Page 105 - 《精细化工》2021年第5期
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第 5 期 付 圣，等: C 60 -MnO 2 多功能纳米复合物的合成及其光动力学 ·959·
有良好的水溶性和生物相容性。体外实验表明，该
纳米复合物不仅可以作为 pH 响应的磁共振造影剂，
还能催化 H 2 O 2 产氧并增加 ROS 产率。在细胞水平上，
低剂量（质量浓度为 40 mg/L）的 C 60 -Mn-PEG-FA 在
2
100 mW/cm 的自然光下照射 5 min 可以杀伤 82%的
Hela 细胞，能实现对肿瘤细胞的特异性光诱导损伤，
是一种潜在的高效光敏剂。这种多功能的纳米复合
物为集诊断成像和治疗功能于一体的新型诊疗制剂
的设计提供了思路和参考。
图 6 不同质量浓度的 C 60 -Mn-PEG-FA 与 COS 7 细胞共 参考文献：
同孵育 24 h 后的细胞活性柱状图
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2
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