Page 33 - 《精细化工》2021年第11期

第 11 期 李德强，等: 果胶改性及其在药物递送载体中的应用进展 ·2179·

学的发展理念；（2）化学改性果胶对其生物活性存 [13] LI D Q, WANG S Y, MENG Y J, et al. Fabrication of self-healing
在什么影响，该类研究鲜见报道；（3）化学改性果 pectin/chitosan hybrid hydrogel via Diels-Alder reactions for drug
delivery with high swelling property, pH-responsiveness, and
胶在降解后是否会降低其生物相容性，目前相关报
cytocompatibility[J]. Carbohydrate Polymers, 2021, 268: 118244.
道较少；（4）果胶-无机纳米粒子复合材料的研究较 [14] YU L L, JIANG L N, WANG S Y, et al. Pectin microgel particles as
少，且无机纳米粒子对其生物相容性存在何种影响， high adsorption rate material for methylene blue: Performance,
equilibrium, kinetic, mechanism and regeneration studies[J].
尚不明确；（5）Pickering 乳液自模板法能够得到均
International Journal of Biological Macromolecules,2018,112:
一的药物递送载体，可用于果胶基药物递送系统的 383-389.
开发。总之，在认识到果胶自身性质的前提下，利 [15] MENG Y J, WANG S Y, GUO Z W, et al. Design and preparation of
用化学或物理手段改变其理化性质，掌握其规律， quaternized pectin-montmorillonite hybrid film for sustained drug
release[J]. International Journal of Biological Macromolecules, 2020,
能够有效增加果胶在药物缓释载体中的应用潜力。 154: 413-420.
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