Page 116 - 《精细化工》2023年第4期

す 40 ࢤす 4 ᱌ ㇫ ㏳ ࡃ ጒ Vol.40, No.4
20 23 Ꭱ 4 ᰵ FINE CHEMICALS Apr. 2023

ߌ㘪ᱽ᫆
็ߌ㘪㏠ㆠٶ᩼ݯ NaYF ńYb,Tm@NaGdF ń
4
4
Yb@PDA/PEI-MnO ⮱ݣิࣷោ㣹ᕔ㘪
2

*
䲠ͦͦ喑ᰦ⑴ẍ喑ԋ ᒙ喑䊢৮」喑㥔Ⲭ俋喑იദۈ
喍⊆↌ጵ㠰๔႓ ࡃ႓̻⩌প⻾႓႓䮏Ąٵ䔈יࡃᱽ᫆ą᪆㗟䘕䛺◦჋侹ბ喑⊆↌ 䛾ࡻ 321000喎

ᦅ㺮喟䛴⩕ࣺⰥᓛΠ⋟∂ݣิγक़ᰶ̷䒙ᢏ㏠ㆠㆿၽ NaYF 4 ńYb,Tm@NaGdF 4 ńYbȠ㖇็ጡ㘧喍PDA喎Ƞ㖇Ά
☜χ㘧喍PEI喎হ MnO 2 ⮱็ߌ㘪㏠ㆠٶ᩼ݯ喍UPM喎喑Ռߖ TEMȠFTIRȠXPSȠUV-VisȠPL হ DLS 㶕ᒮγϔ
➖⮱ᒏ䆹Ƞࡃ႓㏱᜽Ƞٶ႓ᕔ䉕হㆿᒱܳጰ喑≸䄂γ UPM ⮱≨ᕔ⅔➖⻺ϔ⩌㘪߈Ƞᄦ⯽䚥ఈ⣜㉍喍TC喎⮱䉌
䒪̻䛷ᩫᕔ㘪喑㔰ᄌγ䉌䒪 TC ⮱ٶ᩼ݯ喍UPM/TC喎ౕ䓾㏏ใ喍NIR喎ٶ⚔̸⮱ោ㣹ᕔ㘪ȡ㐀᳉㶕ᬻ喑UPM ڤ
ᰶㆨ䓴⅔ࡃ⅏䚣≨ᕔ喑ౕ H 2 O 2 ႅౕহ NIR ٶ⚔̸जϔ⩌㓌ധ㜗⩞ധ̻ࢂ㏬ᔮ⅔ȡUPM/TC ⮱䒪㢜䛼ͧ 22.6%喑
Ҁใ䛷ᩫڤᰶ pH ৺Ꮑ➦ᒮ喑ౕ pH ͧ 5.0 ⮱⸤䚥⯽㑀۟⋟͚ 24 h ㉜⼜䛷㢜⢴ͧ 87.1%ȡౕߌ⢴ჳᏓ 1.2 W/cm 2
⮱ 980 nm NIR ٶ⚔ᄱ 10 min ऻ喑䉕䛼⊀Ꮣͧ 0.8 g/L ⮱ UPM/TC ᄦ๔㗍ᱳ㣹⮱ᱭ㣹⢴䓫ݝ 99.7%喑ោ㣹᩵᳉х
λ TC ᝃ UPM喑ॵ⣝ܧٶߕ߈-ោ⩌㉍ࡼहោ㣹᩵Ꮑȡ
ڠ䩛䃺喟̷䒙ᢏࣾٶ喠ι⅔ࡃ䩝喠㢜➖䉌䒪喠ٶߕ߈⇨⫄喠ㆨ䓴⅔ࡃ⅏䚣≨ᕔ喠ោ㣹ᕔ㘪喠ߌ㘪ᱽ᫆
͚ఫܳㆨत喟TB34喠O643 ᪴⡛ᴴ䃳⴮喟A ᪴」㑃त喟1003-5214 (2023) 04-0802-10

Preparation and antibacterial performance of multifunctional

nanophotosensitizers NaYF 4ńYb,Tm@NaGdF 4ńYb@PDA/PEI-MnO 2

*
JIN Dandan, CAO Xiaonan, YU Bin, ZHAO Pinzhang, XIAO Ruiqian, GONG Peijun
喍Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life
Sciences, Zhejiang Normal University, Jinhua 321000, Zhejiang, China喎

Abstract: Multifunctional nanophotosensitizers (UPM) composing of upconversion nanoparticles NaYF 4ń
Yb,Tm@NaGdF 4 ńYb, polydopamine, polyethyleneimine and MnO 2 were prepared by reverse microemulsion
method. The morphology, chemical composition, optical properties and size distribution of the products
obtained were then characterized by TEM, FTIR, UV-Vis, PL and DLS. Next, the reactive oxygen species
generation ability as well as the loading and release of tetracycline hydrochloride (TC) from UPM were
measured, and the antibacterial performance of TC-loaded nanophotosensitizers (UPM/TC) under near-
infrared (NIR) light irradiation was investigated. The results showed that UPM exhibited catalase-like activity
and could produce hydroxyl radical and singlet oxygen in presence of H 2O 2 when exposed to NIR light. The
loading capacity of TC in UPM was 22.6%, and the in vitro release of TC was pH-sensitive. The cumulative
release rate of UPM was 87.1% in phosphate buffer at pH 5.0 for 24 h. When exposed to 980 nm NIR light
2
(1.2 W/cm ) for 10 min, UPM/TC at a mass concentration of 0.8 g/L exhibited 99.7% bacterial inactivation
for E. coli and better antibacterial performance than free TC or UPM by virtue of the synergistic effect of
photodynamic and antibiotic sterilization.
Key words: upconversion luminescence; manganese dioxide; drug loading; photodynamic therapy; catalase-
like activity; antibacterial properties; functional materials

ᩣ⽬ᬒ᱌喟2022-08-04; Ⴧ⩕ᬒ᱌喟2022-11-25; DOI: 10.13550/j.jxhg.20220727
ധ䛾䶦Ⱋ喟⊆↌Ⱞڙ⯷ឭᱜᏁ⩕ⵁ⾣䃎ܿ䶦Ⱋ喍LGF20E020001喎喠⊆↌Ⱞ᫝㠄ϧ᝺䃎ܿ䶦Ⱋ喍2022R404B054喎
҉㔲キϸ喟䲠ͦͦ喍1996ÿ喎喑ຠ喑ⶂธ⩌喑E-mail喟1538146768@qq.comȡ㖁㈨ϧ喟იദۈ喍1978ÿ喎喑⩤喑ޜ᪆ᢵ喑E-mail喟skygpj@zjnu.cnȡ