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第 36 卷第 3 期 精 细 化 工 Vol.36, No.3
201 9 年 3 月 FINE CHEMICALS Mar. 2019

功能材料
4A 沸石对海藻酸钠/壳聚糖微球性能的影响

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张 雨，张鲁琪，焦学娟，胡亚卓，刘书亭，张保华
（青岛农业大学 新农药创制研究所，山东 青岛 266109）

摘要：以壳聚糖和海藻酸钠为载体、4A 沸石为性能改良剂，采用锐孔法制备了 4A 沸石/海藻酸钠/壳聚糖复合
微球，利用显微镜、SEM、FTIR 和 XRD 对复合微球进行了表征，考察了 4A 沸石对复合微球成球率和溶胀性
能的影响。结果表明：随着 4A 沸石添加量的增加，复合微球的质量和粒径均增大，添加 4A 沸石有利于复合微
球成球，成球率最高为 98.5%（添加 4A 沸石 1 g），且冷冻干燥后微球具有均匀的粒径和规则的球形形状。在不
同 pH（3、5、7）和温度下，4A 沸石能有效抑制微球的过度溶胀，但仍然保持良好的 pH 和温度敏感性。
关键词：4A 沸石；海藻酸钠；壳聚糖；微球；功能材料
中图分类号：TQ450.1.4 文献标识码：A 文章编号：1003-5214 (2019) 03-0387-06

Effect of 4A Zeolite on the Properties of Sodium
Alginate/Chitosan Microspheres

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ZHANG Yu, ZHANG Lu-qi, JIAO Xue-juan, HU Ya-zhuo, LIU Shu-ting, ZHANG Bao-hua
（New Pesticide Innovation and Research Institute, Qingdao Agricultural University, Qingdao 266109, Shandong, China）

Abstract: 4A zeolite/sodium alginate/chitosan composite microspheres were prepared by piercing method
using chitosan and sodium alginate as carrier material and 4A zeolite as performance modifier. The
microspheres were characterized by microscope, SEM, FTIR and XRD. The effect of addition amount of
4A zeolite on the granulation rate and swelling properties of composite microspheres was investigated. The
results showed that the mass and particle size of composite microspheres increased as the addition amount
of 4A zeolite increased. The addition of 4A zeolite was beneficial to the formation of composite
microspheres, and the highest percentage of granulation rate reached 98.5% (4A zeolite usage amount was
1 g). In addition, the freeze-dried composite microspheres had a uniform size distribution and regular
spherical shape. Under different pH value and temperature conditions, 4A zeolite could not only effectively
inhibit the swelling of microspheres, but also make the composite microspheres remain good pH and
temperature sensitivity.
Key words: 4A zeolite; sodium alginate; chitosan; microspheres;functional materials
Foundation items: National Natural Science Foundation of China (31501682); Natural Science Foundations
of Shandong Province (ZR2014CM039); Advanced Talents Foundation of Qingdao Agricultural University
(631333); Scientific and Technological Innovation Fund for Students of Qingdao Agricultural University
(2017548)

海藻酸钠是一种水溶性阴离子多聚糖 [1-3] ，壳聚 胀易破裂等缺点 [8,11] ，因此，不能很好地满足药物缓
[4]
糖是一种天然聚阳离子弱碱性多糖 。海藻酸钠和 释或组织支架的要求 [12-13] ，研究者常用蒙脱石 [14] 、
壳聚糖具有良好的生物相容性，常作为载药材料制 膨润土 [15] 、凹凸棒土 [16] 、明胶 [17] 等作为添加材料改
备缓释微球 [5-10] ，但制备的微球存在结构疏松、溶 善微球性能。

收稿日期：2018-05-05; 定用日期：2018-09-28; DOI: 10.13550/j.jxhg.20180322
基金项目：国家自然科学基金项目（31501682）；山东省自然科学基金项目（ZR2014CM039）；青岛农业大学高层次人才科研基金
（631333）；青岛农业大学生科技创新基金（2017548）
作者简介：张 雨（1996—），男，硕士生。联系人：张保华（1976—），男，博士，副教授，E-mail：zhangbaohua76@163.com。