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第 4 期 张光杰，等: 不同环糊精对角鲨烯的包合作用 ·707·

对角鲨烯有更大的包合常数有关。 度的升高而增加，且随着温度的升高，5 种环糊精
2.4 包合过程中热力学参数 的包合常数及增溶因子均不同程度地增大，其中
根据 1.2.5 所述方法计算包合过程中的热力学 55 ℃下 γ-环糊精的 K 值及增溶因子均为最大值。热
参数即焓值（ΔH）、熵值（ΔS）及吉布斯自由能（ΔG）， 力学参数表明，5 种环糊精的包合反应均为自发的
结果如表 3 所示。 吸热反应，且均为无序化程度升高的熵增加的过程。
温度升高有利于包合反应进行，且熵增加是角鲨烯
表 3 不同环糊精包合反应的热力学参数 分子进入环糊精空腔的主要驱动力。可为进一步研
Table 3 Thermodynamic parameters of inclusion reaction
by different cyclodextrins 究环糊精包合角鲨烯的分子机制及对角鲨烯性能的
环糊精种类 T/K ΔH/(J/mol) ΔS/〔J/(Kmol)〕ΔG/(J/mol) 影响提供依据及参考。
298.15 13573.4
α-环糊精 313.15 41010.4 183.1 16319.5 参考文献：
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