Page 48 - 《精细化工》2021年第8期

第 38 卷第 8 期 精 细 化 工 Vol.38, No.8
202 1 年 8 月 FINE CHEMICALS Aug. 2021

综论
负载 NHC-Pd 配合物催化 Suzuki

偶联反应的研究进展

赵 琛 1,2 ，熊 刚 1,2 ，丁 茯 1,2 ，孙亚光 1,2*

（1. 沈阳化工大学 理学院，辽宁 沈阳 110142；2. 辽宁省无机分子基化学重点实验室，辽宁 沈阳 110142）

摘要：钯催化的 Suzuki 偶联反应作为有效的构建碳-碳键的方法，在天然产物、药物全合成和有机合成工业中被
广泛应用。而目前广泛应用的含钯均相催化剂尽管反应活性高，但昂贵的钯金属盐或配合物不易回收，痕量残
留于目标产品或者废液中，导致目标产品重金属污染和环境污染等弊端，极大地增加了该反应的成本和降低了
产品的安全性。氮杂环卡宾钯配合物（NHC-Pd）在催化 Suzuki 偶联反应中具有反应活性高、稳定好等优点常
被用作异相催化剂的催化中心。该文从异相催化剂的载体材料如高分子聚合物材料、多孔硅材料、碳基材料、
金属-有机框架及磁性纳米粒子材料等出发，综述了近年来 NHC-Pd 在异相催化 Suzuki 偶联反应中的最新研究进
展，指出了这些催化剂存在的问题并对其发展方向进行了展望。
关键词：氮杂环卡宾；钯配合物；Suzuki 偶联；多相催化
中图分类号：O621.251；O641.4 文献标识码：A 文章编号：1003-5214 (2021) 08-1542-08

Research progress of Suzuki coupling reaction
catalyzed by loaded NHC-Pd complexes

1,2
1,2
1,2
ZHAO Chen , XIONG Gang , DING Fu , SUN Yaguang 1,2*
（1. College of Science, Shenyang University of Chemical Technology, Shenyang 110142, Liaoning, China; 2. Key
Laboratory of Inorganic Molecule-Based Chemistry of Liaoning Province, Shenyang 110142, Liaoning, China）
Abstract: As an effective method of constructing carbon-carbon bonds, the Suzuki coupling reaction of
palladium catalysis has been widely used in natural products, total pharmaceutical synthesis and organic
synthesis industries. The currently widely used palladium-containing homogeneous catalysts have high
reaction activity, but expensive palladium metal salts or complexes are not easy to be recycled, and traces
remain in the target product or waste liquid, causes heavy metal pollution of the target product and
environmental pollution, thus greatly increases the cost of the reaction and reduces the safety of the product.
The nitrogen heterocyclic carbene palladium complex (NHC-Pd) has the advantages of high reactivity and
good stability in catalyzing the Suzuki coupling reaction, and is often used as the catalytic center of
heterogeneous catalysts. The latest research progress of NHC-Pd in heterogeneous catalytic Suzuki
coupling reaction in recent year based on the support materials of heterogeneous catalysts such as
macromolecule polymer materials, porous silicon materials, carbon-based materials, metal-organic
frameworks and magnetic nanoparticles materials is reviewed. The problems existing in these catalysts are
pointed out and the development direction of these catalysts is prospected.
Key words: N-heterocyclic carbene; palladium complex; Suzuki coupling; heterogeneous catalysis

分子中碳-碳键的构建是现代有机合成最重要 的手段之一，并广泛应用于天然产物、药物全合成

收稿日期：2020-12-29; 定用日期：2021-03-23; DOI: 10.13550/j.jxhg.20201245
基金项目：国家自然科学基金（21671139）
作者简介：赵 琛（1996—），男，硕士生，E-mail：1020197947@qq.com。联系人：孙亚光（1972—），男，教授，E-mail：sunyaguang@
syuct.edu.cn。