Page 190 - 《精细化工》2022年第9期

第 39 卷第 9 期 精 细 化 工 Vol.39, No.9
2022 年 9 月 FINE CHEMICALS Sept. 2022

食品与饲料用化学品
食品级纳米乳液递送姜酮酚的体外生物可及率

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谢 甜 ，范 伟 ，覃静萍 ，肖 航 ，郭时印 ，唐忠海
（1. 湖南农业大学 食品科学技术学院，湖南 长沙 410000；2. 湖南农业大学 生物科学技术学院，湖南
长沙 410000；3. 麻省大学 阿莫斯特分校食品科学系，美国 马萨诸塞州阿莫斯特 01003）
摘要：为解决姜酮酚辛辣刺激性强、口服生物利用度低的问题，采用高压均质技术，以菜籽油为载体油、吐温
80 为乳化剂，制备了姜酮酚纳米乳液，考察了菜籽油质量分数对乳液粒径、Zeta 电位、游离脂肪酸释放率和姜酮
酚生物可及率的影响。结果表明，随着菜籽油质量分数的提高，纳米乳液粒径显著增大，Zeta 电位无明显变化。各
乳液小肠消化阶段游离脂肪酸释放率接近100%，油脂基本完全消化，当菜籽油质量分数过低（5%）时，乳液过于
黏稠，油滴消化速度减缓。姜酮酚在不同纳米乳液（菜籽油质量分数 5%、10%、15%和 20%）中的生物可及率均
显著高于对照组（未包封姜酮酚）（11.50%±0.20%），分别为 61.90%±1.14%、66.80%±1.56%、80.50%±2.50%和
86.20%±5.40%，表明纳米乳液递送体系能有效提高姜酮酚的生物可及率，且提升效率与菜籽油质量分数呈正相关。
关键词：姜；姜酮酚；纳米乳液；体外消化模型；生物可及率；食品用化学品
中图分类号：TS201.2 文献标识码：A 文章编号：1003-5214 (2022) 09-1908-09

In vitro bioaccessibility of paradol in food-grade
nanoemulsion-based delivery system

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XIE Tian , FAN Wei , QIN Jingping , XIAO Hang , GUO Shiyin , TANG Zhonghai
（1. College of Food Science and Technology, Hunan Agricultural University, Changsha 410000, Hunan, China; 2. College of
Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410000, Hunan, China; 3. Department of Food
Science, University of Massachusetts, Amherst MA 01003, USA）
Abstract: Nanoemulsions loaded with paradol were prepared by high pressure homogenization technology
using rapeseed oil as oil phase and Tween 80 as emulsifier to improve the low oral bioavailability and
pungent taste associated with paradol. The effects of rapeseed oil mass fraction on the particle size, Zeta
potential, free fatty acid release rate of nanoemulsions and bioaccessibility of paradol were investigated.
The result showed that the partide size of nanoemulsions increased significantly with the increase of
rapeseed oil mass fraction, while Zeta potential had no obvious change. Meanwhile, free fatty acid release
rate of different emulsions in simulated intestinal juice approached up to 100% with almost complete lipid
digestion. Emulsion with low rapeseed oil mass fraction (5%) was too viscous resulting in slowdown of lipid
digestion rate. The bioaccessibility of paradol encapsulated in nanoemulsions with different mass fraction of
rapeseed oil (5%, 10%, 15% and 20%) were 61.90%±1.14%, 66.80%±1.56%, 80.50%±2.50% and 86.20%±
5.40% respectively, significantly higher than that of the control group without encapsulation (11.50%±0.20%),
which indicated that the nanoemulsion delivery system could effectively improve the bioaccessibility of
paradol, and the improved efficiency was positively correlated with the mass fraction of rapeseed oil.
Key words: Zingiber officinale Rosc.; paradol; nanoemulsions; in vitro digestion models; bioaccessibility;
food chemicals

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姜酮酚（C 17 H 26 O 3 ）是从生姜中提取，分子结 烯酚（C 17 H 24 O 3 ）转化而来 ，结构式如图 1 所示。
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构与姜辣素、姜烯酚相似的芳香族酚酮 ，由 6-姜 研究表明，姜酮酚具有抗炎活性 、促细胞凋亡作

收稿日期：2022-03-29; 定用日期：2022-05-16; DOI: 10.13550/j.jxhg.20220253
基金项目：国家自然科学基金（31671858）；湖南省自然科学基金（2019JJ40114）
作者简介：谢 甜（1996—），女，硕士生，E-mail：919383992@qq.com。联系人：唐忠海（1979—），男，教授，E-mail：tzhonghai@163.com。