Page 34 - 《精细化工》2020年第1期

第 37 卷第 1 期 精 细 化 工 Vol.37, No.1
202 0 年 1 月 FINE CHEMICALS Jan. 2020

功能材料
生物基可降解荧光聚酯的制备及性能研究

周 曦 1,2 ，张志敏 1,2 ，王若男 1,2 ，涂伟萍 1,2 ，胡剑青 1,2*

（1. 华南理工大学 化学与化工学院，广东 广州 510641；2. 广东省绿色化学产品技术重点实验室，广
东广州 510641）

摘要：以天然生物基材料蓖麻油（CO）、柠檬酸（CA）和 L-半胱氨酸（L-Cys）或 L-丝氨酸（L-Ser）为原料，
1
合成一系列生物基可降解荧光聚酯（BBPP-Cys、BBPP-Ser）。采用 FTIR、 HNMR、紫外-可见光谱和荧光光谱
对其结构和荧光特性进行表征。同时，测量了聚酯的水接触角、粒径大小、力学性能、降解性能以及细胞毒性。
研究结果表明，悬挂在聚酯主链上独特六元环状结构是其产生荧光特性的原因。BBPP-Cys 在 265 nm 处有最强
紫外吸收，在 445 nm 处有最强荧光发射；BBPP-Ser 在 266 nm 处有最强紫外吸收，在 460 nm 处有最强荧光发
射。所合成聚酯具有良好的亲水性和较小粒径，拉伸强度范围为 1.21~1.95 MPa，在 0.1 mol/L NaOH 溶液中 7 d
降解率达到 60%以上。采用 MTT 法对荧光聚酯进行细胞毒性实验的结果表明，细胞增殖率均大于 90%，证明
其具有良好的生物相容性。
关键词：生物基材料；可降解聚酯；内在荧光特性；荧光聚合物；功能材料
中图分类号：R318.08；TQ323.4 文献标识码：A 文章编号：1003-5214 (2020) 01-0020-06

Preparation and properties of bio-based degradable fluorescent polyesters

1,2
1,2
1,2
1,2
Zhou Xi , Zhang Zhimin , Wang Ruonan , Tu Weiping , Hu Jianqing 1,2*
（1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641,
Guangdong, China; 2. Guangdong Provincial Key Laboratory of Green Chemical Technology, South China University of
Technology, Guangzhou 510641, Guangdong, China）
Abstract: A series of bio-based degradable fluorescent polyesters (BBPP-Cys and BBPP-Ser) were
synthesized from natural bio-based materials such as castor oil (CO), citric acid (CA) and L-cysteine
(L-cys) or L-serine (L-ser). The structure and fluorescence characteristics were characterized by FTIR,
1
HNMR, UV-Vis spectra and fluorescence spectra. At the same time, the water contact angle, particle
size, mechanical properties, degradation properties and cytotoxicity of the polyesters were measured.
The results showed that the unique six-membered ring structure suspended on the polyesters backbone
were responsible for their fluorescent properties. BBPP-Cys samples had the strongest UV absorption
at 265 nm, and their fluorescence emission signal was the strongest at 445 nm. For BBPP-Ser samples,
their strongest UV absorption and fluorescence emission were at 266 nm and at 460 nm, respectively.
The synthesized polyesters had good hydrophilicity and small particle size, the tensile strength ranged
from 1.21 MPa to 1.95 MPa. The degradation rate of the samples in 0.1 mol/L NaOH solution reached
over 60% in 7 days. The cytotoxicity of fluorescent polyesters was tested by MTT assay. The results
demonstrated that the cell viability of the synthesized fluorescent polyesters was all greater than 90%,
indicating that they had good biocompatibility.
Key words: bio-based material; degradable polyester; intrinsic fluorescence; fluorescent polymer;
functional materials

可生物降解聚合物一直是聚合物生物材料领域 领域得到广泛的应用 [1-4] 。使用可生物降解聚合物作
研究的重点，在组织工程、药物输送和生物成像等 为植入材料具有显著优点，在完成任务后，植入材

收稿日期：2019-04-11; 定用日期：2019-06-13; DOI: 10.13550/j.jxhg.20190301
基金项目：广东省自然科学基金（2018A030313483）
作者简介：周 曦（1994—），男，硕士生。联系人：胡剑青（1975—），男，副研究员，E-mial：glennhu@scut.edu.cn。