Page 37 - 精细化工2019年第8期

第 36 卷第 8 期 精 细 化 工 Vol.36, No.8
201 9 年 8 月 FINE CHEMICALS Aug. 2019

功能材料
氧化石墨烯/丙酸氯倍他索分子捕获器的制备及性能

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王 芳 1,2 ，刘 敏 ，李小燕 ，吴宗远 ，刘 莉 ，朱 晨
（1. 广西民族大学 化学化工学院 广西高校食品安全与药物分析化学重点实验室，广西林产化学与工程重
点实验室，广西 南宁 530008；2. 广西民族大学 海洋与生物技术学院 广西高校微生物与植物资源利用
重点实验室，广西 南宁 530008）
摘要：以氧化石墨烯修饰聚乙烯滤板为内部支撑体，采用表面分子印迹技术，以丙酸氯倍他索为模板分子，3-
氨丙基三乙氧基硅烷为功能单体，正硅酸乙酯为交联剂，在内部支撑体表面进行分子印迹，制备了一种对丙酸
氯倍他索具有特异选择吸附能力的分子捕获器。分别采用 FTIR、FESEM、EDS、TGA 对分子捕获器的结构、
形貌、热稳定性进行了表征。并对其吸附性能进行了研究，结果表明，该分子捕获器对丙酸氯倍他索具有较好
的结合性能。将该分子捕获器作为固相萃取整体材料，结合高效液相色谱检测，应用于加标化妆品样品中丙酸
氯倍他索的选择性富集分离，方法检出限为 0.04 mg/L，准确性、精密度良好。分子捕获器可以重复使用 4 次，
具有良好的耐用性。
关键词：分子捕获器；固相萃取；丙酸氯倍他索；氧化石墨烯；表面印迹；功能材料
中图分类号：O652.6 文献标识码：A 文章编号：1003-5214 (2019) 08-1525-07

Preparation and Properties of Clobetasol Propionate Molecular
Capture Based on Graphene Oxide

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WANG Fang , LIU Min , LI Xiao-yan , WU Zong-yuan , LIU Li , ZHU Chen
（1. Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry,
Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering,
Guangxi University for Nationalities, Nanning 530008, Guangxi, China; 2. Guangxi Key Laboratory of Utilization of
Microbial and Botanical Resources, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities,
Nanning 530008, Guangxi, China）
Abstract: A solid phase extraction material with specificity extracting clobetasol propionate of molecular
capture was prepared by surface imprinting technique in combination with solid phase extraction column
sieve plate coated with graphene oxide. The molecular capture (MC) was prepared by using clobetasol
propionate as template molecule, 3-aminopropyltriethoxysilane as monomer and ethyl silicate as
cross-linker, respectively. The morphology, structure and thermostability of the molecular capture were
characterized by FTIR, FESEM, EDS and TGA, and its adsorption properties were studied. The results
showed that the molecular capture had binding performance to chlorbetasol propionate. This molecular
capture was used as a solid phase extraction material, combined with HPLC detection, for the selective
enrichment and separation of chlorbetasol propionate in cosmetics samples. It was found that this method
had good accuracy and precision and its detection limit was 0.04 mg/L. The durability test demonstrated
that the molecular capture could be reused at least 4 times with good durability.
Key words: molecular capture; solid phase extraction; clobetasol propionate; grapheme oxide; surface
imprinting technique; functional materials

收稿日期：2018-10-10; 定用日期：2019-03-12; DOI: 10.13550/j.jxhg.20180744
基金项目：国家自然科学基金项目（21545011，21165003）；广西自然科学基金项目（2016GXNSFAA380141）；广西科技基地和人才
专项（桂科 AD18126005）；广西民族大学科研基金项目（2017MDQN002）；广西高校中青年教师基础能力提升项目（2018KY0169）
作者简介：王 芳（1992—），女，实验员，硕士。联系人：刘 敏（1988—），女，助理研究员，E-mail：liumin7045@126.com；李
小燕（1961—），女，研究员，E-mail：lixiaoyan73515@163.com。