM/Zn-HOMS and AVM/Cu-HOMS showed excellent sensitivities to pH, while
AVM/Mn-HOMS exhibited no obvious pH responsiveness. The release process of these materials could be
described by Higuchi kinetic model and was controlled by diffusion mechanism.
Key words: one-step method; avermectin; pH responsive; sustained release; functional materials
Foundation items: National Natural Science Foundation of China (21576303 and 21606262); Natural
Science Foundation of Guangdong Province (2016A030313375)

收稿日期：2017-08-11; 定用日期：2017-11-22; DOI: 10.13550/j.jxhg. 20170652
基金项目：国家自然科学基金（21576303，21606262）；广东省自然科学基金（2016A030313375）
作者简介：沈之川（1992—），男，硕士生。联系人：周红军（1975—），男，教授，电话：020-89003329，E-mail：hongjunzhou@163.
com。