Page 39 - 《精细化工》2020年第1期

第 1 期 周 曦，等: 生物基可降解荧光聚酯的制备及性能研究 ·25·

酯对 hMSCs 无细胞毒性，即所合成的荧光聚酯具有 Gelation, biodegradation and biomedical applications[J]. Chemical
良好的生物相容性。 Society Reviews, 2012, 41(6): 2193-2221.
[3] Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and
gene delivery to cells and tissue[J]. Advanced Drug Delivery
Reviews, 2003, 55(3): 329-347.
[4] Nair L S, Laurencin C T. Biodegradable polymers as biomaterials[J].
Progress in Polymer Science, 2007, 32(8/9): 762-798.
[5] Michalet X, Pinaud F F, Bentolila L A, et al. Quantum dots for live
cells, in vivo imaging, and diagnostics[J]. Science, 2005, 307(5709):
538-544.
[6] Escobedo J O, Rusin O, Lim S, et al. NIR dyes for bioimaging
applications[J]. Current Opinion in Chemical Biology, 2010, 14(1):
64-70.
[7] Bagalkot V, Zhang L, Levy-Nissenbaum E, et al. Quantum
dot-aptamer conjugates for synchronous cancer imaging, therapy, and
sensing of drug delivery based on bi-fluorescence resonance energy
transfer[J]. Nano Letters, 2007, 7(10): 3065-3070.
[8] Farokhzad O C, Khademhosseini A, Jon S, et al. Microfluidic system
for studying the interaction of nanoparticles and microparticles with
图 9 BBPP-Cys 和 BBPP-Ser 对 hMSCs 的毒性效应
cells[J]. Analytical Chemistry, 2005, 77(17): 5453-5459.
Fig. 9 Cell viabilities of hMSCs treated with BBPP-Cys [9] Sumer B, Gao J. Theranosticnanomedicine for cancer[J].
and BBPP-Ser samples Nanomedicine, 2008, 3(2): 137-140.
[10] Pridgen E M, Langer R, Farokhzad O C. Biodegradable, polymeric
nanoparticle delivery systems for cancer therapy[J]. Nanomedicine,
3 结论 2007, 2(5): 669-680.
[11] Ghandehari H. Materials for advanced drug delivery in the 21st
（1）以生物基材料柠檬酸、蓖麻油和氨基酸为 century: A focus area for advanced drug delivery reviews[J].
Advanced Drug Delivery Reviews, 2008, 60(9): 956.
原料，通过简单、安全、经济的缩聚反应制备得到 [12] Yakimansky A V, Menshikova A Y, Shevchenko N N, et al. From
1
具有内在荧光特性的可降解聚酯。FTIR 和 HNMR polymeric nanoparticles to dye-containing photonic crystals: Synthesis,
self-assembling, optical features, and possible applications[J].
表明，氨基酸与柠檬酸侧链生成六元环状共轭结构，
Polymers for Advanced Technologies, 2010, 20(6): 581-588.
这使得聚酯具有内在荧光特性。 [13] Petros R A, De Simone J M. Strategies in the design of nanoparticles
（2）相较于未添加氨基酸的无荧光聚酯 PCCO， for therapeutic applications[J]. Nature Reviews Drug Discovery,
2010, 9(8): 615-627.
BBPP-Cys 和 BBPP-Ser 具有明显的紫外吸收和荧光 [14] Yang J, Zhang Y, Gautam S, et al. Development of aliphatic
发射，并且随着氨基酸含量的增加，BBPP-Cys 和 biodegradable photoluminescent polymers[J]. Proceedings of the
BBPP-Ser 的荧光强度逐渐增大。接触角和粒径测试 National Academy of Sciences, 2009, 106(25): 10086-10091.
[15] Jamieson T, Bakhshi R, Petrova D, et al. Biological applications of
分析表明，所合成的荧光聚酯具有较好的亲水性和 quantum dots[J]. Biomaterials, 2007, 28(31): 4717-4732.
生物相容性并且具有较小的粒径；力学性能测试和 [16] Jaiswal J K, Mattoussi H, Mauro J M, et al. Long-term multiple color
imaging of live cells using quantum dot bioconjugates[J]. Nature
降解实验表明，随着氨基酸含量的增加，具有荧光 Biotechnology, 2002, 21(1): 47-51.
特性的六元环状结构增加，六元环结构中酰胺键的 [17] Schmidt C E, Baier J M. Acellular vascular tissues: Natural
高稳定性以及能够增强分子间氢键作用的特性，使 biomaterials for tissue repair and tissue engineering[J]. Biomaterials,
2000, 21(22): 2215-2231.
得聚酯的拉伸强度增加，并降低了其降解速率。 [18] Liu Chunling (刘春玲), Jia Chunman (贾春满), Zhang Qi (张岐), et
（3）基于其具有良好的生物相容性、力学性能、 al. Synthesis and study on properties of anmagnetic resonance/
fluorescence bifunctional imaging molecular probe using low degree
降解性能和独特的荧光性能，所合成的生物基可降
of polymerization and narrow molecular weight distribution chitosan
解荧光聚酯为荧光标记和成像技术在组织工程、药 as carrier [J]. Fine Chemicals(精细化工), 2016, 33(2): 235-240.
物传递和成像等领域提供了新的思路。 [19] Zhang Y, Tran R T, Qattan I S, et al. Fluorescence imaging enabled
urethane-doped citrate-based biodegradable elastomers[J]. Biomaterials,
2013, 34(16): 4048-4056.
参考文献：
[20] Standardization Administration of the People's Republic of China
[1] Liu Q, Jiang L, Shi R, et al. Synthesis, preparation, in vitro ( 中国国家 标 准化管理 委员 会 ), GB/T 16886.5 — 2017
degradation, and application of novel degradable bioelastomers—A Biologicalevaluation of medicaldevices—Part 5: Tests for in vitro
review[J]. Progress in Polymer Science, 2012, 37(5): 715-765. cytotoxicity [S]. Beijing:Standards Press of China (中国标准出版
[2] Li Y, Rodrigues J, Tomas H. Injectable and biodegradable hydrogels: 社), 2017.