Page 63 - 《精细化工》2022年第9期

第 39 卷第 9 期 精 细 化 工 Vol.39, No.9
2022 年 9 月 FINE CHEMICALS Sept. 2022

功能材料
萃取非甾体抗炎药物材料的制备及性能

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李培英 1,2 ，赵嘉辉 ，刘 博 1,2,3,6 ，赖华杰 1,2,3,4,5,6*
〔1. 中国科学院广州化学研究所，广东 广州 510650；2. 中国科学院大学，北京 100049；3. 中科检测
技术服务(广州)股份有限公司，广东 广州 510650；4. 中国科学院新型特种精细化学品工程实验室，广东
广州 510650；5. 广东省电子有机聚合物材料重点实验室，广东 广州 510650；6. 中科广化（重庆）新
材料研究院有限公司，重庆 400714〕

摘要：通过 Radziszewski 反应制备了聚咪唑醋酸盐离子液体（PAIL），并涂覆在氧化纤维素层析纸（Oxi-CFP）
上得到萃取纸（Oxi-CFP@PAIL）。采用 ATR-IR、TGA、SEM 和 AFM 对其进行了表征，并探讨了 PAIL 制备条
件对 Oxi-CFP@PAIL 吸附托美汀、酮洛芬、萘普生和双氯芬酸 4 种非甾体抗炎药物（NSAIDs）的影响。结果表
明，PAIL 通过化学键成功地附着在 Oxi-CFP 表面上，同时 Oxi-CFP@PAIL 耐折度明显提高。60 ℃下制得的 PAIL
（质量分数为 5%）水溶液对 Oxi-CFP 进行浸泡，Oxi-CFP@PAIL 上 PAIL 的负载量最大，并且其对 4 种 NSAIDs
的单位面积吸附量最大。将萃取水溶液中含有羧基的 NSAIDs 的萃取纸用体积分数均为 1%的甲酸和乙酸铵（1
mol/L）水溶液的乙腈溶液进行解吸，并用三重四极杆液质联用仪（HPLC-MS/MS）检测，Oxi-CFP@PAIL 对 4
种 NSAIDs 回收率均>80%。该方法检出限和定量限分别在 0.02~0.10 μg/L 和 0.07~0.33 μg/L。
关键词：薄膜萃取；萃取纸；聚离子液体；非甾体抗炎药物；功能材料
中图分类号：TB34 文献标识码：A 文章编号：1003-5214 (2022) 09-1781-07

Preparation and properties of extracted materials for
non-steroidal anti-inflammatory drugs

1,2
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LI Peiying , ZHAO Jiahui , LIU Bo 1,2,3,6 , LAI Huajie 1,2,3,4,5,6*
[1. Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, Guangdong, China; 2. University of
Chinese Academy of Sciences, Beijing 100049, China; 3. CAS Testing Technical Services (Guangzhou) Co., Ltd., Guangzhou
510650, Guangdong, China; 4. CAS Engineering Laboratory for Special Fine Chemicals, Chinese Academy of Sciences,
Guangzhou 510650, Guangdong, China; 5. Guangdong Provincial Key Laboratory of Organic Polymer Materials for
Electronics, Guangzhou 510650, Guangdong, China; 6. New Materials Research Institute of CASCHEM (Chongqing) Co., Ltd.,
Chongqing 400714, China]

Abstract: Extraction paper (Oxi-CFP@PAIL) was fabricated by coating polyimidazolyl acetate ionic liquid
(PAIL), synthesized via Radziszewski reaction, on oxidized cellulose chromatography paper (Oxi-CFP) and
characterized by ATR-IR, TGA, SEM and AFM. Moreover, the influences of PAIL preparation conditions
on the adsorption performance of Oxi-CFP@PAIL for 4 kinds of nonsteroidal anti-inflammatory drugs
(NSAIDs) (tolmetin, ketoprofen, naproxen and diclofenac) were investigated. The results showed that PAIL
was chemically bonded to the surface of Oxi-CFP successfully, and significantly improved the folding
resistance of Oxi-CFP. Furthermore, the obtained Oxi-CFP@PAIL when the Oxi-CFP was immersed in the
PAIL prepared at 60 ℃ aqueous solution with a mass fraction of 5% had the largest PAIL load and
exhibited the best adsorption capacity per unit area for four NSAIDs. Desorption of 4 NSAIDS from
Oxi-CFP@PAIL using acetonitrile solution containing 1% (volume fraction) formic acid and ammonium
acetate (1 mol/L in water) followed by HPLC-MS/MS analyses indicated that recovery rate of
Oxi-CFP@PAIL for 4 NSAIDs were higher than 80%. It was found out that the detection limit and

收稿日期：2022-01-25; 定用日期：2022-04-07; DOI: 10.13550/j.jxhg.20220097
基金项目：广东省省级科技计划项目——粤东中科检测技术服务中心（2017A040403030）
作者简介：李培英（1995—），女，硕士生，E-mail：lipy@gic.ac.cn。联系人：赖华杰（1986—），男，高级工程师，E-mail：laihuajie@
gic.ac.cn。