Page 42 - 《精细化工》2023年第4期

す 40 ࢤす 4 ᱌ ㇫ ㏳ ࡃ ጒ Vol.40, No.4
20 23 Ꭱ 4 ᰵ FINE CHEMICALS Apr. 2023

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ᓛ䕇䖀ࣺᏁக͚㇫㏳ࡃ႓৮व᜽࢞䮖ጒ㞧ⵁ⾣䔈ᆂ

ᑍუᏤ 1,2,3 喑ᑍᰵ᜽ 1,2,3* 喑䊢㐔ڕ 1,2,3

喍1. ⇠ࡄጒ͇๔႓ ࡃጒ႓䮏喑๖≒ 300131喠2. ⇠ࡄⰮ㐬㞟ࡃጒ̻倅᩵㞯㘪䛺◦჋侹ბ喑๖≒ 300131喠
3. ๖≒ጯ᱙䉕Ⴖڕࡃጒឭᱜ䛺◦჋侹ბ喑๖≒ 300131喎

ᦅ㺮喟࢑ࡃȠ⅔ࡃȠ䛺⅛ࡃȠⶊࡃВࣷיࡃߍ⅏᭜㇫㏳ࡃጒ⩌ϔ͚⮱䛺㺮ࣺᏁ喑䕇፥В䬡⁴᫦ᐼౕ䜉ᐼࣺᏁக
͚䔈㵹喑ႅౕႶڕ䮽ᗐ喑Ꭳࣺ́Ꮑ᩵⢴ѻȡᓛ䕇䖀ࣺᏁகឭᱜ⮱ࣾᆂͧ㼐̷۠䔝䬛䷅᣽ӈγᰶ᩵䕁ᒱ喑఍ₑ喑
ࣾᆂധλᓛ䕇䖀ࣺᏁக⮱Ⴖڕ倅᩵व᜽ጒ㞧᜽ͧᒀݺ㇫㏳ࡃጒ䶳ഌ⮱ⵁ⾣☚◦͸̭ȡ䄒᪴㐩䔝γ䓾ᎡᲒᓛ䕇䖀
ࣺᏁக͚⊶ࣷ㇫㏳ࡃጒϔ৮व᜽࢞䮖ጒ㞧⮱ⵁ⾣䔈ᆂ喑Ꭳᠴܧγᓛ䕇䖀ࣺᏁகႅౕ⮱̺䋠হϷऻⵁ⾣⮱᫦ाȡ
ڠ䩛䃺喟ᓛ䕇䖀ࣺᏁக喠࢑ࡃࣺᏁ喠⅔ࡃࣺᏁ喠䛺⅛ࡃࣺᏁ喠ⶊࡃࣺᏁ喠יࡃߍ⅏
͚ఫܳㆨत喟TQ06 ᪴⡛ᴴ䃳⴮喟A ᪴」㑃त喟1003-5214 (2023) 04-0728-13

Research progresses on hazardous processes for fine

chemical synthesis in microchannel reactors

ZHANG Jiakang 1,2,3 , ZHANG Yuecheng 1,2,3* , ZHAO Jiquan 1,2,3

喍1. School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300131, China; 2. Hebei
Provincial Key Laboratory of Green Chemical Technology and High Efficient Energy Saving, Tianjin 300131, China; 3.
Tianjin Key Laboratory of Chemical Process Safety, Tianjin 300131, China喎

Abstract: Halogenation, oxidation, diazotization, nitration and catalytic hydrogenation, which are important
reactions in synthesis of fine chemicals, are generally carried out in batch reactors with low efficiency and
potential safety hazards. The development of microchannel reactor technology provides an effective
platform to solve the above problems. Therefore, safe and efficient synthetic processes in microchannel
reactors become research focus in production of fine chemicals. Herein, the research progresses in the
synthesis of fine chemicals involving hazardous processes in microchannel reactors in recent years were
summarized, while the shortcomings and future research directions of microchannel reactor were also
discussed.
Key words: microchannel reactor; halogenation; oxidation; diazotization; nitration; catalytic hydrogenation

࢑ࡃࣺᏁȠ⅔ࡃࣺᏁȠ䛺⅛ࡃࣺᏁȠⶊࡃࣺᏁ 䮖ࡃጒጒ㞧ȡᅪノϧЙౕ䪬᱌⮱⩌ϔ჋䌢͚ጟᣏ㉏
Вࣷיࡃߍ⅏ࣺᏁౕ㢜➖Ƞۉ㢜Ƞᴀ᫆Вࣷऱㆨ㇫ ܧ㑀ᚏ䔈᫆Ƞ䭺ѻࣺᏁ➖⊀ᏓȠѻ⍖ࣺᏁВࣷ͒ᵩ
㏳ࡃጒϔ৮⮱व᜽̷ڤᰶᎬ∈⮱Ꮑ⩕ȡ♣㔹喑䔆ψ 䯁⻨ぶႶڕ⩌ϔᣗ᫪喑ѳऱㆨ⩌ϔθᩲϺᬣᰶࣾ⩌ȡ
ࣺᏁ็⊶ࣷᩫ☚Ƞ✳◥ᕔ͚䬡ҀȠ㙽㮭ᕔ䄂ݯȠᰶ ఍㔹喑䔘ܴ䰭㺮ᩦ䔈ᝃ䲖᫝⣝ႅ⩌ϔ䃫ิ̻ጒ㞧ȡ
⃿ᝃ≨ᕔ⅁ҀȠᭀ⛰হ㜗⛰ぶ䬛䷅喑ᰶᬣ䔅䰭㺮倅 䓾ᎡᲒᓄ⯷λ⻾႓ឭᱜ⮱䔈ₒ喑ᓛ䕇䖀ࣺᏁக
⍖ᝃ倅ࢸぶ͒㠈⮱ጒ㞧᲎Уȡэ㐌̷喑䔆ψࣺᏁ็ ឭᱜᓄݝᔘ䕌ࣾᆂȡ᝭䅀ᓛ䕇䖀ࣺᏁகࣵ⼝ᓛࣺᏁ
ౕ䜉ᐼࣺᏁக͚В䬡⁴⮱᫦ᐼ䔈㵹喑఍ₑ喑ႅౕф க喑᭜̭⻺ౕ℈㏳ノ䕇䖀͚჋᫪ࡃ႓ࣺᏁ⮱㷲㒛喑
็⮱⣜ධহႶڕ䮽ᗐ喑㷘పუႶڕ⯾ノᕨᅭჇͧ࢞ ℈㏳ノ⮱ڲᒱ䕇፥ౕ℘ㆠВ̸喑ᰡڤҀౝ䄡喑ౕ

ᩣ⽬ᬒ᱌喟2022-09-03; Ⴧ⩕ᬒ᱌喟2022-10-31; DOI: 10.13550/j.jxhg.20220824
ധ䛾䶦Ⱋ喟⇠ࡄⰮ⩌➖ࡨ㢜㖁वധ䛾䛺◦䶦Ⱋ喍B2022202064喎喠͚๛ᑂᄩౝ᫦⻾ឭࣾᆂ䉱䛾䶦Ⱋ喍206Z4001GȠ216Z1401G喎
҉㔲キϸ喟ᑍუᏤ喍1998ÿ喎喑⩤喑ⶂธ⩌喑E-mail喟jiakangzhang@163.comȡ㖁㈨ϧ喟ᑍᰵ᜽喍1978ÿ喎喑⩤喑᪆ᢵ喑E-mail喟
yczhang@hebut.edu.cnȡ