Page 118 - 《精细化工》2023年第4期

g804g ㇫㏳ࡃጒ FINE CHEMICALS す 40 ࢤ

JPB-607A ಸ⏣㼐⅔≸ჇЗ喑̷⊤З⩢⻾႓Зகᰶ䭽 䛼⊀Ꮣͧ 30 g/L ⮱ KMnO 4 Ⅱ⏣⋟喑㐔㐚ᤲ៹ࣺᏁ
ڙथ喠ZHWY2008 ಸᥴᎷദڨマ喑̷⊤ᮧ೻ܳᲽЗ 6 hȡࣺᏁ㐀᲌ऻ喑ߍڒ 1 mL ᬍⅡΆ䚴喑ౕ 10000
கݣ䕍ᰶ䭽ڙथ喠MLS-3781L-PC ಸ倅ࢸ▚㣹䨲喑 r/min 䒙䕌̸⻨ᓰ 10 min喑ःܧధҀӊ⁎⩕ 5 mL ᬍ
ᬒ᱙Ძ̸֒Ꮴࡨ⫄கᷝᵗᐼч⹫喠SpectraMax iD5 ⅡΆ䚴≄⋑ 1 ⁎喑⩕ 5 mL Ⅱ≄⋑ 2 ⁎喑ࣨ䮑≄⋑⋟喑
䚣ᴴЗ喑㒻ప Molecular Devices ڙथȡ ፥⍖ⱌ⾧᎟✒ 6 h喑ᓄݝ 10 mg ㏠ㆠٶ᩼ݯ UCNPs@
1.2 ็ߌ㘪㏠ㆠٶ᩼ݯ喍UPM喎⮱ݣิ PDA/PEI-MnO 2 喑䃝ͧ UPM-1ȡ䄰᪡ KMnO 4 Ⅱ⏣⋟
仃ٵ࣯㔰 ᪴ ⡛ [23] ᫦∂ݣิ̷ 䒙ᢏㆿၽ ⩕䛼ܳݘͧ 60 হ 120 ȝL喑ᓄݝ⮱㏠ㆠٶ᩼ݯܳݘ
UCNPsȡ♣ऻ喑ౕ 50 mL ళᏂ☔⨣͚ӊ⁎ߍڒ 8 mL 䃝ͧ UPM-2 হ UPM-3ȡᄦλ̺⌨ߍ KMnO 4 ⏣⋟⮱
⣜ጞ☤Ƞ0.65 mL Lgepal CO-520Ƞ2 mL 䉕䛼⊀Ꮣ 5 Ҁ㈨喑ᕨᤲ៹ࣺᏁᬣ䬡㐡ᠮͧ 8 h喑ᓄݝ̺क़ MnO 2
g/L ⮱ UCNPs ⣜ጞ☤ܳ᪐⋟হ 75 ȝL क़ 5 mg PEI ⮱ ⮱ฺवㆿၽ UCNPs@PDA/PEI喑䃝ͧ UPȡUPM ⮱
⅕Ⅱ喑ᤲ៹ 30 min ऻߍڒ᫝凉䙺ݣ⮱ 25 ȝL 䉕䛼ܳ ݣิ̻䒪㢜ȠROS ϔ⩌ᱧ⤳হ⩕λٶߕ߈-ࡃ႓ࡼह
᪝ͧ 25%⮱ DA Ⅱ⏣⋟喑ᤲ៹ 2 h ऻߍڒ 30 ȝL 䉕 ោ㣹⹧ᘼఫຯఫ 1 ᝭⹧ȡ

ఫ 1 ㏠ㆠٶ᩼ݯ⮱ݣิ̻䒪㢜䓴⼸⹧ᘼఫ喍a喎ȠROS ϔ⩌ᱧ⤳ఫ喍b喎হ⩕λٶߕ߈-ࡃ႓ࡼहោ㣹⹧ᘼఫ喍c喎
Fig. 1 Scheme illustration of preparation and drug loading of the nanophotosensitizer (a), mechanism of ROS generation (b),
and application in the photodymanic-chemo synergistic antibacterial treatments (c)

1.3 㐀Ჱ㶕ᒮ̻ᕔ㘪≸䄂 ٶܳٶٶᏓ䃎䔈㵹≸Ⴧ喑ᄳᵤ৮ܳ᪐ౕᬍⅡΆ䚴͚
1.3.1 ㏱᜽Ƞ㐀Ჱ̻ᕔ䉕㶕ᒮ 䙺᜽䉕䛼⊀Ꮣͧ 1 g/L ܳ᪐⋟喑В 980 nm ⓭ٶͧ⓭
FTIR喟⩕ KBr ࢸ❴∂䔈㵹≸䄂喑∏᪝㠰డ喟 ࣾٶ喑∏䪬㠰డ 300~700 nmȡICP ܳᲽ喟ा 5 mg
–1
4000~500 cm ȡTEM喟ጒ҉⩢ࢸ 200 kVȡXPS喟䛴 ᵤ৮͚ߍ 0.5 mL ⢸Ⅱ喑60 Ď̸⊵㼐 6 h喑᝭ᓄ⏣⋟
⩕ X ᄱ㏬ٶ⩢ၽ㘪䅞ЗܳᲽధҀᵤ৮͚᝭क़ᰶ⮱ٰ ߍⅡჇღ㜠 25 mL喑⼭䛷̭ჇԺ᪝ऻ䔈㵹 ICP ≸䄂喑
㉍ȡ㏠ㆠㆿᏓহ Zeta ⩢Ѻ喟ᄳᵤ৮ܳ᪐ౕ䊲㏜Ⅱ ᵦᢛᴴ۳ᰟ㏬∂喍y = 0.99614x + 0.03374喑R =
2
喍pH = 6.72喎͚䙺᜽䉕䛼⊀Ꮣͧ 0.3 g/L ܳ᪐⋟喑ౕ 0.9992喎⶛Ⴧᵤ৮⏣⋟͚ Mn ⮱䉕䛼⊀Ꮣ喑ᵦᢛᐼ
2+
25 Ď̸В㜗ߕ≸䛼὎ᐼ≸䄂喑⩞ 3 ⁎≸䄂㐀᳉䃎ツ 喍1喎䃎ツᓄݝٶ᩼ݯ͚ MnO 2 ⮱䉕䛼ܳ᪝ȡ
Ꭰ౴թহռጛȡUV-Vis喟ᄳᵤ৮ߍڒࣨ⻨ၽⅡ͚䙺 86.94Vn uu Mn U 2+
᜽䉕䛼⊀Ꮣͧ 0.3 g/L ܳ᪐⋟喑䊲ฝܳ᪐ 5 min ऻ䔈 w(MnO 2 )/%= f100 喍1喎
54.94 m
㵹≸䄂喑∏䪬㠰డ 300~800 nmȡࣾٶᕔ㘪喟䛴⩕㢔 UPM