Page 161 - 《精细化工》2022年第12期

第 39 卷第 12 期 精 细 化 工 Vol.39, No.12
2 022 年 12 月 FINE CHEMICALS Dec. 2022

医药与日化原料
壳聚糖/β-甘油磷酸钠混合比对溶液-

凝胶转变性能的影响

1*
4
2
4
3*
姚勇波 1,2 ，周志军 ，申屠宝卿 ，张军峰 ，徐华伟 ，祝玲玲
〔1. 浙江大学 化学工程与生物工程学院，浙江 杭州 310027；2. 嘉兴学院 材料与纺织工程学院，浙江
嘉兴 314001；3. 浙江禾欣新材料有限公司，浙江 嘉兴 314033；4. 禾欣可乐丽超纤皮（嘉兴）有限公
司, 浙江 嘉兴 314033〕
摘要：将质量分数为 2%壳聚糖溶液（以浓度为 0.1 mol/L 的稀盐酸为溶剂）与质量分数为 24%的 β-甘油磷酸钠
（β-GP）水溶液按不同体积比混合后配成壳聚糖/β-GP 溶液，再制成壳聚糖/β-GP 膜。通过动态流变实验测定壳
聚糖/β-GP 溶液的储能模量与损耗模量，用 SEM、XRD 表征壳聚糖/β-GP 膜的结构。结果发现，4 ℃时，壳聚
糖/β-GP 溶液保持稳定的溶液状态；25 ℃下壳聚糖/β-GP 溶液能保持溶液状态 700 s，体积比为 6∶4 的壳聚糖/
β-GP 溶液（CP64）开始形成弱凝胶；温度>30 ℃后，壳聚糖/β-GP 溶液迅速发生溶液-凝胶的转变，β-GP 溶液
加入量的增加不仅能提高溶液-凝胶转变速率，还能使壳聚糖膜的结构更疏松。壳聚糖溶液/β-GP 溶液体积比变
化能影响溶液-凝胶转变过程，调控壳聚糖/β-GP 膜的结构。
关键词：壳聚糖；β-甘油磷酸钠；流变；热致溶液-凝胶转变；相互作用；医药原料
中图分类号：TQ152；TM53 文献标识码：A 文章编号：1003-5214 (2022) 12-2527-07

Effect of chitosan-sodium β-glycerophosphate mixing

ratio on the sol-gel transition properties

1*
1,2
3*
YAO Yongbo , ZHOU Zhijun , SHENTU Baoqing ,
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2
4
ZHANG Junfeng , XU Huawei , ZHU Lingling
[1. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang, China;
2. School of Materials and Textile Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China; 3. Zhejiang Hexin
New Material Co., Ltd., Jiaxing 314033, Zhejiang, China; 4. Hexin Kuraray Micro Fiber Leather (Jiaxing) Co., Ltd.,
Jiaxing 314033, Zhejiang, China]
Abstract: Chitosan/sodium β-glycerophosphate (β-GP) solution was prepared by adding β-GP aqueous
solution (mass fraction 24%) slowly in chitosan solution (mass fraction 2% with 0.1 mol/L hydrochloric
acid solution as solvent) with different volume ratio, and then chitosan/β-GP film was fabricated from the
solution obtained above. The storage modulus and loss modulus of chitosan/β-GP solution was analyzed by
dynamic geology, and the structure of chitosan/β-GP film was characterized by SEM and XRD. The results
showed that the chitosan/β-GP solution was stable at 4 ℃, while could maintain the stable solution state for
700 s at 25 ℃. The solution with volume ratio of chitosan solution to β-GP solution at 6∶4 formed weak
gel (CP64) at 25 ℃. When the temperature was above 30 ℃, sol-gel transition occurred quickly. With the
amount of β-GP solution added increased, the solution-gel transformation rate was improved and the
structure of chitosan film became looser. Therefore, the volume ratio of chitosan/β-GP solution could affect
the solution-gel transition process and regulate the structure of chitosan/β-GP membrane.
Key words: chitosan; sodium β-glycerophosphate; rheology; thermally induced solution-gel transition;
interaction; drug materials

收稿日期：2022-04-24; 定用日期：2022-07-08; DOI: 10.13550/j.jxhg.20220391
基金项目：国家自然科学基金青年项目（21704034）
作者简介：姚勇波（1986—），男，副教授。联系人：周志军（1974—），男，高级工程师，E-mail：zhouzj@hexin-puleather. com；申
屠宝卿（1965—），女，教授，E-mail：shentu@zju.edu.cn。