Page 47 - 《精细化工》2023年第4期
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す 4 ᱌                  ᑍუᏤ喑ぶ:  ᓛ䕇䖀ࣺᏁக͚㇫㏳ࡃ႓৮व᜽࢞䮖ጒ㞧ⵁ⾣䔈ᆂ                                    g733g


            ⋟喎⮱хࡃጒ㞧࣯᪝̸喑͆☜䚥⮱䒙ࡃ⢴䓫 97.1%喑                         ⮱䛺⅛⯽᭜็⩕䕁ᰶᱧव᜽͚䬡Ҁ                [49-50] ȡ䛺⅛ࡃࣺ
            Ά䛈䚥⮱䔶᠖ᕔͧ 91.4%ȡ䒰͸λ䜉ᐼ䬡⁴⅔ࡃࣺ                          Ꮑ᭜ᑧᩫ☚ࣺᏁ喑Ꭳ́䛺⅛⯽ࣵ䲋፥≨∩喑ऄ☚Ხ
            Ꮑ喑䔋㐚ࣺᏁڤᰶ᩵⢴倅Ƞᬣ䬡ⴚȠღᭀᣔݣ≮ᔮ                             ᭀࣾ⩌ޔ◵ܳ㼐喑ࣾ⩌✳◥喑఍㔹喑䜉ᐼࣺᏁக͚
            ぶх◦喑⊵䮑γ⅔ࡃ䓴⼸͚ࣹ⅔Ⅱܳ㼐ፓᲒ⮱Ⴖڕ                             ⮱䛺⅛ࡃࣺᏁ䕇፥ౕ 0~5  Ď䒰ѻ⮱ࣺᏁ⍖Ꮣহޔ
            䮽ᗐহ㏼≻ᢌ๞ȡ                                           ◵ᤲ៹̸䔈㵹喑⩌ϔ᩵⢴ѻȡₑใ喑㮪♣̭ψ䛺⅛
                                                               ⯽ౕ䒰ѻ⍖Ꮣ℁䒰⽠Ⴧ喑ѳ㠒ऻ㐚ࣺᏁ⍖Ꮣ䒰倅喑
                                                               ϺႅౕႶڕ䮽ᗐȡᓛ䕇䖀ࣺᏁகឭᱜ⮱䔈ₒͧࣾᆂ
                                                               倅᩵Ƞजᣔ⮱䛺⅛ࡃࣺᏁহ䛺⅛⯽ࣺᏁጒ㞧᣽ӈγ
                                                               ᰶ᩵⮱䕁ᒱȡ
                                                                   ݺጟ䔝ࣷ喑2,4,5-̶⅌⏡㠜᭜䛺㺮⮱ࡨ㢜͚䬡

                                                               Ҁ喑ज⩞ 1,2,4-̶⅌㠜Ⱑᣒ⏡ࡃव᜽ȡ䮑γݺ䔝᫦∂喑
                  ఫ 13   ᓛ䕇䖀͚͆☜䚥⅔ࡃ⩌᜽Ά䛈䚥           [44]         ᑍݖ䯱䄫䷅㏱      [51] 䔅ݖ⩕㏼ڥ⮱ Gatterman ࣺᏁౕᓛ
            Fig. 13    Oxidation of acrylic acid to glyoxylic acid in
                     microchannel reactor [44]                 䕇䖀ࣺᏁக̻䜉ᐼࣺᏁகⰥ㐀व⮱ࣺᏁ㷲㒛͚⩞

                                                               2,4,5-̶⅌㠜㘧倅᩵व᜽γ 2,4,5-̶⅌⏡㠜喍ఫ 15喎ȡ
                 ㏑㐡㉍⩌ϔ㏑㐡⮱㣞䊈ᅁጒ㞧喍Lyocell process喎                ᓛ䕇䖀ࣺᏁகͧڲᒱ 1 mm ⮱㖇ఈ⅌Ά☜℈㏳ノ㏬
            ͚В N-⩟ധॄ੶-N-⅔ࡃ➖喍NMMO喎ͧ⏣ݯ                  [45] ȡ   వȡຯఫ 15 ᝭⹧喑2,4,5-̶⅌㠜㘧̻ NaNO 2 ౕ HBr
            Ⱋݺ喑NMMO ⩞ι⅔ࡃⷠיࡃ䓴⅔ࡃ⅏⅔ࡃ N-⩟                          ႅ̸ౕ⮱䛺⅛ࡃࣺᏁౕݺ㒛 T ಸ⌤वக⮱ᓛ䕇䖀ࣺ
            ധॄ੶⩌ϔ喑ࣺᏁౕ䜉ᐼࣺᏁக͚䔈㵹                   [46-47] ȡͧ᣽    Ꮑக͚λ–10  Ď䶧ݖ䔈㵹ȡᅪノ⤳䃧̷ HBr ̻ 2,4,5-
            倅ڣ⩌ϔ⮱Ⴖڕᕔ喑BAUMEISTER ぶ               [48] 䛴⩕ノ䖀      ̶⅌㠜㘧⮱➖䉕⮱䛼℁ͧ 2ń1喑ѳ჋䭲̷ι㔲ᰭҠ
            ڲᒱͧ 1 mm ⮱ࣺᏁக὎಄喑㏱㷲᜽ᕨ䪬ͧ 750 mm                      ➖䉕⮱䛼℁ͧ 4ń1喑ѻλₑթчᄩ㜡ޜࣺᏁࣾ⩌ൢ
            ⮱ᓛ䕇䖀ࣺᏁக喑䔈㔹ౕₑࣺᏁக͚ⵁ⾣γ⩞䓴⅔                             උᓛ䕇䖀ࣺᏁகȡᄳ̺⽠Ⴧ⮱ 2,4,5-̶⅌㠜ധ䛺⅛⯽
            ࡃ⅏⅔ࡃ N-⩟ധॄ੶व᜽ NMMO ⮱ࣺᏁጒ㞧হߕ                         ⰡᣒԿڒ㷲ᰶ⅏⏡䚥হ䨉ㆶ⮱ࣺᏁ䜉喑ޔ◵ᤲ៹̸
            ߈႓喍ఫ 14喎ȡࣺᏁ䓴⼸͚喑䶱☚ݝࣺᏁ⍖Ꮣ⮱ N-                         λ 70  Ď䓲䕌ࣾ⩌⏡ࡃࣺᏁ⩌᜽ 2,4,5-̶⅌⏡㠜喑ᰭ
            ⩟ധॄ੶হ䓴⅔ࡃ⅏Ꭳ㵹∢ڒ⌤वக喑♣ऻ䔈ڒᓛ                             倅ᩣ⢴ज䓫 93.3%ȡ䕇䓴䄰᪡ T ಸ⌤वகহᓛ䕇䖀
            䕇䖀ࣺᏁக䔈㵹ࣺᏁȡᒀक़ᰶ䉕䛼ܳ᪝ͧ 1%ι⅔ࡃ                           ࣺᏁக⮱ᅧᄥ喑व᜽㻱὎ᒵღᭀᩫ๔ݝࡰٸ㏔ȡ䛴
            ⷠ⮱ࣺᏁ⋟ౕ⍖Ꮣ 60  ĎȠ։⪆ᬣ䬡 13.90 min ⮱᲎                   ⩕ㆨѩ⮱ࣺᏁக䔈㵹ःА㠜㘧⮱䛺⅛ࡃ喑䔅जВВ
            У̸≮㏼ࣺᏁகᬣ喑N-⩟ധॄ੶⮱䒙ࡃ⢴倅䓫 98%喑                         хᐯ⮱ᩣ⢴喍88.2%喎व᜽ⰥᏁ⮱ⷅ㠜               [52] ȡ
            NMMO ⮱ᩣ⢴ͧ 93.5%ȡ䕇䓴ߕ߈႓ⵁ⾣⶛ჇࣺᏁ
            ⮱≨ࡃ㘪ͧ 69.5 kJ/mol喑㶕ᬻ⅔ࡃࣺᏁ̺ऄэ䉕䭽
            ݣ喑䒙ࡃ⢴̻։⪆ᬣ䬡ჳܴⰥڠ喑఍㔹喑ࣺᏁ㻱὎
            ज䕇䓴෋ߍࣺᏁக὎಄ᓄВౕ̭Ⴧ㠰డڲ䄰अȡϻ
            ㏼≻হႶڕ͑᫦䲏㔰㭾喑䄒䔋㐚ࣺᏁጒ㞧जᰬАጒ

            ̷͇⣝㵹⮱䜉ᐼ䬡⁴ࣺᏁጒ㞧ȡ
                                                               ఫ 15   ᓛ䕇䖀ࣺᏁக͚ 2,4,5-̶⅌㠜㘧䛺⅛ࡃव᜽ 2,4,5-
                                                                            [51]
                                                                     ̶⅌⏡㠜
                                                               Fig. 15    Synthesis of 2,4,5-trifluoro-bromobenzene  by
                                                                       diazotization of 2,4,5-trifluoroaniline in microchannel
                                                                       reactor [51]

                                                                   ᓄ⯷λ 3D ក࢝ឭᱜহ⓭ٶᓛߍጒឭᱜ⮱䔈ₒ喑

            ఫ 14   ᓛ䕇䖀ࣺᏁக͚ N-⩟ധॄ੶⅔ࡃव᜽ N-⩟ധॄ                    ϧЙजВ䃫䃎ݣ䕍ฺᱯ㐀Ჱ⮱ᓛ≮ᣔ㟜❴喑Ჱᐧ⌤व᩵
                   ੶-N-⅔ࡃ➖   [48]                              ᳉ᰡສȠ䕇䛼ᰡ๔⮱ᓛ䕇䖀ࣺᏁகȡ᫪ప䋰䄫䷅㏱                      [53]
            Fig. 14    Synthesis of  N-methylmorpholine-N-oxide by   ݖ⩕下⻿⓭ٶᓛߍጒឭᱜݣิܧฺᱯᲱಸ⮱倅ჳ
                      oxidation of  N-methylmorpholine in microchannel
                      reactor [48]                             ᏓȠ๔Ҁ⼜ࣅㆠ㏔ⶩ⵲䚥⯽ᱽ䉕⮱ᓛ≮Ҁ㟜❴
                                                               喍MFCs喎ȡ䄒㟜❴⮱̶㐡Ჱಸ仃ٵᄳ≮䔈⮱≮᲌ܳ
            3   䛺⅛̻֣⅛ࡃጒ㞧                                       㼐᜽̷̸͑͗ܳ≮᲌喑♣ऻ䔆͑͗ܳ≮᲌ںϻጓठ
                                                               ͑͗᫦ा䛺᫝㐀व喑ᰭ㏵ܳ㷯ͧ 8 ͗ᓛ≮᲌喑Ꭳᒏ
                 ќ⅕ധ㟠ധࡃव➖̻χⶊ䚥䧍ౕ䚥ᕔϸ䉕͚ࣺ                          ᜽ 7 ͗э䉕⩹䲏ȡ⩞ڣᲱᐧ⮱ࣺᏁகౕᄦ⩟㠜㘧⮱
            Ꮑ⩌᜽䛺⅛⯽⮱ࣺᏁ⼝ͧ䛺⅛ࡃࣺᏁ喑㔹ࣺᏁ⩌᜽                             䛺⅛ࡃࣺᏁВࣷ䮼ऻ̻㖁ⶩ䚥䶾䗐䚴䚜喍B 2 pin 2 喎䔈
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