Page 191 - 《精细化工》2020年第8期

第 37 卷第 8 期 精 细 化 工 Vol.37, No.8
202 0 年 8 月 FINE CHEMICALS Aug. 2020

有机电化学与工业
羧基化高纯单壁碳纳米管修饰电极

对乙酰甲喹的高灵敏检测

1
汪洪武 1,2 ，何健丽 ，刘艳清 1,2* ，姚 夙 1,2
（1. 肇庆学院 食品与制药工程学院，广东 肇庆 526061；2. 食品与药品广东省实验教学示范中心，
广东 肇庆 526061）

摘要：采用羧基化高纯单壁碳纳米管（cSWCNTs）固载于金电极表面来构筑乙酰甲喹电化学传感器。运用循环
伏安法（CV）、差分脉冲伏安法（DPV）和电化学交流阻抗法（EIS）测定传感器的性能。结果显示，该传感
器对乙酰甲喹的电化学还原具有显著的催化性能，修饰电极的峰电流达到128.40 μA，是裸电极峰电流的 1167
倍。通过对传感器性能影响因素的考察，得到最优制备条件为 cSWCNTs 涂覆量为 4 μL（质量分数 0.10%分散
液），搅拌速度 1000 r/min，pH=7.0 的 PBS 浓度为 0.2 mol/L，0.5 V 电压下富集 30 min。在该条件下制备的传
感器峰电流与乙酰甲喹在 1~500 nmol/L 范围内呈良好的线性关系，相关系数为 0.998，方法的检出限为 0.76
nmol/L。该传感器被成功地应用于实际样品检测，加标回收率在 81.7%~124.0%。
关键词：乙酰甲喹；羧基化单壁碳纳米管；微分脉冲伏安法；电化学传感；功能材料
中图分类号：O657.1；TS207.53 文献标识码：A 文章编号：1003-5214 (2020) 08-1689-06

Highly sensitive detection of mequindox by high purity carboxyl
single-walled carbon nanotubes modified electrode

1
1,2
1,2
WANG Hongwu , HE Jianli , LIU Yanqing 1,2* , YAO Su
（1. School of Food & Pharmaceutical Engineering, Zhaoqing University, Zhaoqing 526061, Guangdong, China;
2. Guangdong Demonstration Center for Food and Drug Experimental Engineering Education, Zhaoqing University,
Zhaoqing 526061, Guangdong, China）
Abstract: High purity carboxyl single-walled carbon nanotubes (cSWCNTs) were fixed on the surface of
gold electrode to construct a novel mequindox electrochemical sensor. Cyclic voltammetry (CV),
differential pulse voltammetry (DPV) and electrochemical impedance (EIS) were used to investigate the
performance of the sensor. The results showed that the sensor had remarkable catalytic performance for the
electrochemical reduction of mequindox. The peak current of the modified electrode reached 128.40 A,
which was 1167 times that of the bare gold electrode. The factors affecting the performance of the
performed sensor were also optimized. The optimal conditions were determined as follow: coated volume
of cSWCNTs 4 μL (mass fraction of 0.10% dispersion), stirred speed 1000 r/min, and the performed
electrode being enriched at 0.5 V in 0.2 mol/L PBS (pH=7.0) for 30 min. Under these conditions, the peak
current of the sensor had a good linear relationship with concentration mequindox in the range of 1~
500 nmol/L, the correlation coefficient was 0.998, and the detection limit was 0.76 nmol/L. The sensor has
been successfully applied to the detection of actual samples with standard recovery rates of 81.7%~124.0%.
Key words: mequindox; high purity carboxyl single-walled carbon nanotubes; differential pulse voltammetry;
electrochemical sensor; functional materials

收稿日期：2020-02-25; 定用日期：2020-04-26; DOI: 10.13550/j.jxhg.20200137
基金项目：广东省教育厅科研项目（2017KCXTD032）；广东省大学生创新创业训练计划项目（201810580086，201810580085）
作者简介：汪洪武（1972—），男，博士，教授。联系人：刘艳清（1973—），女，博士，教授，E-mail：yqliu@zqu.edu.cn。