Page 140 - 《精细化工》2022年第3期

第 39 卷第 3 期 精 细 化 工 Vol.39, No.3
2022 年 3 月 FINE CHEMICALS Mar. 2022

中药现代化技术
丹参挥发油与蒲公英提取物复配物在化妆品中的应用

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吴 颖 ，刘 晴 ，唐 文 ，王佳其 ，王双旦 ，侯芙蓉
（1. 上海应用技术大学 化学与环境工程学院，上海 201418；2. 上海应用技术大学 香料香精技术与工
程学院，上海 201418）
摘要：分别测试了丹参挥发油、蒲公英提取物及其复配物的抗氧化、美白、抑菌、细胞毒性和体外皮肤渗透性，
考察丹参挥发油与蒲公英提取物复配后是否具有协同增效作用。结果表明，复配物的抗氧化活性比二者单独作
用效果更强，略高于阳性对照 V C ；丹参挥发油对酪氨酸酶活性的抑制作用强于阳性对照熊果苷，对酪氨酸酶的
抑制类型为竞争性抑制，抑制常数（K I ）为 0.0049 mg/L，丹参挥发油与蒲公英提取物两者之间对酪氨酸酶的抑
制无拮抗作用；复配物对金黄色葡萄球菌的抑制作用好于单一成分，与阳性对照硫酸链霉素效果相当；提取物
质量浓度为 100 mg/L 时无明显细胞毒性；丹参挥发油与蒲公英复配后，蒲公英提取物的皮肤累计渗透量比单独
作用时增大，丹参挥发油可促进蒲公英提取物的透皮吸收，复配物具有协同抗氧化和抑菌功效，无明显细胞毒
性，皮肤渗透性较好。
关键词：丹参挥发油；蒲公英；协同增效；抗氧化活性；美白；抑菌活性；细胞毒性；皮肤渗透
中图分类号：TQ658 文献标识码：A 文章编号：1003-5214 (2022) 03-0562-07

Application of complexes of Salvia miltiorrhiza volatile oil and
dandelion extract in cosmetics

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WU Ying , LIU Qing , TANG Wen , WANG Jiaqi , WANG Shuangdan , HOU Furong
（1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China; 2.
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China）
Abstract: The antioxidant activity, whitening, antibacterial activity, cytotoxicity and skin permeability in
vitro of Salvia miltiorrhiza volatile oil, dandelion extract and their complexes were tested. The synergistic
effects of Salvia miltiorrhiza volatile oil and dandelion extract were investigated. The results showed that
the antioxidant activity of the complexes was stronger than that of the two alone, slightly higher than that of
positive control V C. The results of enzyme kinetics showed that the inhibitory effect of Salvia miltiorrhiza
volatile oil on tyrosinase activity was stronger than that of arbutin, the positive control. The inhibitory type
of Salvia miltiorrhiza volatile oil on tyrosinase was competitive, and the inhibition constant (K I) was 0.0049
mg/L. There was no antagonistic effect between Salvia miltiorrhiza volatile oil and dandelion extract on
tyrosinase activity. The inhibitory effect of the complexes on Staphylococcus aureus was better than that of
the single component, which was similar to positive control, streptomycin sulfate. The extracts with a mass
concentration of 100 mg/L had no cytotoxicity. After complexing Salvia miltiorrhiza volatile oil and
dandelion extract, the cumulative permeability of dandelion extract was greater than that when acting alone,
and Salvia miltiorrhiza volatile oil promoted the transdermal absorption of dandelion extract. The
complexes of Salvia miltiorrhiza volatile oil and dandelion extract had synergistic antioxidant and
antibacterial effects, no obvious cytotoxicity, better skin permeability.
Key words: Salvia miltiorrhiza volatile oil; dandelion; synergistic effect; antioxidant activity; whitening;
antibacterial activity; cytotoxicity; skin permeability

收稿日期：2021-08-11; 定用日期：2021-11-10; DOI: 10.13550/j.jxhg.20210806
基金项目：上海市大学生创新训练项目（10110K208035-B11, 10110K208031-B11）
作者简介：吴 颖（1972—），女，副教授，E-mail：Wuying7210@163.com。